Phenolic hydroxyl modified adsorption resin and application thereof

An adsorption resin, phenolic hydroxyl technology, applied in the field of functional polymer adsorption resin, can solve the problems of insufficient separation and purification efficiency and poor selectivity of stilbene glycosides, achieve good separation and purification ability, improve adsorption efficiency and selectivity, The effect of good application prospects

Inactive Publication Date: 2015-05-13
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the technical problems of insufficient separation and purification efficiency and poor selectivity of stilbene glycosides in Radix Polygoni Multiflori with existing macroporous adsorption res

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1: A preparation method of phenolic hydroxyl modified adsorption resin, comprising the steps of:

[0039]The chloromethylated polystyrene-divinylbenzene microspheres are fully washed with deionized water and methanol to remove the residues in the pores of the microspheres, and then the cleaned microspheres are vacuum-dried at 80°C 4 h; weigh 10 g of vacuum-dried chloromethylated polystyrene-divinylbenzene microspheres, swell in 100 mL of nitrobenzene for 12 h, add 3.0 g of phenol for mechanical stirring, and then add 2 g of anhydrous zinc chloride, heated to 95°C and stirred for 4 h, fully dissolved, Friedel-Crafts post-crosslinking reaction (Friedel-Crafts post-crosslinking reaction); filter the solution after post-crosslinking reaction, and use Rinse the washed microspheres with deionized water until the silver nitrate solution is added to the deionized water after washing the microspheres, and no white precipitates are produced to obtain the phenolic hydroxy...

Embodiment 2

[0040] Example 2: A preparation method of phenolic hydroxyl modified adsorption resin, comprising the steps of:

[0041] Thoroughly wash the chloromethylated polystyrene-divinylbenzene microspheres with deionized water and methanol to remove the residues in the pores of the microspheres, and then vacuum-dry the cleaned microspheres at 83°C 4.5 h; Weigh 20 g of vacuum-dried chloromethylated polystyrene-divinylbenzene microspheres, swell in 200 mL of nitrobenzene for 8 h, add 5.0 g of phenol for mechanical stirring, and then add 4 g anhydrous zinc chloride, heated to 90°C for 6 hours, fully dissolved, Friedel-Crafts post-crosslinking reaction (Friedel-Crafts post-crosslinking reaction); filter the solution after post-crosslinking reaction, and deionized water Rinse the microspheres after the washing reaction until the silver nitrate solution is added to the deionized water after washing the microspheres, and no white precipitate is produced, so as to obtain the phenolic hydrox...

Embodiment 3

[0042] Example 3: A preparation method of phenolic hydroxyl modified adsorption resin, comprising the steps of:

[0043] The chloromethylated polystyrene-divinylbenzene microspheres are fully washed with deionized water and methanol to remove the residues in the pores of the microspheres, and then the cleaned microspheres are vacuum-dried at 85°C 5 h; Weigh 30 g of vacuum-dried chloromethylated polystyrene-divinylbenzene microspheres, swell in 300 mL of nitrobenzene for 10 h, add 10.0 g of phenol for mechanical stirring, and then add 6 g of anhydrous zinc chloride, heated to 93°C for 10 h, fully dissolved, Friedel-Crafts post-crosslinking reaction (Friedel-Crafts post-crosslinking reaction); filter the solution after post-crosslinking reaction, and deionized Rinse the microspheres after the washing reaction with water until silver nitrate solution is added to the deionized water after washing the microspheres, and no white precipitate is produced to obtain the phenolic hydro...

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Abstract

The invention provides phenolic hydroxyl modified adsorption resin which is a grafted chloromethylated polyphenylene diene-divinyl benzene microsphere containing a phenolic hydroxyl group, and the content of the phenolic hydroxyl group is 1.50-2.86 mmol/g. The invention also provides application of the phenolic hydroxyl modified adsorption resin to the separation and the purification of stibene glucoside in polygonum multiflorum. According to the phenolic hydroxyl modified adsorption resin, the phenolic hydroxyl group is introduced onto the chloromethylated polyphenylene diene-divinyl benzene microsphere, so that the adsorption efficiency and the selectivity of the phenolic hydroxyl modified adsorption resin for the stibene glucoside in the polygonum multiflorum are improved; a technical support is provided for efficient separation and purification of the stibene glucoside in the polygonum multiflorum and other phenolic compounds. The phenolic hydroxyl modified adsorption resin has high selectivity, high adsorption capacity, high absorption efficiency and high resolution efficiency for the stibene glucoside in the polygonum multiflorum, and a high-purity stibene glucoside monomer component can be obtained through separation; the grafting ratio reaches 85.7 percent.

Description

technical field [0001] The invention belongs to the technical field of functional polymer adsorption resins, and in particular relates to a macroporous adsorption resin modified with phenolic hydroxyl groups and its application. Background technique [0002] Polygonum multiflorum is the root tuber of Polygonum multiflorum, one of the traditional Chinese medicinal materials, which has been widely used for nourishing and anti-aging therapeutic applications for a long time. The stilbene glycosides in Polygonum multiflorum have unique functions in anti-oxidation, preventing Alzheimer's disease, protecting the cardiovascular system, reducing hyperlipidemia and inhibiting tumors, which have important research and development value in today's aging society. [0003] How to efficiently separate and purify stilbene glycosides from Radix Polygonum multiflorum is the primary problem that needs to be solved urgently. The separation and purification techniques of stilbene glycosides ...

Claims

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Application Information

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IPC IPC(8): B01J20/26B01J20/30C08F212/36C08F8/00C07H15/18C07H1/08
Inventor 徐溢张晓凤
Owner CHONGQING UNIV
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