Formamide preparation method

Abstract

The invention relates to a formamide preparation method. The method allows the product formamide to prepared from a formylating reagent and amine (primary amine or secondary amine) through a formylating reaction under the promotion of an acidic gas. The method is characterized in that the formylating reaction is efficiently carried out under mild conditions with the acidic gas as a reaction promoter. The method comprises the following steps: mixing a certain concentration of the formylating reagent with the primary amine or secondary amine without adding other solvents, introducing a certain amount of the acidic gas, sealing, stirring at a temperature higher than room temperature, and reacting for 0.5h or more to obtain the product formamide. The method has the advantages of high controllability and no addition of a catalyst in the reaction process; the promoter is a gas and rapidly volatilizes when the reaction ends, so separation is not needed; the yield of the product formamide reaches above 95%; and the promoter has very good substrate universality.

Description

Technical field [0001] The invention relates to a method for preparing formamide, in particular to a process for preparing formamide through a formamide reaction promoted by acid gas. Background technique [0002] Amide group is a very important chemical group that exists in many natural polymers, such as: peptides, proteins, etc. In addition, amide is also an excellent synthetic monomer and can be used to prepare polymers such as nylon. CN101970675A discloses a method for biocatalyzing nitrile compounds to prepare amide compounds. A patent of BASF Europe (CN102712576A) uses phosphoric acid or Lewis acidic metal salt as a catalyst to catalyze the conversion of a series of amines and formate esters to prepare aromatic formamides. Patent CN101684076B uses amino acid ionic liquid as reaction medium and catalyst to catalyze the Beckmann rearrangement reaction of ketoxime to prepare amide. [0003] Although there are many studies on the preparation methods of amides, there are some d...

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Problems solved by technology

[0003] Although there are many studies on the preparation methods of amides, there are some disadvantages: for example, the catalyst preparation process is complicated, the reaction time is long, the reaction yield is low, the environment is polluted, and the catalyst is easily deactivated after the reaction.

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