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A kind of preparation method of double biomimetic polymer

A technology of polymer and polymerization reaction, applied in the field of preparation of dual biomimetic polymers, can solve problems such as difficulty in separation and purification, and achieve the effects of broad application prospect, simple preparation method and high grafting rate

Inactive Publication Date: 2017-08-25
XIAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although a dual biomimetic polymer with high and controllable dopamine content was synthesized by the active ester monomer approach, the active ester monomer needs to be prepared in an anhydrous environment, and its separation and purification are extremely difficult

Method used

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  • A kind of preparation method of double biomimetic polymer
  • A kind of preparation method of double biomimetic polymer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] This embodiment includes the following steps:

[0029] Step 1. Weigh 5mmol 2-methacryloyloxyethylphosphorylcholine and 5mmol glycidyl methacrylate, dissolve and mix them with a solvent to obtain a mixed solution of monomers, and mix 0.1mmol azobisisobutyronitrile Dissolved with tetrahydrofuran to obtain the initiator solution, in N 2 Protection, under the condition of stirring at 70°C, add the mixed solution of monomers into the three-necked flask, preheat for 30 minutes, add the initiator solution to continue the reaction for 24 hours, after the reaction is completed, concentrate the reaction solution, and use a dialyzer with a molecular weight cut-off of 6000-8000D bag dialysis; finally, freeze-dry the dialyzed sample at -50°C to obtain a phosphorylcholine polymer containing epoxy groups; the solvent is formed by mixing methanol and tetrahydrofuran at a volume ratio of 7:1; NMR test results show that the molar content of epoxy groups in the polymer is about 57.7%;

...

Embodiment 2

[0033] This embodiment includes the following steps:

[0034] Step 1. Weigh 7 mmol of acryloyloxyethyl phosphorylcholine and 3 mmol of glycidyl acrylate, dissolve and mix them with a solvent to obtain a mixed solution of monomers, and dissolve 0.1 mmol of azobisisobutyronitrile with tetrahydrofuran to obtain an initiator solution, in N 2 Protection, under the condition of stirring at 60°C, add the mixed solution of monomers into the three-necked flask, preheat for 30 minutes, add the initiator solution and continue the reaction for 24 hours. Dialyze the concentrated reaction solution in the bag; finally, freeze-dry the dialyzed sample at -50°C to obtain a phosphorylcholine polymer containing epoxy groups; the solvent is composed of methanol and tetrahydrofuran in a volume ratio of 6:1 It is mixed; NMR test results show that the molar content of epoxy groups in the polymer is about 39.2%;

[0035] Step 2, the phosphorylcholine polymer containing epoxy group described in 0.40m...

Embodiment 3

[0038] This embodiment includes the following steps:

[0039] Step 1. Weigh 6 mmol of 2-methacrylamide ethyl phosphorylcholine and 4 mmol of glycidyl acrylate, dissolve and mix them with a solvent to obtain a mixed solution of monomers, and dissolve 0.1 mmol of azobisisobutyronitrile in tetrahydrofuran to obtain Initiator solution, in N 2 Protection, under the condition of stirring at 80°C, add the mixed solution of monomers into the three-necked flask, preheat for 30 minutes, add the initiator solution and continue the reaction for 12 hours. Bag dialysis; finally, freeze-dry the dialyzed sample at -50°C to obtain a phosphorylcholine polymer containing epoxy groups; the solvent is formed by mixing methanol and tetrahydrofuran at a volume ratio of 8:1; NMR test results show that the molar content of epoxy groups in the polymer is about 48.1%;

[0040] Step 2, the phosphorylcholine polymer containing epoxy group described in 0.5mmol step 1 is dissolved in 20mL methanol to obta...

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Abstract

The invention discloses a preparation method of a double biomimetic polymer, comprising the following steps: 1. preparing a phosphorylcholine polymer containing an epoxy group; 2. dissolving the phosphorylcholine polymer containing an epoxy group In a polar solvent, a polymer solution is obtained, and under the protection of nitrogen, the polymer solution is heated to 35°C-70°C, then dopamine hydrochloride and acid-binding agent are added to the polymer solution, and the process is carried out under the condition of heat preservation and stirring. After the grafting reaction, a dialysis bag is used to dialyze the reaction product in an aqueous hydrochloric acid solution with a pH value of 3 to 4, and finally freeze-dry the dialyzed reaction product to obtain a double biomimetic polymer. The preparation method of the invention is simple, the conditions are mild, the grafting rate of dopamine is high, the molar content of dopamine groups in the prepared double biomimetic polymer is greater than 10%, and the adhesion is strong and difficult to fall off.

Description

technical field [0001] The invention belongs to the technical fields of material surface science and biomedical polymer materials, and in particular relates to a preparation method of a double biomimetic polymer. Background technique [0002] When the material is used in a living body, it is easy to non-specifically adsorb proteins, activate complement molecules and the immune system, thereby causing blood coagulation, immune and inflammatory reactions, resulting in a significant decrease in its performance or even failure. This is due to the poor biocompatibility of materials, therefore, biocompatibility research has become the primary issue in the field of biomaterial research. The surface of a material is the medium through which the material contacts the organism. Surface charge, hydrophilicity / hydrophobicity, chemical composition, and morphology are important factors that affect the interface interaction between the material and the organism, and determine whether the b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F230/02C08F220/32C08F8/32
Inventor 李赛
Owner XIAN UNIV OF SCI & TECH
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