Babesia microti Bm186 antigen and application thereof

A technology of bm186 and Babesia, applied in the field of bioengineering, can solve the problem of low sensitivity of antigens and methods, and achieve the effect of preventing Babesia infection with high specificity and sensitivity
CN104845982AActive Publication Date: 2015-08-19STATION OF VIRUS PREVENTION & CONTROL CHINA DISEASES PREVENTION & CONTROL CENT
2 Cites 1 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
STATION OF VIRUS PREVENTION & CONTROL CHINA DISEASES PREVENTION & CONTROL CENT
Publication Date
2015-08-19

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention provides a separated gene, the sequence of which is as shown in SEQ ID NO: 3. The invention further provides a babesia microti Bm186 antigen protein, which is encoded by the separated gene, and the amino acid sequence of the antigen protein is as shown in SEQ ID NO: 4. The invention further provides an antibody, which specifically combines the babesia microti Bm186 antigen protein. According to expression and purification of the babesia microti Bm186 antigen, a high specificity and sensitivity babesia microti diagnostic method is further established, and the antigen can be applied to different aspects, such as scientific research, and prevention and control of babesia microti; a vaccine provided by the invention has an effect of preventing babesia microti infection. A kit and a colloidal gold immunochromatographic test strip, which are provided by the invention, further can be used for detecting the babesia microti.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the field of bioengineering, and relates to a parasite Babesia vole, specifically Babesia vole Bm186 antigen and application thereof. Background technique

[0002] The first confirmed case of human babesiosis was reported in Yugoslavia in 1957. Subsequently, multiple cases of human babesiosis were reported successively in many European countries and the United States, and a small number of cases also appeared in Japan, mainland China and Taiwan in Asia, South Africa and Egypt in Africa. Babesia is a tick-borne zoonotic disease caused by Babesia parasitic on the red blood cells of vertebrates. At present, the Babesia that can cause human babesiosis have been identified, including a few species of Babesia (Babesiidae) such as Babesia microti and Babesia divergens. .

[0003] Humans are usually infected through the bites of carrying ticks or clinical transfusion of blood donated by asymptomatic infected persons. The clinical s...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More