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Flurbiprofen hydrogel plaster and composition thereof

A flurbiprofen and water-based gel matrix technology, applied in the field of flurbiprofen hydrogel patch, can solve problems such as late start of research, no safe and effective method found, and achieve low dosage and transdermal and good stability

Inactive Publication Date: 2015-04-29
和心医药科技(上海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although technicians have done a lot of research and efforts to solve these problems, due to the late start of research in this field in our country, there are not many materials available for consultation, so a safe and effective method has not yet been found.

Method used

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  • Flurbiprofen hydrogel plaster and composition thereof
  • Flurbiprofen hydrogel plaster and composition thereof
  • Flurbiprofen hydrogel plaster and composition thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The flurbiprofen hydrogel plaster provided in this embodiment is composed of a backing, a paste and an anti-adhesive film, and the composition of the paste includes:

[0042]

[0043] Dissolve 1.5 g of sodium carboxymethyl cellulose in glycerin and partially purified water to obtain component A.

[0044] Dissolve 1.5g of gelatin in partially purified water, heat to 60°C after swelling is complete, and stir evenly until translucent colloid is obtained to obtain component B.

[0045] Dissolve 5.0 g of sodium polyacrylate partially neutralized (NP800) and 0.06 g of aluminum hydroxide in glycerin, stir and mix evenly to obtain component C.

[0046] Dissolve flurbiprofen in crotamiton and N-methylpyrrolidone in advance to make a flurbiprofen solution, then add 0.1 g of sorbitan sesquioleate, 800.1 g of Tween, and isomyristate Add 2 g of acetone, 0.0015 g of peppermint oil, 0.10 g of 1-menthol, and 1.5 g of PEG400, mix, heat at 40-50°C, and stir evenly to obtain component...

Embodiment 2

[0050] The flurbiprofen hydrogel plaster provided in this embodiment is composed of a backing, a paste and an anti-adhesive film, and the composition of the paste includes:

[0051]

[0052]

[0053] Dissolve 1.5 g of sodium carboxymethyl cellulose and 1.0 g of polyvinyl alcohol in glycerin and partially purified water to obtain component A.

[0054] Dissolve 1.0 g of gelatin in partially purified water, heat to 60°C after swelling is complete, and stir until a translucent colloid is obtained to obtain component B.

[0055] Dissolve 6.0 g of sodium polyacrylate partially neutralized (NP700) and 0.06 g of aluminum hydroxide in glycerin, stir and mix evenly to obtain component C.

[0056] Dissolve flurbiprofen in crotamiton in advance, then add sorbitan sesquioleate 0.1g, Tween 800.1g, isopropyl myristate 2g, and then add 1-menthol 0.10g , PEG400 1.5g, D-sorbitol 15g, capsaicin 0.5g, mixed, heated at 40-50°C, stirred evenly to obtain D component.

[0057] Add 0.02 g of p...

Embodiment 3

[0060] The flurbiprofen hydrogel plaster provided in this embodiment is composed of a backing, a paste and an anti-adhesive film, and the composition of the paste includes:

[0061]

[0062]

[0063] Dissolve 1.0 g of sodium carboxymethylcellulose in glycerin and partially purified water to obtain component A;

[0064] Dissolve 2.0 g of gelatin in partially purified water, heat to 60°C after swelling is complete, and stir until a translucent colloid is obtained to obtain component B.

[0065] Dissolve 8.0 g of sodium polyacrylate partially neutralized (NP600) and 0.08 g of aluminum glycolate in glycerin, stir and mix evenly to obtain component C.

[0066] Add flurbiprofen to 2.0g of PEG400, 0.0015g of peppermint oil, 0.0015g of anise oil, 0.5g of polyoxyethylene hydrogenated castor oil, and 0.08g of 1-menthol to mix, heat at 40-50°C, and stir evenly to obtain D component.

[0067] Add 0.12 g of tartaric acid into purified water to obtain component E.

[0068] Disperse...

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Abstract

The invention provides a flurbiprofen hydrogel plaster and a composition thereof. In the composition, the content of flurbiprofen is 0.1-3wt%, and a hydrogel substrate accounts for the rest. Based on the total weight of the hydrogel substrate, the hydrogel substrate comprises the following components: 0.1-40wt% of a hydrophilic base material, 0.01-2wt% of a crosslinking agent, 0.01-4wt% of a crosslinking regulator, 10-60wt% of a humectant, 0.05-45wt% of a penetration enhancer and 10-85wt% of a solvent. According to the flurbiprofen hydrogel plaster provided by the invention, a small number of medicines are used, and the permeability and stability are good; and the flurbiprofen hydrogel plaster can be applied to various arthralgia diseases such as rheumatic arthritis, gouty arthritis, ankylosing spondylitis, tenosynovitis, muscle pain and lumbago.

Description

technical field [0001] The invention relates to a hydrogel plaster, in particular to a flurbiprofen hydrogel plaster with high water content, good stability and transdermal property. Background technique [0002] Flurbiprofen is a class of aryl propionic acid non-steroidal anti-inflammatory drug (NSAID), with a relative molecular weight of 244.26g / mol, a melting point of 114°C-117°C, pKa=4.2, and an oil-water partition coefficient of 3.86 , the solubility is 11mg / ml, and the biological half-life in vivo is 3-5 hours. Flurbiprofen is a non-selective cyclooxygenase inhibitor. It mainly inhibits the synthesis of prostaglandins by inhibiting the cyclooxygenase in the metabolism of arachidonic acid. It has antipyretic, analgesic and anti-inflammatory effects. It is mainly used for bone and joints Inflammation, frozen shoulder, tendon and tenosynovitis, peritenosynovitis, lateral epicondylitis (tennis elbow), muscle pain, swelling and pain caused by trauma. Animal experiments ha...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/192A61P29/00
Inventor 龙本威汤秀珍龚力平韩建鹏蔡金花
Owner 和心医药科技(上海)有限公司
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