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Multivitamin composition and preparation method thereof

A vitamin and composition technology, applied in the field of vitamin composition and its preparation, can solve problems such as different dissolution properties, complex physical and chemical properties, and content reduction

Inactive Publication Date: 2015-05-13
北京藏卫信康医药研发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Existing technologies have shown that vitamin components have complex physical and chemical properties, different solubility properties, are unstable, and are sensitive to light, heat, oxygen, metal ions, acidity, etc., and their storage conditions are often strict, such as folic acid. , Vitamin D is required to be protected from light, sealed, filled with nitrogen, and stored in a cold place; the components of vitamins are also unstable, such as vitamin B 1 , Vitamin B 12 The interaction will reduce the content, vitamin B 12 Can reduce vitamin C content

Method used

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  • Multivitamin composition and preparation method thereof
  • Multivitamin composition and preparation method thereof
  • Multivitamin composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] (1) Take vitamin A palmitate and vitamin D in a dark operating room 3 , vitamin E, vitamin K 1 , added to polysorbate 80, mixed and stirred to dissolve, and an appropriate amount of water for injection was added to obtain a fat-soluble vitamin solution, which was set aside;

[0085] (2) Get folic acid and biotin, add appropriate amount of sodium hydroxide solution to dissolve, set aside;

[0086] (3) Take the remaining vitamins and histidine hydrochloride, add water for injection to dissolve, mix well, add the above-mentioned folic acid and biotin solution, mix well, adjust the pH value to 5.1 with sodium hydroxide and citric acid, and obtain water-soluble vitamins solution, spare;

[0087] (4) Mix the above-mentioned fat-soluble vitamin solution and water-soluble vitamin solution, filter through a filter with a pore size of 0.22 μm, add water for injection to the full amount, carry out sterilizing filtration through two filters with a pore size of 0.22 μm connected i...

Embodiment 2

[0089] Except that the pH value is adjusted to 4.3 and the filling volume is 3.5ml / bottle, it is prepared according to the process in Example 1, and it is ready.

Embodiment 3

[0091] Except for adding mannitol and adjusting the pH value to 5.6 during the preparation of water-soluble vitamins, it is prepared by the same process as in Example 1.

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Abstract

The invention relates to a multivitamin composition and a preparation method thereof, the multivitamin composition contains vitamin A palmitate, vitamin D3, vitamin E, vitamin K1, vitamin C, vitamin B1, riboflavin sodium phosphate, vitamin B6, vitamin B12, folic acid, dexpanthenol, biotin, nicotinamide, histidine and its salts and polysorbate 80, and compared with the prior art, the multivitamin composition has better solution clarity and can better ensure drug safety and convenient clinical use.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a multivitamin composition and a preparation method thereof. Compared with the prior art, the invention has better solution stability and is more convenient for clinical use. technical background [0002] Parenteral nutrition plays an important supporting role in the treatment of diseases, and is widely used in congenital digestive tract malformations, moderate to severe malnutrition, digestive tract diseases (severe diarrhea, necrotizing enterocolitis, early short bowel syndrome, intestinal Obstruction, intestinal fistula, necrotizing pancreatitis), critically ill newborns who cannot eat normally, severe gastrointestinal reactions caused by radiotherapy and chemotherapy, severe infection, major surgery, trauma, burns, etc. Vitamins are a kind of trace organic substances necessary to maintain human life activities. Generally, they cannot be synthesized by th...

Claims

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Application Information

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IPC IPC(8): A61K31/714A61K47/34A61P3/02A61K31/593A61K31/525A61K31/23A61K31/355A61K31/122A61K31/375A61K31/51A61K31/4415A61K31/519A61K31/164A61K31/4188A61K31/455
Inventor 胡军王冬生刘烽张勇
Owner 北京藏卫信康医药研发有限公司
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