166 results about "Muscles pain" patented technology

Topical compositions having as the active ingredient a lipid, fatty acid ester, natural wax, sterol, or combinations thereof referred to herein as “lipophilic vehicle” or “LV” and methods of use, have been developed for the amelioration or prevention of pain or the sequelae of pain. The composition may be in the form of an ointment, cream, gel, lotion, spray, foam, paste, patch, suspension or dispersion. In the preferred embodiment, the formulation is a gel. The LV may contain a penetration enhancer, most preferably one with membrane disruptive properties. The formulation may be applied to or impregnated into a gauze, wrap, bandage, cotton-tipped stick, adhesive bandage strip, or other support wrap or medical bandage or wound cover. For example, the compositions may be are incorporated onto or into disposables such as hemorrhoid wipes, sponge, mouth guards, dental trays; needles or catheters; adult diapers; gloves, socks or wrist bands, for ease of application. The composition is applied topically to a site at or adjacent to a painful region. The composition is reapplied as necessary. Pain relief is typically obtained within minutes and lasts for periods of variable duration ranging from minutes to several hours and even, in some cases, days. The composition is variably effective to treat visceral, somatic and neuropathic pain both acute and chronic as well as muscle pain and stiffness and joint pain and stiffness.

The present invention provides for novel piperazinylalkylpyrazole derivatives, the preparation method thereof and the selective T-type calcium channel blocking activity thereof. Particularly, it provides a piperazinylalkylpyrazole derivative as represented by the formula set forth below or its pharmaceutically acceptable salts, and its preparation method thereof. The compound of Formula 1 is a novel piperazinylalkylpyrazole derivative, which particulary has T-type Ca2+ channel blocking effect and thus can be useful as a therapeutic agent for nerve and muscle pain.

The present invention relates generally to treatment of muscle pain and / or fatigue and to methods for treatment of side effects of statin therapy. In particular, the invention relates to the use of certain substituted benzoquinones, e.g. Coenzymes Q, particularly Coenzyme Q10 (Q10), in therapy. The invention also relates to the use of Q10 in combinative therapy with other agents such as uridine, its biological precursors or salts, esters, tautomers or analogues thereof ("uridine related compounds"). The invention is also directed to compositions, uses and combination packs or kits related to the treatment methods. In a preferred aspect the invention relates to a method of treatment of one or more side effects of statin therapy comprising administering to a subject in need of such treatment an effective amount of uridine, one of its biological precursors or a salt, ester, tautomer or analogue thereof either simultaneously, sequentially or separately to administration of an effective amount of at least one compound of Formula (I).

A composition for suppressing appetite and cravings for substances such as nicotine, coffee, sweets or chocolate while improving energy and enhancing mood comprises theobromine or a salt thereof at an effective amount of from about 250 to 4000 mg. Using such relatively high proportions of theobromine, without added caffeine or ephedrine provides an effective method for promoting weight control or to halt substance cravings without the side effects associated with such stimulants. The composition also includes Rhodiola rosea extract to offset stress effects from reduced food or substance intake, and to further improve mood, and clarity of thought and ability to handle stress, and to also increase endurance while reducing muscle pain.

The invention relates to a medicament for easing the pain of a human body and a preparation method thereof, in particular to a medicament composition with the functions of promoting blood circulation and removing blood stasis, resisting inflammation and diminishing swelling and easing pain, and a preparation method thereof. The medicament composition comprises the raw materials as follows: 20-100 parts by mass of Chinese teasel root, 20-110 parts by mass of cape jasmine fruit, 10-100 parts by mass of Baikal skullcap root and 20-100 parts by mass of angelica root. The preparation method of the medicament composition comprises the following steps of: extracting the raw materials of the medicament composition with water or an ethanol solution, filtering, and collecting the filtrate to obtain the medicament composition, wherein the percent of the ethanol in the ethanol solution by volume is more than 0 and less than or equal to 85%, and the mass ratio of the raw materials to the water or the ethanol solution is 1: 5-8. Clinical experiments show that the medicament composition has good curative effect for easing the neck / shoulder pain, the lumbocrural pain, the joint pain and the muscle pain caused by the rheumatism, the osteoproliferation, tumble and sprain, and the like.

