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Pharmaceutical composition for preventing and treating myelosuppression and use of pharmaceutical composition

A technology of bone marrow suppression and composition, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of unpreventable use, generation of toxic and side effects, increase of white blood cells, etc., to improve the quality of life, prolong the survival period, increase the effect of quantity

Inactive Publication Date: 2015-08-19
周玉梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Gene recombined hematopoietic growth factors that have just been launched this year, such as leucogen (rhGM-GSF) and whirl blood (rhG-CSF), have a significant effect on increasing white blood cells, but due to the high price, not most patients can afford it. Moreover, rhGM-GSF and rhG-CSF cannot be used at the same time as chemotherapy, nor can they be used for prevention. They can only be used when leukopenia occurs, otherwise there will be toxic side effects
In addition, gene therapy of hematopoietic growth factors such as IL-6, IL-3 and other gene therapy is still in the stage of animal experiments, automyelosuppression is often used in conjunction with high-dose chemotherapy, but it is difficult to apply repeatedly

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The preparation of embodiment 1 Chinese medicine extract

[0016] Weigh 0.36kg of Guazijin and 0.50kg of Chutouhong, wash and remove impurities, dry and pulverize; then add water to the above granular medicinal materials to cover 2cm of the medicinal surface, soak for 1h, remove the medicinal materials, put them in a multi-functional extraction tank and add water for decoction Boil and extract twice, add 16 times the amount of water for the first time, decoct for 2 hours, take the decoction, filter, add 12 times the amount of water for the second time, decoct for 1.5 hours, take two decoctions Combine, filter, heat and concentrate to a thick paste, dry at about 50°C, pulverize, and pass through a 100-mesh sieve to obtain the Chinese medicine extract.

Embodiment 2

[0017] The preparation of embodiment 2 Chinese medicine oral liquid

[0018] Weigh 0.40kg of Guazijin and 0.40kg of Chutouhong, wash and remove impurities, dry and pulverize; then add water to the above granular medicinal materials to cover 2cm of the medicinal surface, soak for 1h, remove the medicinal materials, put them in a multi-functional extraction tank and add water for decoction Boil twice, add 20 times the amount of water for the first time, decoct for 2 hours, take the decoction, filter, add 20 times the amount of water for the second time, decoct for 1 hour, take the two decoctions and combine, Filtrate, heat and concentrate until 1ml of the solution is equivalent to 4g of crude drug, store in a refrigerator at 5°C for 24 hours, and filter the refrigerated solution to obtain the medicinal solution.

Embodiment 3

[0019] Example 3 Experimental study on the prevention and treatment of Chinese medicine extracts on bone marrow suppression caused by chemotherapy in tumor mice

[0020] (1) Replication of tumor model mice: mouse ascites tumor S180 cells were cultured in 1640 medium, 37°C, 5% CO 2 Under conventional culture, subculture once every two days on average, and prepare a density of 3.0×10 with normal saline in the logarithmic growth phase. 7 cells / ml single cell suspension, injected into the peritoneal cavity of mice under aseptic conditions, the abdominal cavity of the mice was obviously swollen 7 days after inoculation, at this time, they were killed by neck dislocation, and soaked in a beaker filled with 75% ethanol After 2-3 minutes, put the sterilized mouse into the ultra-clean workbench, expose the abdomen, extract the ascites with a sterile syringe and put it into a sterile reagent bottle for later use. Count the above ascites with trypan blue, dilute with normal saline, an...

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Abstract

The invention discloses a pharmaceutical composition for preventing and treating myelosuppression and use of the pharmaceutical composition. The pharmaceutical composition is prepared from the following traditional Chinese medicine materials in parts by weight: 29-46 parts of Japanese milkwort herb and 30-60 parts of all-grass of nepal fleshspike. When the pharmaceutical composition is applied to the prevention and control of myelosuppression caused by chemotherapy, the decrease of white blood cells can be prevented, and even the number of central granular cells can be increased, so that the chemotherapy effect of cancers is improved, the lifetime of patients is prolonged, and the life quality is improved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a pharmaceutical composition for preventing and treating myelosuppression caused by chemotherapy and its application. Background technique [0002] The human hematopoietic system is composed of a small number of bone marrow hematopoietic stem cells and different series of hematopoietic cells at different developmental stages. It is very sensitive to various physical, chemical and metabolic harmful factors in the body, such as exposure of the body to radiation or certain chemotherapy drugs, and clinically accepted Patients treated with radiotherapy and chemotherapy are extremely vulnerable to damage and suffer from different degrees of myelosuppression, which manifests as decreased peripheral blood leukocytes, decreased bone marrow proliferation function, and even aplastic anemia, which seriously harms the quality of life of patients and even threat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/69A61P7/00
Inventor 周玉梅
Owner 周玉梅
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