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Chitosan and carboxymethyl chitosan functionalized nano selenium compound preparation method

A technology of carboxymethyl chitosan and chitosan, which is applied in the field of preparation of chitosan or carboxymethyl chitosan functionalized nano-selenium complex, can solve the problems of uneven distribution and large particle size of nano-selenium , to achieve narrow particle size distribution, high biological activity, and improved stability

Inactive Publication Date: 2015-08-12
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing literature reports on the compound of nano-selenium polysaccharides are all using polysaccharides to electrostatically adsorb inorganic selenium precursors, and then using a reducing agent to reduce and synthesize nano-selenium. The nano-selenium prepared by this method has a large particle size and uneven distribution.

Method used

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  • Chitosan and carboxymethyl chitosan functionalized nano selenium compound preparation method
  • Chitosan and carboxymethyl chitosan functionalized nano selenium compound preparation method
  • Chitosan and carboxymethyl chitosan functionalized nano selenium compound preparation method

Examples

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Comparison scheme
Effect test

Embodiment 1

[0032] Preparation of nano-selenium sol

[0033] Take 30 milliliters of sodium selenite solution with a concentration of 20 millimoles per liter and 30 milliliters of potassium iodide solution of 30 millimoles per liter and mix them evenly in a 1000 milliliter beaker, then quickly add 30 milliliters of a concentration of 60 millimoles per liter of ascorbic acid solution After 30 minutes of reaction, the stirring was stopped. After the reaction, the solution was orange-red. The above solution was aged at 4°C for 24 hours, and the impurities in the mother liquor were removed by alcohol washing, water washing, and centrifugal washing to obtain purified nano-selenium sol. The structure of nano-selenium was characterized by transmission electron microscope (TEM), high resolution electron microscope (HRTEM), selected area electron diffraction (SAED) and energy spectrum analysis (EDX).

Embodiment 2

[0035] Preparation of chitosan nano selenium

[0036] In the purified nano-selenium sol, 0.08 mg per milliliter of chitosan solution was added dropwise to obtain complexes of chitosan nano-selenium with different concentrations, and chitosan was functionalized by light scattering particle size analysis (DLS). Structural characterization of nanoselenium.

Embodiment 3

[0038] Preparation of Carboxymethyl Chitosan Nano Selenium

[0039] A number of carboxymethyl chitosan solutions of 0.08 mg per milliliter were added dropwise to the purified nano-selenium sol to obtain carboxymethyl chitosan nano-selenium complexes with different concentrations.

[0040] figure 1 The transmission electron microscope (TEM) picture (a) of nano-selenium sol shows that the particle size distribution of nano-selenium is narrow and the particle size is about 50nm. The high-resolution transmission electron microscope (HRTEM) (b) and selective area diffraction (SAED) of a single particle )(C) shows that the nano-selenium is a single crystal selenium structure, and the energy spectrum analysis (EDX) (d) shows that there is no impurity in the nano-selenium structure, which is pure selenium.

[0041] figure 2 The UV-Vis spectrum (UV-Vis) figure shows that Se has an absorption peak at 267nm, and there are no other redundant peaks, indicating that excess ascorbic acid an...

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Abstract

The invention relates to a chitosan and carboxymethyl chitosan functionalized nano selenium compound preparation method, which belongs to the technical field of nano materials. The method is as follows: 1) sodium selenite is used as a selenium source, potassium iodide is used as a stabilizer, the sodium selenite is reacted with reduction agent ascorbic acid for a period of time (30min), and then a nano selenium sol is prepared after standing for ageing for 24 hours; 2) a nano selenium sol is prepared by washing with water, washing with alcohol, and centrifuging for removing impurities; and 3) a certain concentration of chitosan and carboxymethyl chitosan is dropwise added for preparation of a functionalized nano selenium compound. The advantages are that the preparation conditions of nano selenium are simple. The nano selenium nanoparticles are small and uniform, the dispersion is good, a polysaccharide nano selenium compound with opposite charges can be obtained by functionalized modification of the surface by use of the chitosan and carboxymethyl chitosan, and the stability and biocompatibility of the nano selenium can be improved.

Description

technical field [0001] The invention relates to a preparation method of chitosan or carboxymethyl chitosan functionalized nano-selenium complex, which belongs to the technical field of nanometer materials. Background technique [0002] Chitosan has attracted wide attention because of its wide source, wide application, and easy acquisition. It is widely used in food and chemical fields. In addition, chitosan and its derivative carboxymethyl chitosan have Abundant hydroxyl and amino groups are easy to undergo chemical reactions to endow various functions. [0003] With the continuous improvement of people's living standards, the development of high-efficiency, multi-functional compound health care products has become a hot research topic. Selenium is an essential trace element for the human body, known as the "King of Anticancer", and is closely related to the growth, development and occurrence of diseases of humans and other animals. Studies have shown that selenium deficie...

Claims

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Application Information

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IPC IPC(8): A61K33/04A61K47/48A61K47/02A61K47/22A61P3/02A61P35/00
Inventor 乐琳陈琬雯李彦芳杨硕姜启兴
Owner JIANGNAN UNIV
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