Method for synthesizing heat-sensitive and biodegradable hydrogel

A technology of biodegradation and synthesis method, applied in the field of polymer hydrogel synthesis, can solve problems such as high molar mass and inability to achieve biodegradation, and achieve the effects of simple operation, safe and reliable synthesis method, and mild reaction conditions

Inactive Publication Date: 2015-04-22
杨俊
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Vernon et al. used PNIPAAM, hydroxyethyl methacrylate (HEMA), acryloyl chloride, and pentaerythritol tetra-3-mercaptopropionate for physical and chemical crosslinking to prepare hydrogels, however, the hydrogels contained Very high molar mass (160kDa), not biodegradable

Method used

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  • Method for synthesizing heat-sensitive and biodegradable hydrogel

Examples

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example 1

[0036] Example 1: The following steps were taken to synthesize a heat-sensitive, biodegradable hydrogel:

[0037] Weigh HEMA and L-lactide with a weight molar ratio of 2:1, and react at 110° C. to obtain HEMA-lactic acid under the catalysis of SnOct2;

[0038] At room temperature, HEMA-lactic acid was reacted with an equimolar amount of N,N'-carbonyldiimidazole (CDI) in tetrahydrofuran (THF) for 17 hours to obtain HEMA-lactateCI;

[0039] HEMA-lactateCI and dextran (molecular weight about 15kDa) were fed at a feed ratio of 1:10, catalyzed by 4-(N,N-dimethylamino)pyridine (DMAP), in dimethyl sulfoxide (DMSO ) solution at room temperature for 4 days to obtain DEXlactateHEMA macromolecule;

[0040] The mass ratio of PNIPAAM and DEXlactateHEMA macromer is 16:1, dissolved in 50% water-1% bovine serum albumin (BSA) (weight percent, pH 2), and the precursor solution is filled in a glass cover with a In the polytetrafluoroethylene model well;

[0041] The precursor s...

example 2

[0043] Example 2: The following steps were taken to synthesize a heat-sensitive, biodegradable hydrogel:

[0044] Weigh HEMA and L-lactide with a weight molar ratio of 3:1, and react at 110° C. to obtain HEMA-lactic acid under the catalysis of SnOct2;

[0045] At room temperature, HEMA-lactic acid was reacted with an equimolar amount of N,N'-carbonyldiimidazole (CDI) in tetrahydrofuran (THF) for 16 hours to obtain HEMA-lactateCI;

[0046] HEMA-lactateCI and dextran (molecular weight about 15kDa) were catalyzed by 4-(N,N-dimethylamino)pyridine (DMAP) at a molar ratio of 1:6 in dimethyl sulfoxide (DMSO) React in the solution at room temperature for 4 days to obtain DEXlactateHEMA macromolecule;

[0047] The 7:2 mass ratio of PNIPAAM and DEXlactateHEMA macromer was dissolved in 70% water-1% bovine serum albumin (BSA) (weight percent, pH 2), and the precursor solution was filled in a glass cover the Teflon model well;

[0048] The precursor solution was stirred i...

example 3

[0050] Example 3: The following steps were taken to synthesize a heat-sensitive, biodegradable hydrogel:

[0051] Weigh HEMA and L-lactide with a weight molar ratio of 4:1, and react under the catalysis of SnOct2 at 110°C to obtain HEMA-lactic acid;

[0052] At room temperature, HEMA-lactic acid was reacted with an equimolar amount of N,N'-carbonyldiimidazole (CDI) in tetrahydrofuran (THF) for 19 hours to obtain HEMA-lactateCI;

[0053] HEMA-lactateCI was added to dextran (molecular weight about 15kDa) at a molar feed ratio of 1:5, under the catalysis of 4-(N,N-dimethylamino)pyridine (DMAP), in dimethyl sulfoxide ( DMSO) solution at room temperature for 4 days to obtain DEXlactateHEMA macromolecule;

[0054] PNIPAAM and DEXlactateHEMA macromer are dissolved in 25% water-1% bovine serum albumin (BSA) (weight percent, pH 2) at a mass ratio of 2:1, and the precursor solution is filled in a belt Teflon model wells with glass covers;

[0055] The precursor solutio...

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Abstract

The invention discloses a method for synthesizing heat-sensitive and biodegradable hydrogel. The method comprises the following steps: preparing a biodegradable cross-linking agent, namely polymerizing lactic acid dimmer lactide and hydroxyethyl methylacrylate to form an intermediate, introducing glucosan to synthesize the biodegradable cross-linking agent by virtue of a chemical reaction; and preparing the heat-sensitive and biodegradable hydrogel, namely dissolving N-isopropylacrylamide, an initiator and the biodegradable cross-linking agent in bovine serum albumin, adding a photoinitiator, performing light initiated polymerization, thereby obtaining the heat-sensitive and biodegradable hydrogel. The poly-N-isopropylacrylamide gel synthesized by the method is decomposed in a certain time due to the degradable structure of the cross-linking agent, and the decomposition products such as polylactic acid and glucosan can participate in human metabolism.

Description

technical field [0001] The invention relates to a synthesis method of a polymer hydrogel, in particular to a synthesis process of a heat-sensitive, biodegradable drug-loaded hydrogel. The polymer hydrogel can be used in biology, medicine, chemistry, agriculture, and daily life. Applications in supplies and other fields. Background technique [0002] Polymer hydrogel is a three-dimensional network and an interpenetrating network formed by the interconnection of polymer macromolecules and the cross-linking and polymerization of long-chain molecules. The biodegradable polymer of polylactic acid (PLA) has attracted more and more scientists' interest in slow-release drug loading, because the main chain ester bonds of polylactic acid can be hydrolyzed into non-toxic alcohols and carboxylic acids, Surgical removal is not required after the drug is consumed. However, due to the hydrophobic nature of PLA, the rate of drug release from PLA is inconsistent. In order to solve these p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F293/00C08F220/54C08F2/48C08B37/02
Inventor 杨俊崔庆孙方杰段振晓王清华
Owner 杨俊
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