797results about How to "High pressure" patented technology

A blower for providing a supply of air at positive pressure in the range of approximately 2 cm H2O to 30 cm H2O includes a motor, at least one impeller, and a stationary component. The stationary component includes an inlet and an outlet. The motor, the impeller, the inlet and outlet are co-axial.

A pressure isolation mechanism for use in a medical procedure includes a lumen, an isolation port in fluid connection with the lumen, and a valve having a first state and a second state. The first state occurs when the lumen and the isolation port are connected. The second state occurs when the lumen and the isolation port are disconnected. The lumen remains open for flow of fluid therethrough in the first state and in the second state. The valve is preferably spring-biased in the first state and is switchable to the second state when fluid pressure in the lumen reaches a predetermined pressure level. Alternately, an actuator can control the state of the valve. A pressure transducer can be in fluid connection with the isolation port of the pressure isolation mechanism. A fluid delivery system includes a syringe and a pressure isolation mechanism as described above.

Systems for treating a bone, e.g. a vertebral body, having an interior volume occupied, at least in part, by cancellous bone provide a first tool, a second tool, and a third tool. The first tool establishes a percutaneous access path to bone. The second tool is sized and configured to be introduced through the percutaneous access path to form a void that occupies less than the interior volume. The third tool places within the void through the percutaneous access path a volume of filling material. Related methods for treating a bone, e.g. a vertebral body, having an interior volume occupied, at least in part, by cancellous bone provide establishing a percutaneous access path to bone. A tool is introduced through the percutaneous access path and manipulated to form a void that occupies less than the interior volume. A volume of filling material is then placed within the void through the percutaneous access path.

The present invention describes methods and processes for the production of proteins, particularly glycoproteins, by animal cell or mammalian cell culture, illustratively, but not limited to, fed-batch cell cultures. The methods comprise feeding the cells with D-galactose, preferably with feed medium containing D-galactose, preferably daily, to sustain a sialylation effective level of D-galactose in the culture for its duration, thus increasing sialylation of the produced proteins. The methods can also comprise at least two temperature shifts performed during the culturing period, in which the temperature is lower at the end of the culturing period than at the time of initial cell culture. The cell culture processes of the invention involving two or more temperature shifts sustain a high cell viability, and can allow for an extended protein production phase. The methods can also comprise the delayed addition of polyanionic compound at a time after innoculation. Supplementation of the cultures with D-galactose, preferably in a feed medium, to sustain galactose at sialylation effective levels in the cultures until the end of a culture run reverses a decline in sialylation that accompanies culture scale up, and is advantageous for large scale culturing processes.

An absolute pressure sensor includes a sense die with a reference chamber on a top side thereof. The reference chamber comprises a precisely fabricated beam that limits the travel of a diaphragm. The beam can be positioned in a cap or cover member of the sense die, thereby allowing the sense die diaphragm to move freely for a particular distance. Over this distance, the sense die will have one sensitivity. When the sense die is pressurized to a certain point, the diaphragm moves until it contacts the beam member in the cap or cover. When the diaphragm hits the beam, the sensitivity of the sense die changes, thereby allowing a smaller voltage out for the greater pressure in. Such an arrangement permits the sensor to provide a function that accurately measures low pressure and measures a higher pressure without utilizing a linear scale.

Apparatuses for restricting fluid flow through a well conduit comprise a housing having a longitudinal bore and a seat disposed within the bore. The seat has a first position when the apparatus is in the run-in position and a second position when the apparatus is in the set position. The seat comprises an arcuate member comprising a plurality of slits defining a plurality of segment members having a gap there-between. Each of the gaps are variable such that movement of segment members inwardly causes the gaps to be narrowed or closed off completely when a plug element is disposed into the bore and landed on the arcuate member to move the arcuate member from the first position to the second position, causing restriction of fluid flow through the bore and the well conduit.

Apparatuses for restricting fluid flow through a well conduit comprise a housing having a longitudinal bore and a reusable seat disposed within the bore. The seat comprises a slidable element, a fixed element, a plug element support member, a seat inner diameter, and a return member to urge the slidable element toward the run-in position. The plug element support member has a retracted position when the seat is in the run-in position and an extended position when the seat is in the set position. A plug element adapted to be disposed into the bore and landed on the seat to restrict fluid flow through the bore and the well conduit is used to move the plug element support member from the retracted position to the extended position, thereby providing support to the plug element landed on the seat.

Described herein are nasal respiratory devices, in particular, nasal respiratory devices configured to achieve positive end-expiratory pressure (PEEP) in a subject wearing the device. PEEP devices may have a threshold pressure for opening during expiration. In some variations, these devices have a threshold pressure for closing during expiration.

Apparatuses for closing a well conduit comprise a housing having a longitudinal bore and a seat disposed within the bore. A chamber is disposed within the housing and includes a plug element support member, such as ram or piston, operatively associated within the chamber. The plug element support member has a retracted position and an extended position. A passageway is in fluid communication with the bore and the chamber. A plug element such as a ball or drop plug, is adapted to be disposed into the bore and landed on the seat to restrict fluid flow through the bore and the well conduit. Landing the plug element causes and allowing fluid pressure to build causes the plug element support member to move from the retracted position to the extended position to provide support to the plug element landed on the seat.

A support contour of a cushion, such as a wheelchair cushion, defines relief areas at locations adjacent to skin covering the ischial tuberosities, the greater trochanters and the coccyx and sacrum of a person sitting on the support contour. Support areas of the support contour transfer force into the pelvic area adjacent to skin covering tissue masses on opposite lateral sides of the posterior buttocks and beneath the proximal thighs of the person. Greater clearance is also provided in the perineal area. Risks of pressure ulcers from pressure and shear forces on bony prominences is reduced while providing support at the broader areas without bony prominences in such a manner to encourage postural alignment. The risks of skin breakdown perineal are diminished.

A flexible support structure of a seat cushion, such as a wheelchair cushion, has an upper surface with a support contour having relief areas for establishing relatively less pressure on skin adjacent to bony prominences of a user's pelvis and having a support area for establishing relatively more pressure on skin covering a tissue mass spaced from the bony prominences. A slit is formed in the rear corner of the support structure and an insertion member is inserted into the slit to change a position of the support area to thereby adjust the support contour for better support of the pelvic area. A cover encases the support structure to resist outward deformation of the support structure. The cover has an extension portion that expands the cover at the rear corner to increase a dimension of the cover to encase an increase dimension of the corner caused by the insertion of the insertion member.

Coated inflatable fabrics, more particularly airbags to which very low add-on amounts of coating have been applied, are provided which exhibit extremely low air permeability. The inventive inflatable fabrics are primarily for use in automotive restraint cushions that require low permeability characteristics (such as side curtain airbags). Traditionally, heavy, and thus expensive, coatings of compounds such as neoprene, silicones and the like, have been utilized to provide such required low permeability. The inventive fabric utilizes an inexpensive, very thin coating to provide such necessarily low permeability levels. Thus, the inventive coated inflatable airbag comprises a film laminated on at least a portion of the target fabric surface wherein the film possesses a tensile strength of at least 2,000 and an elongation at break of at least 180%. The film provides a low permeability airbag cushion exhibiting a leak-down time of at least 5 seconds as well as a very low packing volume (for more efficient use of storage space within a vehicle) for the target side curtain airbag.