The invention relates to bone-setting plaster prepared by Chinese medicinal herbs, and a preparation method thereof. The bone-setting plaster is prepared by heating and cooking thirty-five Chinese medicinal herbs of erberry, clematis chinensis, typhonium giganteum, ledebouriella seseloides, original excrementum bombycis, and the like. The bone-setting plaster has the effects of blood stasis breakage and pain relief, detumescence, inflammation diminishing, bone reunion and channel dredging, no toxicity and side-effects, and the like, can eliminate the patient pain in the process of setting bones and shorten the recovery period. The bone-setting plaster is used for treating bone and joint organic diseases of diversified properties such as arthritis, scapulohumeral periarthritis, cervical spondylosis, hyperosteogeny, spur, and the like, of various properties, treating traumatic skin, skeleton, and vein pathological changes such as various injuries from falls, fractures, muscular constricture of veins, treating pathological changes from muscular strain such as back pains, muscle pains at neck and shoulder and the like, and is remarkably effective in treatment.

A pharmaceutical composition comprising: (a) meloxicam or a pharmaceutically acceptable salt thereof; and (b) one or more additional pharmaceutically active compounds selected from antacids, sedatives, and central nervous system stimulants, and the use of such composition of an inflammatory disease, symptoms of an inflammatory disease, including various symptoms thereof, and / or headache, toothache, ache after tooth extraction, sore throat, otalgia, arthralgia, neuralgia, lumbago, myalgia, muscle stiffness of shoulder, pain of contusion, pain of fracture, pain of sprain, menstrual pain, traumatic pain, chill, exothermic reaction and / or cold and various symptoms of cold such as sore throat, chill, pyrexia, headache, arthralgia and muscle pain.

The present invention provides pharmaceutically acceptable salts having local anesthetic and anti-inflammatory activities. The preferred pharmaceutically acceptable salt is a diclofenac salt of lidocaine. Diclofenac is a non-steroidal anti-inflammatory drug (“NSAID”). Lidocaine is a local anesthetic. Other NSAID (except the salicylic acid derivatives of NSAID) can be used to replace diclofenac and / or other local anesthetics can be used to replace lidocaine. The pharmaceutically acceptable salts are crystalline compounds, which are distinctively different from either the NSAID alone or the local anesthetic alone, as indicated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), High Performance Liquid Chromatography (HPLC) and Fourier-Transformed Infrared Spectroscopy (FTIR) analyses. These pharmaceutically acceptable salts are suitable for use in topical treatment or parenteral injection to treat patients with localized pain, including muscle pain, joint pain, pain associated with herpes infection, and wound pain (such as surgical wound, burn wound etc.).

A device and method for the application of pressure to a location where muscle pain exists, including at a trigger point. The device and method provide gradual, uniform and systematic progression of pressure and release. The device and method enable the application of pressure in a manner that allows a patient to tolerate the pressure without tensing the relevant muscles and / or causing the locus of pain to become hyperirritable and painful. The device and method also enable the gradual selectable increase in that applied pressure while still preventing the tense response from the patient so that the optimal or desired amount of focused pressure is tolerated. The device enables progressive deep tissue massage in systematic and progressive steps that enhances the treatment of myofascial trigger points in skeletal muscles and other forms of muscle pain. The device includes a plurality of terminal configurations that differ in hardness and / or dimensions.

The invention provides a flurbiprofen hydrogel plaster and a composition thereof. In the composition, the content of flurbiprofen is 0.1-3wt%, and a hydrogel substrate accounts for the rest. Based on the total weight of the hydrogel substrate, the hydrogel substrate comprises the following components: 0.1-40wt% of a hydrophilic base material, 0.01-2wt% of a crosslinking agent, 0.01-4wt% of a crosslinking regulator, 10-60wt% of a humectant, 0.05-45wt% of a penetration enhancer and 10-85wt% of a solvent. According to the flurbiprofen hydrogel plaster provided by the invention, a small number of medicines are used, and the permeability and stability are good; and the flurbiprofen hydrogel plaster can be applied to various arthralgia diseases such as rheumatic arthritis, gouty arthritis, ankylosing spondylitis, tenosynovitis, muscle pain and lumbago.

Topical compositions having as the active ingredient a lipid, fatty acid ester, natural wax, sterol, or combinations thereof referred to herein as “lipophilic vehicle” or “LV” and methods of use, have been developed for the amelioration or prevention of pain or the sequelae of pain. The composition may be in the form of an ointment, cream, gel, lotion, spray, foam, paste, patch, suspension or dispersion. In the preferred embodiment, the formulation is a gel. The LV may contain a penetration enhancer, most preferably one with membrane disruptive properties. The formulation may be applied to or impregnated into a gauze, wrap, bandage, cotton-tipped stick, adhesive bandage strip, or other support wrap or medical bandage or wound cover. For example, the compositions may be are incorporated onto or into disposables such as hemorrhoid wipes, sponge, mouth guards, dental trays; needles or catheters; adult diapers; gloves, socks or wrist bands, for ease of application. The composition is applied topically to a site at or adjacent to a painful region. The composition is reapplied as necessary. Pain relief is typically obtained within minutes and lasts for periods of variable duration ranging from minutes to several hours and even, in some cases, days. The composition is variably effective to treat visceral, somatic and neuropathic pain both acute and chronic as well as muscle pain and stiffness and joint pain and stiffness.

