Plant polysaccharide cleaning fluid

A plant polysaccharide and cleaning liquid technology, which is applied in the field of medicine and achieves the effects of meeting clinical application requirements, product stability and simple preparation process

Active Publication Date: 2015-05-20
河北柯瑞生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far there is no report on the use of sodium carboxymethylcellulose in intestinal cleansing

Method used

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  • Plant polysaccharide cleaning fluid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1~6

[0020] Using sodium carboxymethyl cellulose with different mass percentages and different degrees of substitution as raw materials, the process of preparing plant polysaccharide cleaning liquid: take carboxymethyl cellulose sodium as shown in Table 1, and mix carboxymethyl cellulose with stirring. Sodium cellulose is dissolved in water for injection. After fully dissolving, add 9g of sodium chloride, 0.811g of potassium dihydrogen phosphate, and 0.189g of sodium hydroxide, fully stir and dissolve, and finally make up to 1000ml with water for injection, measure the pH value, and filter , the filtrate is filled and sealed, and steam sterilized at 121°C for 30 minutes.

[0021] Table 1 Determination of parameters of sodium carboxymethyl cellulose

[0022] .

Embodiment 7~9

[0024] The preparation process of further adding carboxymethyl chitosan plant polysaccharide cleaning solution: take by weighing 5 g of sodium carboxymethyl cellulose with a degree of substitution of 0.62, and dissolve sodium carboxymethyl cellulose in water for injection under stirring, and wait until fully After dissolving, add 9g of sodium chloride, 0.811g of potassium dihydrogen phosphate, 0.189g of sodium hydroxide, carboxymethyl chitosan, fully stir and dissolve, and finally make up to 1000ml with water for injection, measure the pH value, filter, and fill the filtrate Seal; sterilize by steam at 121°C for 30 minutes, ready to serve. The amount of carboxymethyl chitosan added is shown in Table 2.

[0025] Table 2 Addition amount of carboxymethyl chitosan

[0026] .

Embodiment 10~13

[0028] The preparation process of the plant polysaccharide cleaning liquid further adding magnesium chloride: Weigh 5 g of sodium carboxymethyl cellulose with a degree of substitution of 0.62, and dissolve sodium carboxymethyl cellulose in water for injection under stirring. After fully dissolving, add Sodium chloride 9g, potassium dihydrogen phosphate 0.811g, sodium hydroxide 0.189g, magnesium chloride and carboxymethyl chitosan 4g, fully stirred to dissolve, finally make up to 1000ml with water for injection, measure the pH value, filter, fill and seal the filtrate ; 121 ℃ steam sterilization for 30 minutes, that is. The amount of magnesium chloride added is shown in Table 3.

[0029] Table 3 The amount of magnesium chloride added

[0030] .

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Abstract

The invention relates to a plant polysaccharide cleaning fluid, which is used for intestinal lavage, and takes sodium carboxymethylcellulose as a main ingredient. The plant polysaccharide cleaning fluid comprises the following components in percent by mass: 0.1%-2% of sodium carboxymethylcellulose, 0.7%-1.2% of sodium chloride, 0.01%-0.1% of pH value buffer substances, 0.1%-5% of selectable magnesium chloride, 1%-10% of selectable mannitol, 0.01%-0.1% of selectable phenolphthalein and 0.1%-0.4% of selectable carboxymethyl chitosan, and the balance of water for injection, wherein the pH value of the polysaccharide cleaning fluid ranges from 6.5-7.8. The polysaccharide cleaning fluid is good in cleaning effect, free from adverse effect, and the cleaning fluid is stable and difficult to degrade.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a cleaning solution mainly composed of sodium carboxymethyl cellulose for intestinal cleaning. Background technique [0002] Before colonoscopy, enema X-ray examination or colon surgery, oral medication or enema is generally used for intestinal cleansing. Oral medicine has a special smell and salty taste, accompanied by severe diarrhea, which is unbearable for patients. Enema is generally to inject normal saline or glycerin into the intestine from the anus to soften the stool and facilitate the excretion of stool. However, the effect of normal saline is slow and the cleaning is not thorough. Hypertonic solutions such as glycerin have many side effects, which can easily cause abdominal pain, bloating, Even cause serious adverse reactions such as dehydration. [0003] The raw material of sodium carboxymethyl cellulose is natural plant fiber, which is safe and reliabl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/717A61P1/10
Inventor 李素哲董科刘媞刘俊英李璟
Owner 河北柯瑞生物医药有限公司
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