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A kind of Ganfule soft capsule and preparation method thereof

A technology of soft capsules and Ganfule, applied in capsule delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as unsatisfactory curative effect, further research is still needed, and low effective rate of liver cancer, so as to achieve market development Good prospects, good patient compliance, and scientific and reasonable data ratio

Active Publication Date: 2020-01-10
KAMP PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, 90% of patients lost the chance of surgery due to large tumors or liver cirrhosis; normal liver cells are sensitive to radiation, while liver cancer cells are less sensitive, requiring > 4000cGy to obtain certain local control; local ablation therapy can achieve local Tumor control, symptom relief, etc. can be used as a treatment option for patients who cannot accept surgical resection, but it is only effective for liver cancer with tumors smaller than 5cm; the partial remission rate of chemotherapy drugs for liver cancer is below 20%, and the curative effect is not ideal; Catheter chemoembolization (TACE) or TACE plus portal vein embolization (PVE) has improved the effective rate and improved the survival time, but further studies are needed in terms of whether the arterial embolization is complete, the best drug combination, and the best embolization model. Research; the effective rate of biological targeted therapy for primary liver cancer is less than 10%

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] (1) Ingredients and proportions of raw medicinal materials: Codonopsis 2-7%, Turtle Shell (made with vinegar) 0.5-5%, Chonglou 2-7%, Atractylodes macrocephala (stir-fried) 2-7%, Astragalus 2-7%, tangerine peel 2 -7%, ground beetle 0.5-5%, rhubarb 0.1-2%, peach kernel 1-6%, Scutellaria barbata 2-7%, Patrinia 2-7%, Poria cocos 2-7%, Coix seed 2-7% %, turmeric 2-7%, hematoxylin 2-7%, oyster 2-7%, capillary 2-7%, akebia 2-7%, Cyperus 2-7%, agarwood 0.5-3%, Bupleurum 1-5%.

[0053] (2) Extraction process of volatile oil: extract volatile oil from agarwood, Atractylodes macrocephala, tangerine peel, Patrinia, turmeric, capillary, Cyperus cyperi and Bupleurum, add water to 12 times, extract for 5 hours, collect volatile oil, and water extract And dregs spare.

[0054] (3) Alcohol extraction process: Carry out alcohol extraction of Codonopsis pilosula, Radix Astragali, Rhubarb, and Scutellaria barbata, the ethanol concentration is 55%, the alcohol addition ratio is 10 times, ...

Embodiment 2

[0066] (1) Ingredients and proportions of raw medicinal materials: Codonopsis 2-7%, Turtle Shell (made with vinegar) 0.5-5%, Chonglou 2-7%, Atractylodes macrocephala (stir-fried), Astragalus 2-7%, tangerine peel 2-7%, Ground Beetle 0.5-5%, Rhubarb 0.1-2%, Peach Kernel 1-6%, Banzhilian 2-7%, Patrinia 2-7%, Poria 2-7%, Coix Seed 2-7%, Turmeric 2-7%, Sappan 2-7%, Oyster 2-7%, Capillary 2-7%, Chuan Akebia 2-7%, Cyperus 2-7%, Agarwood 0.5-3%, Bupleurum 1- 5%.

[0067] (2) Extraction process of volatile oil: extract volatile oil from agarwood, Atractylodes macrocephala, tangerine peel, Patrinia, turmeric, capillary, Cyperus cyperi and Bupleurum, add water to 12 times, extract for 5 hours, collect volatile oil, and water extract , The dregs of the medicine are for use.

[0068] (3) Water extraction process: decoct (2) traditional Chinese medicine dregs and Codonopsis pilosula and other medicinal materials, add water 10 times, extract time 2 hours, and extract twice.

[0069] (4) R...

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PUM

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Abstract

The invention discloses a Ganfule softgel and a preparation method thereof. The softgel comprises the steps of an essential oil extraction technology, a water extraction technology, an alcohol extraction technology, a refining technology, a volatile oil microcapsule preparation technology and a softgel preparation technology. According to the invention, through repeated test and improvement by an inventor, the data ratio is scientific and reasonable, the prepared Ganfule softgel has the advantages of rapid disintegration, good targeting and definite therapeutic effect, the content of a main medicine is a great breakthrough in a primary liver cancer treatment field, and the Ganfule softgel has medical and market exploitation prospect.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a Ganfule soft capsule and a preparation method thereof. Background technique [0002] Liver cancer is a malignant tumor that originates from liver cells and intrahepatic biliary striata, also known as primary liver cancer. There are no obvious symptoms and signs at the beginning of the disease. With the development of the disease, progressive enlargement of the liver and gallbladder, pain, anorexia, fatigue, obvious weight loss, obvious fullness of the abdomen, jaundice, low fever and high fever appear. The etiology and pathogenesis of liver cancer: ①Invasion by evil poison, external evil poison invades the human body or muscle surface by taking advantage of the deficiency, or hides in the body, causing dysfunction of viscera and internal organs, qi reversed and disordered, leading to qi accumulation and blood coagulation over time. ② Emotional disorder, a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K36/9066A61P35/00A61K35/586A61K35/64A61K35/618
Inventor 曾培安曾灿丽吴健民贺莲张静刘娟
Owner KAMP PHARMA