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Zuojin microemulsion-based gel for treating stomachache and preparation method thereof

A technology of microemulsion gel and epigastric pain, which is applied in the field of pharmaceutical preparations, can solve problems such as poor stability, and achieve the effects of stable thermodynamic and kinetic properties and fast transdermal penetration rate

Active Publication Date: 2015-07-08
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, traditional Chinese medicine microgels also generally have the disadvantage of poor stability. Therefore, it is of great clinical significance to study the transdermal drug delivery system with systemic effects by local administration and to develop varieties for internal disease and external treatment.

Method used

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  • Zuojin microemulsion-based gel for treating stomachache and preparation method thereof
  • Zuojin microemulsion-based gel for treating stomachache and preparation method thereof
  • Zuojin microemulsion-based gel for treating stomachache and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Embodiment 1: the preparation of Zuojin microemulsion gel

[0069] Prepare Zuojin microemulsion gel according to the following process:

[0070] A. Weigh 0.7g of decoction pieces of Evodia rutaecarpa, extract the volatile oil by steam distillation, and store the obtained volatile oil in another container; concentrate the aqueous solution after oil extraction until the relative density at 50°C is in the range of 1.06-1.10, and use 1.5 times 95 Precipitate with % ethanol, filter, and keep the filtrate for use; Evodia rutaecarpa medicinal residues after extracting volatile oil are refluxed 3 times with 7 times the amount of 70% ethanol; combine the filtrates, and recover the ethanol until the relative density is within the range of 1.15-1.40;

[0071] B. Weigh 4.2g of Coptidis decoction pieces, reflux with 5 times the amount of 80% ethanol for 3 times, each time for 1.5 hours; filter, combine the filtrate, recover the ethanol until the relative density at 50°C is in the ra...

Embodiment 2

[0074] Embodiment 2: the preparation of Zuojin microemulsion gel

[0075] Prepare Zuojin microemulsion gel according to the following process:

[0076] A. Weigh 7g of decoction pieces of Evodia rutaecarpa, extract the volatile oil by steam distillation, and store the obtained volatile oil in another container; concentrate the aqueous solution after oil extraction until the relative density at 50°C is in the range of 1.06-1.10, and use 3 times 95% Precipitate with ethanol, filter, and keep the filtrate for use; the dregs of Evodia rutaecarpa after extracting the volatile oil are refluxed three times with 4 times the amount of 95% ethanol; combine the filtrates, and recover the ethanol until the relative density is within the range of 1.15-1.40;

[0077] B. Weigh 42g of Coptidis decoction pieces, reflux with 8 times the amount of 50% ethanol for 3 times, each time for 2 hours; filter, combine the filtrate, recover the ethanol until the relative density at 50°C is within the rang...

Embodiment 3

[0080] Embodiment 3: the preparation of Zuojin microemulsion gel

[0081] Prepare Zuojin microemulsion gel according to the following process:

[0082] A. Weigh 3.5g of decoction pieces of Evodia rutaecarpa, extract the volatile oil by steam distillation, and store the obtained volatile oil in another container; concentrate the aqueous solution after oil extraction until the relative density at 50°C is in the range of 1.06-1.10, and use 2 times 80 Precipitate with % ethanol, filter, and retain the filtrate; use 5 times the amount of 80% ethanol to reflux the medicinal residues of Evodia rutaecarpa after extracting the volatile oil for 3 times; combine the filtrates, and recover the ethanol until the relative density is within the range of 1.15-1.40;

[0083] B. Weigh 21g of Coptidis decoction pieces, reflux with 7 times the amount of 60% ethanol for 3 times, each time for 2 hours; filter, combine the filtrate, recover the ethanol until the relative density at 50°C is within th...

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Abstract

The invention relates to a zuojin microemulsion-based gel for treating stomachache and a preparation method thereof. Particularly, the Chinese herbal compound microemulsion-based gel comprises the following components in parts by weight: 0.1-1.0 part of zuojin extract, 100 parts of microemulsion matrix, and 100 parts of gel matrix, wherein the zuojin extract is prepared from coptidis rhizoma and fructus evodiae through extracting according to the weight ratio of 6:1; the microemulsion matrix is composed of the following components according to a weight ratio: 2.5-7.5% of oil phase (MCT), 5-25% of a surfactant (RH-40), 5-15% of a cosurfactant (PEG-400) and the balance of water; the gel matrix is composed of the following components according to a weight ratio: 0.3-2.0% of Carbo-mer, 0.5-2.0% of hydroxypropyl methyl cellulose, 0.6-1.8% of povidone, 5-25% of polyethylene glycol-400, 0.3-1.2% of triethanolamine, 0.03-0.08% of sodium bisulfite, 0.02-0.05% of ethylenediamine tetraacetic acid disodium salt and balance of water. The zuojin microemulsion-based gel has no irritation and irritability, has a higher percutaneous penetration rate, is more stable, is suitable for being applied externally and can achieve the effect of treating the internal illness by external treatment.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations. Specifically, the present invention relates to a traditional Chinese medicine compound microemulsion gel preparation (ie Zuojin microemulsion gel) for the treatment of epigastric pain that can increase the rate of transdermal absorption and its preparation method. Background technique [0002] The traditional Chinese medicine prescription of the present invention is derived from the Zuojin pill recorded in the first volume of the Chinese Pharmacopoeia. Zuojin Wan is mainly used clinically for purging fire, soothing liver, harmonizing stomach and relieving pain. According to the theory of "internal disease external treatment" in traditional Chinese medicine, the present invention changes it into microemulsion gel, and treats the disease of "epigastric pain" in traditional Chinese medicine by transdermal administration. The key point of its technology is to improve the percutaneous abso...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K36/754A61P1/00A61P1/04
Inventor 刘淑芝梁日欣易红冯伟红杜茂波王岚杨华梅莹成龙胡楠杨菲
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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