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A kind of preparation method of safflower essence capsule

The technology of safflower essence and safflower yellow pigment is applied in the field of preparation of safflower essence capsules, which can solve the problems of easy failure in production, storage and use, less extraction of safflower effective components, limiting the efficacy of effective components and the like. , to achieve the effect of improving comprehensive utilization, preventing and treating hyperlipidemia, and delaying oxidative deterioration.

Inactive Publication Date: 2017-06-16
QINGHAI UNIV FOR NATITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although there is experimental research on the extraction of safflower essence in the prior art, it is difficult to enter the actual large-scale production and sales
First of all, because the extraction efficiency of safflower is low, and the extraction amount of effective components of safflower per unit mass is small; it is difficult to extract large-scale and high-purity active components of safflower
Secondly, the applicant found in actual research that safflower yellow, unsaturated fatty acids and 5-hydroxytryptamine are easy to oxidize and deteriorate in the natural environment, and the efficacy of the medicine decreases significantly with the prolongation of storage time after being prepared
The above technical problems lead to its easy failure during production, storage and use, thus limiting the efficacy of these active ingredients

Method used

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  • A kind of preparation method of safflower essence capsule

Examples

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Effect test

Embodiment 1

[0027] Embodiments 1 to 3 are specific implementations of a method for preparing safflower essence capsules of the present invention, wherein embodiment 1 is the best embodiment.

[0028] Example 1

[0029] 1) Extraction of safflower yellow pigment: soak for 30-40 minutes according to the ratio of dry material of safflower corolla to water mass ratio of 1:20, then use ultrasonic extractor to perform ultrasonic extraction for 3 times, extraction temperature is 60-62°C, extraction time is 43-46 minutes , to obtain the extract by filtration; pass the extract through HPD-826 macroporous adsorption resin at a loading flow rate of 3BV / h, after the adsorption is completed, let the extract stand for 2 hours, and elute with distilled water at a flow rate of 6BV / h until the Molish reaction is Negative; then elute with 50% ethanol solution by volume at a flow rate of 6BV / h, collect the eluate, and concentrate the eluate under reduced pressure at 50°C to a density of 1.08g / cm ３ , vacuum ...

Embodiment 2

[0036] 1) Extraction of safflower yellow pigment: Soak for 40 minutes according to the mass ratio of safflower corolla dry material to water 1:19, then use an ultrasonic extractor to perform ultrasonic extraction twice, extraction temperature is 62°C, extraction time is 43 minutes, and the extract is obtained by filtration; Pass the extract through HPD-826 macroporous adsorption resin at a loading flow rate of 3BV / h. After the adsorption is complete, let the extract stand for 3 hours, and elute with distilled water at a flow rate of 6.5BV / h until the Molish reaction is negative; The percentage concentration of 50% ethanol solution was eluted at a flow rate of 6.5BV / h, the eluate was collected, and the eluate was concentrated under reduced pressure at 50°C to a density of 1g / cm ３ , vacuum drying or freeze-drying at 45°C to obtain solid safflower yellow;

[0037] 2) Embedding of safflower yellow: weigh solid safflower yellow and β-cyclodextrin at a mass ratio of 1:7, and mix β-c...

Embodiment 3

[0043] 1) Extraction of safflower yellow pigment: Soak for 35 minutes according to the ratio of dry material of safflower corolla to water mass ratio of 1:21, then use an ultrasonic extractor to perform ultrasonic extraction for 3 times, the extraction temperature is 61°C, the extraction time is 46 minutes, and the extract is obtained by filtration; Pass the extract through HPD-826 macroporous adsorption resin at a loading flow rate of 3BV / h. After the adsorption is completed, let the extract stand for 2~3h, and elute with distilled water at a flow rate of 6BV / h until the Molish reaction is negative; then use The ethanol solution with a concentration of 50% by volume was eluted at a flow rate of 6BV / h, the eluate was collected, and the eluate was concentrated under reduced pressure at 50°C to a density of 1.04g / cm ３ , vacuum drying or freeze-drying at 45°C to obtain solid safflower yellow;

[0044] 2) Embedding of safflower yellow pigment: Weigh the solid safflower yellow pigm...

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Abstract

The invention discloses a preparation method of a flos carthami essence capsule, and belongs to the technical field of plant extracts. The method comprises the following steps: (1) extracting carthamin yellow; (2) embedding the carthamin yellow; (3) extracting a safflower oil crude product; (4) refining and embedding the safflower oil; (5) extracting 5-hydroxytryptamine; and (6) preparing the capsule. The flos carthami essence capsule prepared by the preparation method of the flos carthami essence capsule disclosed by the invention is relatively high in content of carthamin yellow, unsaturated fatty acid and 5-hydroxytryptamine; according to the preparation method, the oxidation speed of the carthamin yellow, the unsaturated fatty acid and the 5-hydroxytryptamine can be obviously delayed; the medicine activity can be kept for a long period of time; and storage and marketing are facilitated.

Description

technical field [0001] A preparation method of safflower essence capsule belongs to the technical field of plant extracts. Background technique [0002] Safflower is a medicinal and edible plant resource of Compositae, and its effective parts are corolla and seeds. The safflower corolla is rich in safflower yellow, and the seeds are rich in unsaturated fatty acids and 5-hydroxytryptamine. [0003] Safflower yellow pigment is a natural yellow pigment extracted from the corolla of safflower, which is a chalcone compound. It is an edible natural pigment approved and allowed to be used in China. It has been listed in GB2760-1996 and is a national new drug. It has the effects of promoting blood circulation, promoting menstruation, removing blood stasis, relieving pain, lowering cholesterol, and lowering blood pressure. Safflower seed oil, also known as safflower oil, is an oil made from safflower seeds. It has the functions of softening blood vessels, expanding arteries, stab...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K36/286A61K47/69A61P9/00A61P3/06A61P25/20
Inventor 赵素琴保怡林鹏程
Owner QINGHAI UNIV FOR NATITIES
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