Handheld flashlight type vibratory therapeutic treatment invention, devices, and methods that can house a small piezoelectric crystal adjacent to a bulb in the emitting chamber portion of a flashlight housing, where the crystal is located next to or between light source, or off-axis to the light emitting beam of the flashlight. The crystal can generate a fixed output of approximately 7 to approximately 8 Hertz while the flashlight body is positioned up to approximately 18 inches over the body part being treated with a light beam from the bulb being aimed at the area to be treated. Treatment effectiveness can occur within approximately 2 minutes of being treated. The flashlight invention can be used for treating a variety of ailments such as inflammations, nerve problems, joint pain, muscle pain, as well as gall bladder type problems.

The invention belongs to the technical field of medicines, and particularly relates to a hot compress salt and a preparation method thereof. The hot compress salt is composed of the following ingredients, by weight: 83.5 to 92.5% of granulated salt, 4 to 8 % of Sichuan lovage rhizomes, 2 to 4% of licorice, 1 to 3% of safflower, and 0.5 to 1.5% of Chinese angelica roots. The hot compress salt provided by the invention can diminish inflammation, relieve pain, relax tendons, stimulate blood circulation, alleviate muscle pain, clear blood, and eliminate blood stasis. And the hot compress salt is especially effective in adjuvant therapy of osteoarthritis.

The invention relates to the technical field of medical plastic surgery, in particular to the technical field of facial filling and anti-wrinkle, in particular, it is an injection filling cosmetic modification anti-aging, skin beautification and facial rejuvenation material. The preparation formula of the present invention includes hyaluronic acid, collagen, vitamin E and PLGA. The preparation method comprises: 1) preparing high-viscosity gel; 2) preparing PLGA nano-microspheres; 3) fully mixing high-viscosity gel and PLGA nano-microspheres; 4) sterilizing and filling. Compared with the prior art, the present invention has the beneficial effect that: the combined use of collagen and hyaluronic acid reduces skin erythema, swelling, hardening or itching, muscle pain, urticaria or Other symptoms such as rash. It reduces the probability of severe complications such as peripheral blood circulation embolism, skin necrosis, retinal artery embolism, and cardiocerebral artery embolism that may be caused by simple hyaluronic acid injection, and the safety of product use is improved.

The present invention relates to a shoe sole for triple-time stepping that includes: a front portion having a front end gently inclined upward, and a bottom portion in even contact with the ground; a rear portion having a second cutout inclined upward at an angle of about 15 to 17° from a rear end of the front portion, and a first cutout inclined upward at an angle of about 15 to 25° from a rear end of the second cutout; a first recess formed upward in a predetermined depth on a boundary portion between the front portion and the second cutout; and a second recess formed upward in a predetermined depth on a boundary portion between the second cutout and the first cutout. The improved shoe sole enables a tri-time stepping on walking to remarkably mitigate a fatigue with a massage effect produced from a proper stimulation of the flow of energy to prevent flat-foot walks and promote metabolism and blood circulation, and disperses the impact force caused by the weight to prevent diseases such as arthritis, back pain, muscle pain, or the like.

Topical compositions having as the active ingredient a hydrophilic material, such as a polyalkylene oxide homopolymer or copolymer, and methods of use, have been developed for the amelioration or prevention of pain or the sequelae of pain. The composition may be in the form of a cream, gel, lotion, spray, foam, paste, patch, suspension or dispersion. In the preferred embodiment, the formulation is a gel. The composition may contain a penetration enhancer, most preferably one with membrane disruptive properties. In one embodiment, the compositions are incorporated onto or into disposables such as hemorrhoid wipes, gauze, sponge, bandages, and wraps; mouth guards, dental trays; needles or catheters; adult diapers; gloves, socks or wrist bands, for ease of application. The composition is applied topically to a site at or adjacent to a painful region. The composition is reapplied as necessary. Pain relief is typically obtained within minutes and lasts for periods of variable duration ranging from minutes to several hours and even, in some cases, days. The composition is variably effective to treat visceral, somatic and neuropathic pain both acute and chronic as well as muscle pain and stiffness and joint pain and stiffness.

