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Externally used pharmaceutical composition, preparation method and application thereof

A technology of external drug and composition, applied in the field of external drug composition, to achieve the effect of inhibiting bacterial growth, fine and uniform texture, and stable quality

Active Publication Date: 2015-06-10
GOODDOCTOR ZHONGZANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patent CN102861116 discloses a method for preparing pomegranate peel polyphenol gel for treating gynecological inflammation, and the prepared gel is used to prevent and treat gynecological inflammation vaginitis and cervicitis caused by bacteria; patent CN102973608 discloses a The effective parts of the cockroach extract are used to prepare drugs for inhibiting fungal growth, and the prepared pharmaceutical preparations are used to prepare pharmaceutical preparations, medical devices, and daily chemical products for preventing and treating fungal infections; the disclosed gel preparation uses pomegranate peel polyphenols or Kangfuxin The preparation of the extract alone, and the gel prepared by loading Kangfuxin and pomegranate peel polyphenols have not been reported

Method used

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  • Externally used pharmaceutical composition, preparation method and application thereof
  • Externally used pharmaceutical composition, preparation method and application thereof
  • Externally used pharmaceutical composition, preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0029] The preparation of embodiment 1 pharmaceutical gel of the present invention

[0030] Preparation of polyphenol extract from pomegranate peel:

[0031] a. Take the pomegranate peel and grind it into a coarse powder, add 6 times the concentration of 65% ethanol to extract twice, each time for 1 hour, filter, combine the filtrate to recover ethanol under reduced pressure, and concentrate to a concentrated solution equivalent to 0.15g of crude drug per ml ;

[0032] b. Add the concentrated solution to the treated HPD100 macroporous adsorption resin column, absorb for 6 hours, first wash with deionized water until the color of the effluent is light, and then elute with 3 times the column volume of 60% ethanol, Collect the alcohol-containing eluate, recover ethanol, concentrate under reduced pressure, and vacuum-dry to form an extract, pulverize, pass through a 100-mesh sieve, and obtain a pomegranate peel polyphenol extract for later use, wherein the content of punicalagin ...

Embodiment 2

[0036] The preparation of embodiment 2 drug gel of the present invention

[0037] Preparation of polyphenol extract from pomegranate peel:

[0038] a. Take the pomegranate peel and grind it into a coarse powder, add 5 times the concentration of 50% ethanol to extract once, each time for 2 hours, filter, combine the filtrate to recover ethanol under reduced pressure, and concentrate to a concentrated solution equivalent to 0.1g of crude drug per ml ;

[0039] b. Add the concentrated solution to the treated HPD100 macroporous adsorption resin column, absorb for 3 hours, wash with deionized water until the color of the effluent is light, and then elute with 40% ethanol with 2 times the column volume. Collect the alcohol-containing eluent, recover ethanol, concentrate under reduced pressure, and vacuum-dry to form an extract, pulverize, and pass through an 80-mesh sieve to obtain a pomegranate peel polyphenol extract for later use. The content of punicalagin in the extract is 10....

Embodiment 3

[0043] Embodiment 3 The preparation of drug gel of the present invention

[0044] Preparation of polyphenol extract from pomegranate peel:

[0045] a. Take the pomegranate peel and grind it into a coarse powder, add 10 times the concentration of 70% ethanol to extract 3 times, each time for 1 hour, filter, combine the filtrate to recover ethanol under reduced pressure, and concentrate to a concentrated solution equivalent to 0.2g of crude drug per ml ;

[0046] b. Add the concentrated solution to the treated HPD100 macroporous adsorption resin column, absorb for 10 hours, rinse with deionized water until the color of the effluent is light, and then elute with 70% ethanol of 6 times the column volume. Collect the alcohol-containing eluent, recover ethanol, concentrate under reduced pressure and vacuum-dry to form an extract, pulverize and pass through a 120-mesh sieve to obtain a polyphenol extract of pomegranate peel for later use, wherein the content of punicalagin in the ex...

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Abstract

The invention provides an externally used pharmaceutical composition, which is an externally used preparation prepared from a periplaneta Americana extract and a pomegranate peel polyphenol extract as the active ingredients. Specifically, the pomegranate peel polyphenol extract and the periplaneta Americana extract are in a weight ratio of 1:1-1:5. The invention also provides a preparation method of the externally used pharmaceutical composition. The externally used pharmaceutical composition is used for preventing and treating bacteria caused inflammation, repairing wounds and the like, and has the characteristics of convenient drug administration, good absorption and good curative effect.

Description

technical field [0001] The invention relates to a pharmaceutical composition for external use. Background technique [0002] As a traditional Chinese medicine, pomegranate peel has been recorded in all previous editions of Chinese Pharmacopoeia. It has the effects of astringent, antidiarrheal, hemostasis, and insect repellent. According to modern pharmacological studies, pomegranate peel also has antiviral, antibacterial, immune regulation, and antioxidant effects. , the tannins in the pomegranate peel have inhibitory effects on various bacteria and fungi because of the ability to solidify the protoplasm in the microorganism body and the influence on various enzymes. Bacillus, Aspergillus niger, Pseudomonas aeruginosa, Candida albicans, etc. all have good antibacterial effects. At the same time, it has been clinically proved that pomegranate peel has obvious inhibitory effect on Neisseria gonorrhoeae, and has broad-spectrum antibacterial properties. [0003] Fufuxin is an e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K47/38A61K47/32A61K9/06A61P31/04A61P17/02A61K35/64
Inventor 舒梅
Owner GOODDOCTOR ZHONGZANG PHARMA
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