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Coptis chinensis extract solution for preventing and treating dairy cow mastitis and preparation method thereof

A Coptis chinensis extract, a technology for dairy cow mastitis, which is applied in the directions of medical preparations containing active ingredients, pharmaceutical formulations, drug delivery, etc. Reliability and other issues, to achieve the effect of reliable effect, avoiding secondary infection and convenient administration

Inactive Publication Date: 2017-06-06
四川中农致远生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Based on the currently disclosed traditional Chinese medicine composition for the treatment of cow mastitis, the number of medicines is large, individual medicinal materials are scarce, the cost is high, and the curative effect is general, which is not conducive to pharmaceutical companies to carry out drug production, quality control and popularization and application. Due to factors such as the nature of the substance, biological activity, and characteristics of production practice, the direct use of Coptis chinensis extract has defects such as inconvenient medication, unreliable curative effect, and high treatment cost. The present invention prepares the Coptis chinensis extract into a solution and simultaneously uses it in production practice Prevention and treatment of mastitis in dairy cows and veterinary clinics

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Preparation of Coptis chinensis extract: Take Coptis chinensis powder and pass it through a 20-mesh sieve to obtain coarse powder, heat and reflux extract the crude fraction with 8 times the amount of 80% ethanol at 90°C for 2 times, each time for 1.5h, combine the filtrates and concentrate, put Dry in a drying oven to a constant weight state to obtain the Coptidis Rhizome extract;

[0023] Take 15g of Coptidis Rhizoma extract and dissolve in 250ml of 50% ethanol, then add 10ml of eucalyptus oil, 3ml of azone, 90ml of propylene glycol successively, add distilled water to make the volume to 500ml, and mix well to obtain a solution of Coptis chinensis extract. After testing, the properties of this solution are brown, transparent and slightly viscous liquid, and the pH and microbial limit are all qualified.

Embodiment 2

[0025] Preparation of Coptis chinensis extract: Take Coptis chinensis powder and pass it through a 20-mesh sieve to obtain coarse powder, heat and reflux extract the crude fraction with 8 times the amount of 80% ethanol at 90°C for 2 times, each time for 1.5h, combine the filtrates and concentrate, put Dry in a drying oven to a constant weight state to obtain the Coptidis Rhizome extract;

[0026] Take 10g of Coptis chinensis extract and dissolve in 200ml of 50% ethanol, then add 8ml of eucalyptus oil, 2ml of azone, 80ml of propylene glycol successively, add distilled water to make up to 500ml, mix well to get the solution of Coptis chinensis extract. After testing, the properties of this solution are brown, transparent and slightly viscous liquid, and the pH and microbial limit are all qualified.

Embodiment 3

[0028] Preparation of Coptis chinensis extract: Take Coptis chinensis powder and pass it through a 20-mesh sieve to obtain coarse powder, heat and reflux extract the crude fraction with 8 times the amount of 80% ethanol at 90°C for 2 times, each time for 1.5h, combine the filtrates and concentrate, put Dry in a drying oven to a constant weight state to obtain the Coptidis Rhizome extract;

[0029] Take 7.5g of Coptis chinensis extract and dissolve it in 150ml of 50% ethanol, then add 6ml of eucalyptus oil, 1ml of azone, 70ml of propylene glycol, add distilled water to make it 500ml, and mix well to get the solution of Coptis chinensis extract. After testing, the properties of this solution are brown, transparent and slightly viscous liquid, and the pH and microbial limit are all qualified.

[0030] The solution prepared in Example 1 has been studied in the following pharmacodynamics

[0031] 1 method

[0032] 1.1 Antibacterial activity research in vitro

[0033] 1.1.1 Prepa...

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PUM

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Abstract

The invention discloses a rhizoma coptidis extract solution for the prevention and control of mastitis of dairy cattle and a preparation method thereof. The preparation method comprises the following steps: mixing a stabilizing agent, a penetrating agent, a rhizoma coptidis extract and a solvent, stirring so as to fully dissolve the mixture, and filtering to obtaining the rhizoma coptidis extract solution. The preparation method of the rhizoma coptidis extract solution has the advantages of good stability of preparations, high process repeatability, simple process, strong operability, reasonable cost, and the like. The prepared rhizoma coptidis extract solution is brown, transparent and uniform liquid, and can be conveniently applied and sprayed; and production practices and veterinary clinical tests show that the rhizoma coptidis extract solution provided by the invention can be used for preventing and controlling the mastitis of dairy cattle, reducing and eliminating the bacterial quantity in infected cattle milk and removing breast lumps of dairy cattles, so that milk is thickened, and the milk yield is increased.

Description

technical field [0001] The invention relates to a coptis extract solution for preventing and treating cow mastitis and a preparation method thereof, in particular to a coptis extract solution capable of preventing and treating cow mastitis and a preparation method thereof. Background technique [0002] Cow mastitis (Cow Mastitis) is an inflammatory response caused by the invasion of pathogenic microorganisms, mechanical stimulation and chemical and physical damage to the mammary gland tissue of dairy cows. It is manifested as inflammation of breast parenchyma and interstitium, and the number of somatic cells in milk increases. Dairy cow mastitis is a common, multiple and complex comprehensive mammary gland disease in the process of dairy farming, and it is also one of the diseases that cause major economic losses in the dairy industry. As early as 1884, Nocard and Mollerea had successfully isolated the first strain of Streptococcus from milk and successfully replicated it i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/718A61K9/08A61P15/14
Inventor 殷中琼郭文竹贾仁勇赵兴洪彭练慈宋旭李莉陈振振赖昕周讯
Owner 四川中农致远生物科技有限公司