The invention discloses damp-clearing pain-relieving liquor and an acupoint application treatment method. A proper amount of 45 to 55 percent alcohol is added into a medicament prepared from the Chinese medicaments comprising white mustard seed, dahurian angelica root, ephedra, manchurian wildginger, safflower, camphor, hot pepper and the like in part by weight to form the liquor. The liquor can be applied on the acupoints of the joints and muscle pain parts so as to clear damp, warm and relax veins and relieve pain. The treatment effect is obvious, particularly for treating the cold-dampness syndromes, and the cure rate reaches 96.3 percent.

The invention relates to traditional Chinese medicine decoction for treating rheumatoid arthritis. The traditional Chinese medicine decoction is prepared from the following bulk drugs: 15g of cassia twig, 30g of radix paeoniae rubra, 30g of radix paeoniae alba, 12g of rhizoma anemarrhenae, 15g of radix rehmanniae, 9g of radix aconite, 6g of kusnezoff monkshood, 12g of radix aconiti carmichaeli, 30g of tuckahoe, 12g of dried ginger, 30g of honeysuckle, 30g of forsythia, 30g of honeysuckle stem, 30g of orientvine, 9g of ephedra, 15g of atractylodes, 15g of rhizoma atractylodis, 30g of seed of Jobs tears, 30g of radix astragali, 12g of angelica, 12g of peach kernel, 12g of safflower, 2 centipedes, 15g of tripterygium wilfordii, 30g of radix isatidis, 30g of sargentgloryvine stem, 12g o f alisma, 6g of licorice root, 10g of radices sileris, 15g of rhizoma cibotii, 15g of ginger, and 15g of notopterygium. The traditional Chinese medicine decoction provided by the invention has the effects of relieving joint and muscle pain, and the like, and has significant curative effect in the treatment of the rheumatoid arthritis and the like, with the effective rate of 96.6%, and without toxic or side effect.

An electromyographic (EMG) device for the diagnosis and treatment of muscle injuries associated with pain, stiffness, and movement disorders which is configured for diagnosing chronic and recurrent muscle pain and which includes two active EMG electrodes and an EMG reference electrode which when attached to the subject patient can measure and display electromyographic signals. The device includes an integrated stimulator that can be used for treating chronic and recurrent muscle pain, by evoking stimulation, or E-stim, location. The device includes a visual display system for displaying raw and processed EMG and is configured to provide for audio feedback based on the raw EMG.

The invention relates to uric acid-lowering marine fish oligopeptide and a preparation method thereof. According to the preparation method, marine fish is taken as a raw material, the fish meat of themarine fish is treated by using methods such as a steam explosion treatment method, a protease enzymolysis method and a microbial fermentation method, and desalting treatment is carried out by combining ultrasonic waves with a membrane separation technique, so that the uric acid-lowering marine fish oligopeptide product can be finally obtained; the obtained acid-lowering marine fish oligopeptideproduct is stable in properties, high in contents of active components and low in salt content, has effects of reducing uric acid, improving endurance, relieving muscle pain and the like, can be matched with euglena for use, is also used as a food additive, a raw material for health care products and the like, has a high economic value, and is suitable for large-scale industrialized production.

An air-bed for a vehicle has a front seat on which an air-bed filled with air can be formed after a back of the front seat is reclined rearward, thereby providing a comfortable, easy rest space during a long distance tour or auto camping. An air-bed for a vehicle can be used in the vehicle during a long distance tour or auto camping. The air-bed for the vehicle is designed to provide a full level plane and to thereby provide comfortable rest without muscle pain that may be caused by protruded portions formed by unevenness of front and rear seats.

Non-aqueous patches comprising lidocaine, which is not dissolved and is present in a crystalline state, have poor permeability to the skin. Therefore, non-aqueous patches have a high concentration of lidocaine. It is pointed out that lidocaine has an adverse effect on the heart. Prolonged use of a high concentration of lidocaine causes side effects, such as shock, rubor, and irritating sensation. External preparations comprising more than 5 mass % of lidocaine are designated as powerful drugs, and cannot be used as household (nonprescription) medicine. Provided is a non-aqueous patch that is effective to relieve muscle pain, the non-aqueous patch comprising lidocaine and / or its reactant, and a dissolving agent composed of an organic acid and a polyalcohol, which are contained in a base.

