Method for synthesizing heat-sensitive and biodegradable hydrogel

A technology of biodegradation and synthesis method, applied in the field of polymer hydrogel synthesis, can solve problems such as high molar mass and inability to achieve biodegradation, and achieve the effects of simple operation, safe and reliable synthesis method, and mild reaction conditions
CN104530336AInactive Publication Date: 2015-04-22杨俊
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
杨俊
Publication Date
2015-04-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for synthesizing heat-sensitive and biodegradable hydrogel. The method comprises the following steps: preparing a biodegradable cross-linking agent, namely polymerizing lactic acid dimmer lactide and hydroxyethyl methylacrylate to form an intermediate, introducing glucosan to synthesize the biodegradable cross-linking agent by virtue of a chemical reaction; and preparing the heat-sensitive and biodegradable hydrogel, namely dissolving N-isopropylacrylamide, an initiator and the biodegradable cross-linking agent in bovine serum albumin, adding a photoinitiator, performing light initiated polymerization, thereby obtaining the heat-sensitive and biodegradable hydrogel. The poly-N-isopropylacrylamide gel synthesized by the method is decomposed in a certain time due to the degradable structure of the cross-linking agent, and the decomposition products such as polylactic acid and glucosan can participate in human metabolism.
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Description

technical field

[0001] The invention relates to a synthesis method of a polymer hydrogel, in particular to a synthesis process of a heat-sensitive, biodegradable drug-loaded hydrogel. The polymer hydrogel can be used in biology, medicine, chemistry, agriculture, and daily life. Applications in supplies and other fields. Background technique

[0002] Polymer hydrogel is a three-dimensional network and an interpenetrating network formed by the interconnection of polymer macromolecules and the cross-linking and polymerization of long-chain molecules. The biodegradable polymer of polylactic acid (PLA) has attracted more and more scientists' interest in slow-release drug loading, because the main chain ester bonds of polylactic acid can be hydrolyzed into non-toxic alcohols and carboxylic acids, Surgical removal is not required after the drug is consumed. However, due to the hydrophobic nature of PLA, the rate of drug release from PLA is inconsistent. In order to solve these p...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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