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Multi-vitamin dispersible tablet

A technology of multi-dimensional elements and dispersible tablets, applied in the directions of inorganic active ingredients, organic active ingredients, active ingredients of iodine compounds, etc., can solve the problems of difficulty, unstable main drug, and many main components of multi-dimensional element tablets, and improve product quality. , Coordinate the effect of enhancing immunity and fast disintegration

Active Publication Date: 2015-07-22
ZHEJIANG SHENGBOKANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to the large number of main ingredients in multidimensional element tablets, some of the main ingredients are unstable under hot and humid conditions, so it is difficult to prepare tablets with rapid and stable release.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Select the WP50N / 75 roller press manufactured by Alexander Company in Germany;

[0034] The water-soluble chitosan in this example is purchased from Guangzhou Shengtong Trading Co., Ltd., or can be prepared by itself according to the existing technology. The molecular weight of the chitosan is 1300-1600.

[0035] A preparation method of multidimensional element dispersible tablet:

[0036] The following raw materials were prepared into 1000 pieces;

[0037]

[0038]

[0039]Preparation of granules: Divide the above raw materials into A, B, and C materials, pre-mix A, B, and C materials respectively, and then use a dry granulation machine to obtain granules, then add magnesium stearate to the A, B, and C granules, and polymerize Povidone K30 6g and crospovidone are mixed evenly and granulated;

[0040] The A material is: vitamin A acetate powder, vitamin E powder, vitamin D3, vitamin B2, vitamin B12, vitamin B1, vitamin B6, magnesium oxide, potassium sulfate, man...

Embodiment 2

[0047] Select the WP50N / 75 roller press manufactured by Alexander Company in Germany;

[0048] The water-soluble chitosan in this example is purchased from Guangzhou Shengtong Trading Co., Ltd., or can be prepared by itself according to the existing technology. The molecular weight of the chitosan is 1300-1600.

[0049] A preparation method of multidimensional element dispersible tablet:

[0050] The following raw materials were prepared into 1000 pieces;

[0051]

[0052]

[0053]

[0054] Preparation of granules: Divide the above raw materials into A, B, and C materials, pre-mix A, B, and C materials respectively, and then use a dry granulation machine to obtain granules, then add magnesium stearate to the A, B, and C granules, and polymerize Mix 7.25g of vitamin K30 and crospovidone evenly to make granules;

[0055] The A material is: vitamin A acetate powder, vitamin E powder, vitamin D3, vitamin B2, vitamin B12, vitamin B1, vitamin B6, magnesium oxide, potassiu...

Embodiment 3

[0062] Select the WP50N / 75 roller press manufactured by Alexander Company in Germany;

[0063] The water-soluble chitosan in this example is purchased from Guangzhou Shengtong Trading Co., Ltd., or can be prepared by itself according to the existing technology. The molecular weight of the chitosan is 1300-1600.

[0064] A preparation method of multidimensional element dispersible tablet:

[0065] The following raw materials were prepared into 1000 pieces;

[0066]

[0067]

[0068] Preparation of granules: Divide the above raw materials into A, B, and C materials, pre-mix A, B, and C materials respectively, and then use a dry granulation machine to obtain granules, then add magnesium stearate to the A, B, and C granules, and polymerize Povidone K30 5g and crospovidone were mixed evenly and granulated;

[0069] The A material is: vitamin A acetate powder, vitamin E powder, vitamin D3, vitamin B2, vitamin B12, vitamin B1, vitamin B6, magnesium oxide, potassium sulfate, m...

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Abstract

The invention discloses a multi-vitamin dispersible tablet. Best amounts of auxiliary materials are screened through afresh design of a prescription, and an advanced dry granulation, tabletting and film coated tablet production technology is adopted to main the content of various vitamins unchanged to prepare the domestic advanced dispersible tablet dosage form. Compared with common tablets, the tablet disclosed in the invention can be easily dissolved out and released in vivo, and can be easily absorbed by human body; the dispersion uniformity is increased, so the multi-vitamin dispersible tablet can be dissolved within 3min and passes through a No.2 sieve; and the dissolution rates of vitamin B1, vitamin B2 and nicotinamide in every tablet are preciously determined through adopting high-performance liquid chromatography, are above 98% of labeled amounts, and the qualitative detection disintegration time limit of a common sheet is shorter than 30min, so the quality of the multi-vitamin dispersible tablet is obviously improved. The multi-vitamin dispersible tablet can be cooperatively used in treatment of the stomach cancer, can alleviate symptoms, and enhances the body immunity.

Description

technical field [0001] The invention belongs to the technical field of health care medicines, and in particular relates to a multidimensional element dispersible tablet and a preparation method thereof. Background technique [0002] With the improvement of people's living standards and awareness of health care, as well as changes in people's eating habits and dietary structure, such as excessive intake of fat and refined sugar, insufficient intake of vegetables and fruits, and unbalanced meals, etc. lead to people's intake of A certain nutrient deficiency. A considerable number of people are used to taking some nutritional supplements every day. Nutrient supplements are products made from one or several chemically synthesized or extracted nutrients from natural animals and plants for the purpose of supplementing the nutrients needed by the human body. Multi-element nutritional supplements with the main purpose of supplementing vitamins and trace elements are important vari...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/42A61K9/36A61K47/36A61P35/00A61P37/04A61K31/722A61K31/714A61K31/593A61K31/525A61K31/51A61K31/455A61K31/4415A61K31/375A61K31/047A61K31/198A61K31/355A61K31/222A61K33/08A61K33/32A61K33/04A61K33/30A61K33/18A61K33/34A61K31/197A61K31/194A61K31/205
Inventor 张晓明张聪沈泽龙
Owner ZHEJIANG SHENGBOKANG PHARMA CO LTD
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