Breast injection medicament for resisting cow mastitis and preparation method thereof

A mastitis and breast technology, applied in the direction of anti-inflammatory agents, antibacterial drugs, pharmaceutical formulas, etc., can solve the problems of low cure rate of dairy cow mammary gland diseases, residual time of drugs, and affecting milk quality, etc., to reduce body weight The effect of increasing the number of cells, less residue, and improving the cure rate

Active Publication Date: 2015-05-20
JIANGXI BOLAI PHARMACY CO LTD
View PDF5 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the drugs used in the lactation period generally have residues and the residue time is long, which will affect the quality

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Breast injection medicament for resisting cow mastitis and preparation method thereof
  • Breast injection medicament for resisting cow mastitis and preparation method thereof
  • Breast injection medicament for resisting cow mastitis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] In this example, the specific dosage of the raw materials for producing 100 ml of the udder injection agent for cow mastitis is prepared according to the following table 1. The specific preparation method is: heating 30-35% of the total amount of cottonseed oil, and then the oil Acid macrogol glyceride, methyl paraben, microcrystalline paraffin and vitamin E are added to cottonseed oil and stirred evenly until they are completely dissolved to form the first mixture, and then the three major ingredients ceftiofur hydrochloride, cloxacillin sodium, prednisolone and 10-20% of the total amount of cottonseed oil are mixed and stirred evenly to form the second mixture, then the first mixture and the second mixture are mixed and stirred evenly, then the remaining cottonseed oil is added and emulsified for a period of time After cooling, subpackage, each 10ml.

[0034] Table 1 raw material consumption

[0035] Unit: g

[0036]

[0037] The udder injection medicament of thi...

Embodiment 2

[0042] In this example, the specific amount of raw materials for the udder injection of 100 ml of dairy cow mastitis is formulated according to the following table 2. The specific preparation method is: 30-35% of the total amount of cottonseed oil is mixed at 60-70 ° C. Under heating, then these additives of macrogol glycerol oleate, methylparaben, microcrystalline paraffin, vitamin E and sodium bisulfite are added to the cottonseed oil at a rate of 200-300rad / min Stir evenly until the first mixture is completely dissolved, then mix and stir 10-20% of the three major ingredients ceftiofur hydrochloride, cloxacillin sodium, prednisolone and the total amount of cottonseed oil to form the second mixture, and then Mix the first mixture and the second mixture at a speed of 200-300rad / min, then add the remaining cottonseed oil, stir for 30 minutes with a shear emulsifier, then cool and distribute, each 10ml.

[0043] Table 2 raw material consumption

[0044] Unit: g

[0045]

...

Embodiment 3

[0048] In this example, the specific dosage of the raw materials for every 100ml of milk cow mastitis injection medicine produced is formulated according to the following table 3. The specific preparation method is: 30-35% of the total amount of cottonseed oil is mixed at 60-70°C Under heating, then several additives such as polyethylene glycol 4000, polyethylene glycol 6000, ethyl paraben, liquid paraffin, vitamin E and sodium metabisulfite are added to the cottonseed oil at a rate of 200-300rad / min Stir evenly until the first mixture is completely dissolved, then mix and stir 10-20% of the three major ingredients ceftiofur hydrochloride, cloxacillin sodium, prednisolone and the total amount of cottonseed oil to form the second mixture, and then Mix the first mixture and the second mixture at a speed of 200-300rad / min, then add the remaining cottonseed oil, stir for 30 minutes with a shear emulsifier, then cool and distribute, each 10ml.

[0049] Table 3 raw material consumpt...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides a breast injection medicament for resisting cow mastitis and a preparation method thereof. The breast injection medicament comprises raw materials and a cosolvent, wherein the raw materials include active ingredients and auxiliary materials; the active ingredients include the following components in parts by weight: 0.5-2.0 parts of ceftiofur hydrochloride, 1-10 parts of cloxacillin sodium and 0.05-0.25 part of prednisolone; the auxiliary materials include the following components in parts by weight: 0.5-2 parts of dispersing agent, 0.15-2 parts of antioxidant, 0.05-0.5 part of preservatives and 1-7 parts of emulsifier; and the cosolvent is cottonseed oil. The method comprises the following steps: heating 30-35% of total amount of cottonseed oil, adding the antioxidant, the preservatives, the emulsifier and the dispersing agent into the cottonseed oil, and stirring; mixing ceftiofur hydrochloride, cloxacillin sodium and prednisolone and 10-20% of total amount of cottonseed oil; mixing the mixture, adding the remaining cottonseed oil, emulsifying and cooling and subpackaging. The breast injection medicament has the effects of being fewer for in vivo residues, short in retention time, and good in healing effect on cow mastitis disease, and the like.

Description

technical field [0001] The invention relates to the field of preparation of veterinary medicines, in particular to a udder injection medicament for resisting cow mastitis and a preparation method thereof. Background technique [0002] Mastitis is the most common type of disease in dairy cows. It is an international problem. It is a kind of inflammation of breast tissue and nipples caused by the local blood circulation disorder of the breast, which leads to low immune function and cannot completely resist the invasion and proliferation of pathogenic microorganisms. Common disease. The pathogens that cause mastitis are Streptococcus, Staphylococcus aureus, Escherichia coli and Mycoplasma, among which the most important pathogens are Streptococcus agalactiae and Staphylococcus aureus, and colibacillosis is also more and more common in intensive dairy farms. more serious. Cow mastitis is an important disease that seriously affects the development of the dairy industry. The dis...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/573A61P29/00A61P15/14A61P31/04A61K31/431A61K31/546
Inventor 毛娉婷唐进波熊俊芳肖欣戈万成
Owner JIANGXI BOLAI PHARMACY CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap