Method for extracting glucosamine from self-fermentation liquid

Abstract

The invention discloses a method for extracting glucosamine from a self-fermentation liquid, which comprises the following steps: fermentation liquid flocculation, filtration, double-effect concentration, crude product preparation, fine product preparation and the like. The technique is simple and convenient, and is high in yield.

Description

technical field [0001] The invention relates to a method for extracting glucosamine from fermentation broth. Background technique [0002] Glucosamine is widely used in medicine, chemical industry, food, feed and cosmetic industries. It has important physiological functions for the human body, participates in liver and kidney detoxification, has anti-inflammatory and liver-protecting effects, and can promote the synthesis of mucopolysaccharides in the human body and improve joint synovial fluid. Viscosity, improving the metabolism of articular cartilage, is regarded by the medical community as an important substance that can prevent, alleviate and treat bone and joint diseases, and has the functions of anti-aging, regulating endocrine, lowering blood fat, and lowering blood pressure. It can also be used as a low-calorie sweetener. Flavoring agents are known as the third generation health functional food additives. Glucosamine is usually prepared by hydrolysis of chitin, whi...

AI Technical Summary

Problems solved by technology

[0003] The production of glucosamine by fermentation method includes two-step process of N-acetylglucosamine fermentation and glucosamine extraction. At present, the domestic reports on the method of extracting glucosamine from the fermentation broth include: the fermentation broth is directly separated from the solid and liquid by a ceramic membrane to remove bacteria, The clear liquid is decolorized by activated carbon, desalted by electrodialysis, and concentrated by reverse osmosis to obtain a thick slurry of N-acetylglucosamine. The thick slurry of N-acetylglucosamine is hydrolyzed with hydrochloric acid, decolorized by activated carbon, concentrated in vacuum, cooled and crystallized to obtain the finished product of glucosamine hydrochloride , due to the use of expensive ceramic membrane system, electrodialysis system, reverse osmosis concentration and other equipment, the process requires huge investment

There are also reports of using ion exchange to extract N-acetylglucosamine. This technology requires a large amount of acid and alkali for resin treatment, and the amount of waste water is large, and the yield is still unstable.