Novel potassium citrate sustained release tablet and preparation method thereof

A technology of potassium citrate and sustained-release tablets, which is applied to medical preparations with no active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, and can solve problems such as potassium citrate sustained-release tablets. Achieve the effect of good drug stability and high bioavailability

Inactive Publication Date: 2015-07-01
GUANGZHOU PHARMACEUTICAL INDUSTRIAL RESEARCH INSTITUTE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the classification of slow and controlled release preparations is: matrix slow and controlled release technology, osmotic pump technology, film coating slow and controlled release technology, among which matrix slow and controlled release technology is widely used, and matrix slow and controlled release technology is divided into hydrophilic Gel skeleton, insoluble skeleton, and membrane-controlled skeleton, potassium citrate is a drug that is very soluble in water. At present, there is no relevant report on the preparation of potassium citrate sustained-release tablets using erodible skeletons

Method used

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  • Novel potassium citrate sustained release tablet and preparation method thereof
  • Novel potassium citrate sustained release tablet and preparation method thereof
  • Novel potassium citrate sustained release tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The percentage in the prescription is the percentage by weight of the component in the whole prescription, and the percentage of lipid material is calculated by the weight of the granules containing the drug, which is the same in the following examples.

[0037]

[0038]

[0039] To prepare potassium citrate extended-release tablets:

[0040] Step 1: Crushing: put potassium citrate, microcrystalline cellulose, hypromellose, and talc into the pulverizer respectively, start the machine, and make the powder into a powder that meets the requirements of an 80-mesh sieve;

[0041] Step 2: Ingredients weighing: check the raw and auxiliary materials sent according to the preparation instruction list, and carry out ingredient weighing;

[0042] Step 3: Granulation: Add lipid material / porogen with wetting agent, heat, stir / homogenize to form lipid liquid, and set aside; Stir the lipid liquid until it reaches the point where it forms a ball and disperses when touched, and t...

Embodiment 2

[0049]

[0050]

[0051] To prepare potassium citrate extended-release tablets:

[0052] Step 1: Crushing: put potassium citrate, starch, hypromellose, and talc into the pulverizer respectively, start the machine, and make the powder material to meet the requirements of 80-mesh sieve;

[0053] Step 2: Ingredients weighing: check the raw and auxiliary materials sent according to the preparation instruction list, and carry out ingredient weighing;

[0054] Step 3: Granulation: Add lipid material / porogen with wetting agent, heat, stir / homogenize to form lipid liquid, and set aside; Stir the lipid liquid until it reaches the point where it forms a ball and disperses when touched, and then it can be discharged;

[0055] Step 4: Drying: Immediately place the granules in an air-heated drying oven, dry, and discharge;

[0056] Step 5: Grain sizing: pass the dried granules through a 20-50 mesh sieve, and the 20-50 mesh sieve is the qualified granule;

[0057] Step 6: Tablet co...

Embodiment 3

[0061]

[0062]

[0063] To prepare potassium citrate extended-release tablets:

[0064] Step 1: Crushing: put potassium citrate, lactose, hypromellose, and talc into the pulverizer respectively, start the machine, and make the powder into a 80-mesh sieve;

[0065] Step 2: Ingredients weighing: check the raw and auxiliary materials sent according to the preparation instruction list, and carry out ingredient weighing;

[0066] Step 3: Granulation: Add lipid material / porogen with wetting agent, heat, stir / homogenize to form lipid liquid, and set aside; Stir the lipid liquid until it reaches the point where it forms a ball and disperses when touched, and then it can be discharged;

[0067] Step 4: Drying: Immediately place the granules in an air-heated drying oven, dry, and discharge;

[0068] Step 5: Grain sizing: pass the dried granules through a 20-50 mesh sieve, and the 20-50 mesh sieve is the qualified granule;

[0069] Step 6: Tablet compression: perform tablet com...

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Abstract

The invention provides a novel potassium citrate sustained release tablet and a preparation method thereof, the preparation method comprises the steps of crushing, weighing raw materials, granulating, mixing and tabletting. The potassium citrate sustained release tablet comprises the following components: potassium citrate, a lipid material (monoglyceride stearate, glycerol distearates, glyceryl behenate, glyceryl palmitate-stearate, glycerol trilaurate, neodecanoic acid glyceride, stearic acid, palmitic acid, beeswax), lactose and microcrystalline cellulose. The potassium citrate sustained release tablet is prepared by the components by weight percentage: 1-50% of potassium citrate, 10-50% of lipid material, 10-70% of filler, 0-60% of wetting agent, 0.1-5% of adhesive and 0.1-2% of antitackiness agent. The potassium citrate sustained release tablet has the advantages of the quality is good, medicine release is alleviated, and biology utilization degree is increased.

Description

technical field [0001] The invention relates to a new sustained-release potassium citrate tablet and a preparation method thereof, belonging to the technical field of pharmacy. Background technique [0002] [0003] Potassium Citrate, the chemical name is 2-hydroxypropane-1,2,3-carboxylate potassium, and its molecular formula is C 6 h 5 K 3 0 7 .H 2 O, molecular weight 324.41; colorless crystal or white crystalline powder, slightly hygroscopic, easily soluble in water, slowly soluble in glycerin, insoluble in alcohol, taste salty and cool. [0004] Urinary system stones seriously endanger human health. According to different geographical environments, the incidence rate is 3% to 15%, and the incidence rate increases year by year. After treatment, it is easy to recur, and the recurrence rate is as high as 50% in 10 years. Potassium citrate sustained-release tablets were clinically used in the United States in 1985. It is a strong alkalizing agent, which improves the e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/194A61K47/44A61K47/14A61K47/12A61P13/04
Inventor 梁超峰刘英黄韵然郭晓娟黄春晖
Owner GUANGZHOU PHARMACEUTICAL INDUSTRIAL RESEARCH INSTITUTE
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