based on au-fe 3 o 4 Melamine dual-mode sensor based on composite nanoparticles and its preparation

A technology of composite nanoparticles and melamine, applied in the direction of color/spectral characteristic measurement, material magnetic variable, etc., can solve problems such as urine can not be discharged smoothly, renal tubule obstruction, kidney failure, etc., to achieve shortened detection cost, high selectivity, Strong anti-interference ability

Inactive Publication Date: 2017-08-15
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the human body cannot convert these two substances, finally melamine and cyanuric acid are transported by the blood to the kidneys, where the two substances meet, and through the interaction of hydrogen bonds, re-form a water-insoluble macromolecular complex in a grid structure, and Deposits, forming stones, result in a physical blockage of the kidney tubules, which prevents the urine from being excreted smoothly, accumulates water in the kidneys, and eventually leads to kidney failure

Method used

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  • based on au-fe <sub>3</sub> o <sub>4</sub> Melamine dual-mode sensor based on composite nanoparticles and its preparation
  • based on au-fe <sub>3</sub> o <sub>4</sub> Melamine dual-mode sensor based on composite nanoparticles and its preparation
  • based on au-fe <sub>3</sub> o <sub>4</sub> Melamine dual-mode sensor based on composite nanoparticles and its preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] (1) Preparation of specific receptor unit.

[0059] (1.1) Take 1.42 mL of ethyl isothiocyanate (12 mmol) and dissolve it in 100 mL of acetone.

[0060] (1.2) Take 1.022g of 2-amino-2-thiazoline (10mmol) and dissolve it in 200mL of CH 2 Cl 2 middle.

[0061] (1.3) The solution obtained in step (1.2) was slowly added dropwise to the solution obtained in step (1.1), and the obtained mixed solution was heated to 50° C. for 0.5 h to obtain a precipitate, filtered and washed with acetone. get

[0062] (1.4) Take 2.00g (10.7 mmol) was added to 100 mL of 18% HCl, heated to reflux for 6.5 h under argon atmosphere, and H was detected with lead acetate test paper during the reaction. 2 S, after the reaction is completed, cool, filter, and dry to obtain a white solid specific receptor unit

[0063] specific receptor unit 1 H NMR spectrum as figure 1 shown. figure 1 middle,

[0064] 1 H NMR (DMSO-d 6 ): δ=2.66(m,3,CH 2 S+SH), δ=3.77(m,2,CH 2 N), δ=11.45(s, 2, 2NH)...

Embodiment 2

[0076] (1) The preparation of the specific receptor unit is the same as that of Example 1.

[0077] (2) Au-Fe 3 O 4 The preparation of nanoparticles is the same as in Example 1.

[0078] (3) Based on Au-Fe 3 O 4 Fabrication of a dual-mode sensor for nanoparticle detection of melamine.

[0079] Take 0.1g NOBF 4 Dissolve in 10 mL DMF and dissolve by sonication. Take ~50mg Au-Fe 3 O 4 The nanoparticles were dispersed in 10 mL of n-hexane and mixed well. put NOBF 4 DMF solution added to Au-Fe 3 O 4 In the n-hexane solution of the nanoparticles, shake and shake, the nanoparticles are put into the DMF solution, and centrifuged with n-hexane and toluene (1:1). Disperse into DMF. Then 20 mg of specific receptor units were added, and the reaction was shaken on a shaker for 48 hours. Obtaining Au-Fe that modifies the acceptor unit by coordination 3 O 4 Nanoparticles in DMF solution, dialyzed for 72 hours.

[0080] The shaking time is 3-5 min.

Embodiment 3

[0082] (1) The preparation of the specific receptor unit is the same as that of Example 1.

[0083] (2) Au-Fe 3 O 4 The preparation of nanoparticles is the same as in Example 1.

[0084] (3) Based on Au-Fe 3 O 4 Fabrication of dual-mode sensor for detection of melamine by nanoparticles

[0085] Take 0.1g NOBF 4 Dissolve in 10 mL DMF and dissolve by sonication. Take ~100mg Au-Fe 3 O 4 The nanoparticles were dispersed in 10 mL of n-hexane and mixed well. put NOBF 4 DMF solution added to Au-Fe 3 O 4 In the n-hexane solution of the nanoparticles, shake and shake, the nanoparticles are put into the DMF solution, and centrifuged with n-hexane and toluene (1:1). Disperse into DMF. Then 20 mg of specific receptor units were added, and the reaction was shaken on a shaker for 24 hours. Obtaining Au-Fe that modifies the acceptor unit by coordination 3 O 4 Nanoparticles in DMF solution, dialyzed for 72 hours.

[0086] The shaking time is 3-5 min.

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Abstract

The invention relates to a melamine dual-mode sensor based on Au-Fe3O4 composite nanoparticles and a preparation method thereof. The invention relates to the field of nuclear magnetic resonance sensing. First, oleylamine oleic acid on the surfaces of the Au-Fe3O4 composite nanoparticles is stripped through NOBF4; and a specific receptor unit modifies the surfaces of the composite nanoparticles stripped by NOBF4 under the strong coordination effect of an Au-S bond, thus obtaining target composite nanoparticles which can be used for preparing the melamine dual-mode sensor. Compared with prior art, the dual-mode sensor provided by the invention has the advantages that in the presence of melamine, dispersed-state nanoparticles are induced to aggregate so that the transverse relaxation time of water protons around the nanoparticles and the ultraviolet absorption spectrum of the nanoparticles are changed. According to the sensor, melamine is detected with both an ultraviolet absorption spectrum method and a nuclear magnetic resonance method; therefore, the sensor has the advantages of wide application range, high selectivity and high interference resistance. A method is provided for realizing fast application under different actual situations.

Description

technical field [0001] The invention relates to the field of nuclear magnetic resonance sensing, in particular to an Au-Fe-based 3 O 4 A composite nanoparticle-based melamine dual-mode sensor and its preparation method and application. Background technique [0002] A sensor is a device or device that can accept a prescribed measurement and convert it into a useful signal according to a certain law. Sensors can be divided into three categories, namely physical sensors, chemical sensors and biosensors. A physical sensor is a sensor that detects physical quantities. It is a device that uses certain physical effects to convert the measured physical quantity into a signal in the form of energy that is easy to process. The output signal has a definite relationship with the input signal. The main physical sensors include photoelectric sensors, piezoelectric sensors, piezoresistive sensors, electromagnetic sensors, pyroelectric sensors, optical fiber sensors, etc. Chemical sens...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/33G01N27/72
Inventor 杨仕平沈金超杨红周治国张钖杨艳
Owner SHANGHAI NORMAL UNIVERSITY
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