Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of copolymer nanosphere based on hydrophobic monomer and preparation method thereof

A technology of hydrophobic monomers and nano-microspheres, which is applied in the field of nano-microspheres and their preparation, to achieve the effects of simple process, good uniformity of particle size distribution, and improvement of cell adhesion and proliferation

Active Publication Date: 2018-01-19
DONGHUA UNIV
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hellweg et al. (Hertle Y, Zeiser M, Hasenohrl C, Busch P, Hellweg Y. Colloid Polym Sci. 2010; 288:1047-1059) prepared a series of copolymers of NIPAm and NtBA by soap-free emulsion polymerization, using different However, these studies are based on NIPAm as the main monomer, introducing NtBA or other monomers for copolymerization, and there are few reports on the preparation of NtBA as the main monomer to study its copolymer.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of copolymer nanosphere based on hydrophobic monomer and preparation method thereof
  • A kind of copolymer nanosphere based on hydrophobic monomer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (1) Take 0.7688g NtBA (dissolved in 3g ethanol), 0.0368g NIPAm, 0.02g crosslinker N,N'-methylenebisacrylamide and 0.04g emulsifier sodium lauryl sulfate dissolved in 100g deionized water, and bubble N at room temperature 2 Deoxygenation, magnetic stirring for 90 minutes;

[0021] (2) The reaction temperature rises to 60°C, and under N 2 Keep warm for 30 minutes under protection;

[0022] (3) Take 0.06g of ammonium persulfate and add it to the above solution to keep N 2 atmosphere, continue to react for 3 hours;

[0023] (4) Then soak the obtained reactant in deionized water and dialyze for 7 days, change the water once a day to remove residual reaction raw materials and electrolytes in the reaction system. The molecular weight cut-off of the dialysis bag used is 8000-14000. Instantly.

Embodiment 2

[0025] (1) Take 0.6861g NtBA (dissolved in 3g ethanol), 0.1103g NIPAm, 0.02g crosslinker N,N'-methylenebisacrylamide and 0.04g emulsifier sodium lauryl sulfate dissolved in 100g deionized water, and bubble N at room temperature 2 Deoxygenation, magnetic stirring for 90 minutes;

[0026] (2) The reaction temperature rises to 60°C, and under N 2 Keep warm for 30 minutes under protection;

[0027] (3) Take 0.06g of ammonium persulfate and add it to the above solution to keep N 2 atmosphere, continue to react for 3 hours;

[0028] (4) Then soak the obtained reactant in deionized water and dialyze for 7 days, change the water once a day to remove residual reaction raw materials and electrolytes in the reaction system. The molecular weight cut-off of the dialysis bag used is 8000-14000. Instantly.

Embodiment 3

[0030] (1) Take 0.7688g NtBA (dissolved in 3g ethanol), 0.0368g NIPAm, 0.02g crosslinker N,N'-methylenebisacrylamide and 0.08g emulsifier sodium lauryl sulfate dissolved in 100g deionized water, and bubble N at room temperature 2 Deoxygenation, magnetic stirring for 90 minutes;

[0031] (2) The reaction temperature rises to 60°C, and under N 2 Keep warm for 30 minutes under protection;

[0032] (3) Take 0.06g of ammonium persulfate and add it to the above solution to keep N 2 atmosphere, continue to react for 3 hours;

[0033] (4) Then soak the obtained reactant in deionized water and dialyze for 7 days, change the water once a day to remove residual reaction raw materials and electrolytes in the reaction system. The molecular weight cut-off of the dialysis bag used is 8000-14000. Instantly.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
lower critical solution temperatureaaaaaaaaaa
Login to View More

Abstract

The present invention relates to a kind of copolymer nano-microsphere based on hydrophobic monomer and preparation method thereof, the copolymer nano-microsphere is: poly(N-tert-butylacrylamide-co-N-isopropylacrylamide) P( NtBA-co-NIPAm) nanospheres or poly(N-tert-butylacrylamide-co-acrylic acid)P(NtBA-co-AAc) nanospheres. Dissolve monomer A in a solvent, monomer B or monomer C, cross-linking agent and emulsifier in deionized water, after mixing, stir and react for 80-120min in a nitrogen atmosphere at 20-25°C, Then raise the temperature to 25-80°C, keep warm at 30-50°C, then add the initiator, continue the reaction for 0.5-4h, and dialyze to obtain the product. The method adopted in the invention has a simple process, and by changing the preparation conditions, the adjustment of the size of the microspheres can be realized, and at the same time, the uniformity of the particle size distribution of the microspheres can be ensured.

Description

technical field [0001] The invention belongs to the field of nano microspheres and their preparation, in particular to a hydrophobic monomer-based copolymer nano microspheres and a preparation method thereof. Background technique [0002] Polymer nanospheres mainly refer to microspheres polymerized from related monomers with a size in the nanometer range, generally less than 100nm in size and uniformly distributed. Due to the special size of polymer nanospheres, they have a wide range of application values ​​in standard metrology, applied and analytical chemistry, chemical industry, especially in biomedicine, and their preparation methods have also attracted much attention. [0003] The preparation method of temperature-sensitive N-substituted acrylamide nanospheres has attracted much attention, and the most representative one is poly-N-isopropylacrylamide (PNIPAm) microspheres, whose lower critical solution temperature (LCST) is about It is 32°C, which is close to human bo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/54C08F220/06C08F2/26
Inventor 鲁希华李雪婷安冬马天泽邱高
Owner DONGHUA UNIV
PatSnap Eureka logo

PatSnap Eureka turns technology decisions into work you can execute. Powered by our Innovation Knowledge Graph, it runs expert workflows across engineering, life sciences, materials and intellectual property. Get your review-ready output in minutes.

X (Twitter)LinkedInYouTubeSubstack

© 2026 PatSnap. All rights reserved. 

Terms of Service

 | 

Privacy policy

 | 

Modern Slavery Act Transparency Statement