The invention provides a traditional Chinese medicine composition for treating arthralgia caused by wind-damp-heat pathogens. The composition is prepared by the following active pharmaceutical ingredients of, by weight, 5-18 parts of processed semen strychni, 9-15 parts of gentiana macrophylla, 9-15 parts of radix stephaniae tetrandrae, 9-15 parts of processed olibanum, 9-15 parts of processed myrrh, 9-15 of lumbricus, 9-15 parts of wall gecko, 9-15 parts of gastrodia elata, 9-15 parts of glabrous greenbrier rhizome and 9-15 parts of cortex phellodendri. The composition has the functions of clearing heat and detoxicating, dispelling wind and eliminating dampness, promoting blood circulation to remove meridian obstruction, bringing down fever and reducing swelling, suppressing spasm and relieving pain, invigorating stomach to help digestion, and the like, and has significant curative effects for pyretic arthralgia, limbs and muscle pain which belong to pyretic arthralgia categories such as rheumatoid arthritis, rheumatic arthritis, arthrolithiasis, hyperostosis, lumbar bone hyperplasia, lumbar disc herniation, sciatica and the like and are mainly characterized by local inflamed hot pain; for joint pain symptoms of people having thermal type constitutions such as people with damp-heat constitutions and internal heat constitutions, patients with hypertension and diabetes, or the crowds suffering from rheumatoid arthritis diseases and easy to suffer from excessive internal heat when taking drugs of hot nature; or for joint, muscle, and tendon pain symptoms of the crowds who may suffer from stomach indigestion at the same time.

The present invention relates to delivery, including transdermal delivery, of a therapeutically effective amount of a compound useful for modulating gap junction formation and function, including an oligonucleotide for reducing gap junction formation and function, and methods and compositions for treating a subject suffering from pain associated with a disease, disorder or condition and associated with pain, including but not limited to muscle pain, ligament pain, tendon pain, joint pain and post-operative pain.

Compositions and methods for alleviating the symptoms associated with muscle pain in general or muscle wasting are provided. The compositions are based on use of androgens, either alone or in combination with other hormones, including growth hormone.

Portable therapeutic treatment devices and methods with a triangular arrangement of crystals in an induction coil with an external wrapped coil for sensing effected area body part emissions. A biosensor / bioscanner sensor can be used as an indicator to find an effected body part needing treatment and determine when treatment has been effective. The device can be passed over a body until a RED LED light indicates an effected part needing treatment. Treatment can occur with approximately 8 Hz emissions, and the sensor will indicate when the effected area has reached a treated state of approximately 8 Hz by lighting a GREEN LED light. Treatment can occur within approximately 2 minutes. A variety of ailments can be treated such as but not limited to inflammations, nerve problems, joint-pain, muscle-pain, gall bladder problems, and the like.

The present invention provides with local narcosis and antiphlogosis activity, and the optimal salt is diclofenac salt of lidocaine. Diclofenac acid is one kind of non-steroid anti-inflammatory drug (NSAID), and lidocaine is one kind of local anaesthetic, with diclofenac acid and / or lidocaine being replaceable with other NSAID and / or other local anaesthetic separately. The medicinal salt is crysalline compound dissimilar to NSAID and lidocaine obviously, as DSC, TGA, HPLC and FTIR show. The medicinal salt is especially suitable for local treatment and injection outside gastrointestinal tract to treat local pain including muscle pain, joint pain, pain related to herpes, wound pain, etc.

A method of topical application of a creatine composition for treating and / or inhibiting recurrence of muscle cramps / spasms as well as muscle pain and / or stiffness associated therewith.

Topical compositions having as the active ingredient a lipid, fatty acid ester, natural wax, sterol, or combinations thereof referred to herein as “lipophilic vehicle” or “LV” and methods of use, have been developed for the amelioration or prevention of pain or the sequelae of pain. The composition may be in the form of an ointment, cream, gel, lotion, spray, foam, paste, patch, suspension or dispersion. In the preferred embodiment, the formulation is a gel. The LV may contain a penetration enhancer, most preferably one with membrane disruptive properties. The formulation may be applied to or impregnated into a gauze, wrap, bandage, cotton-tipped stick, adhesive bandage strip, or other support wrap or medical bandage or wound cover. For example, the compositions may be are incorporated onto or into disposables such as hemorrhoid wipes, sponge, mouth guards, dental trays; needles or catheters; adult diapers; gloves, socks or wrist bands, for ease of application. The composition is applied topically to a site at or adjacent to a painful region. The composition is reapplied as necessary. Pain relief is typically obtained within minutes and lasts for periods of variable duration ranging from minutes to several hours and even, in some cases, days. The composition is variably effective to treat visceral, somatic and neuropathic pain both acute and chronic as well as muscle pain and stiffness and joint pain and stiffness.