Synthesis process of hydroxybenzene ether (III)

Abstract

The invention discloses a synthesis process of hydroxybenzene ether (III). According to the synthesis process, hydroxybenzene ether of which the content is 99% or above can be successfully obtained through two reaction steps (etherification and oxidation) in a micro-channel mode, and in the micro-channel reaction process, because of a small amount of instantaneous reaction substances, industrial potential safety hazard caused by use of dangerous reagents can be effectively reduced. In addition, compared with an ordinary kettle reaction, the synthesis process is low in use amounts of an alkylation agent and a catalyst in the micro-channel reaction process, high in reaction selectivity, few in side reactions, high in product purity, simple in aftertreatment, small in wastewater amount, simple in wastewater component, and convenient in treatment, and the process wastewater amount can be greatly reduced; the reaction solvent can be repeatedly used, waste liquid generated can be reduced, and the process cost can be lowered; sodium sulfate generated through oxidation reaction is stable in quality and can be used in industrial products such as a cement water reducing agent, and both the solid waste can be reduced and the process cost is reduced, so that industrialization can be easily achieved, the operation is simple, the industrial security degree is high, and the environment-friendly requirements can be met.

Description

technical field [0001] The invention relates to a preparation method of organic compounds, in particular to a synthesis process of hydroxyphenyl ether (III). Background technique [0002] Hydroxyphenyl ether (III), such as o-hydroxyanisole, o-hydroxyphenethyl ether, etc., is a class of important pharmaceutical and spice intermediates. Among them, o-hydroxyanisole, also known as guaiacol, has a special sweet smell and can be used directly as a fragrance, or as an intermediate for synthetic fragrances (such as vanillin), and various anti-inflammatory and antibacterial drugs . In recent years, guaiacol has made great breakthroughs in the research and application of high-end products in the fragrance industry, and the application market has gained a huge room for expansion. [0003] The earliest process for synthesizing guaiacol is the diazotization method of o-aminoanisole. The general process of this method is to synthesize o-nitroanisole through substitution reaction of o-n...

AI Technical Summary

Problems solved by technology

In recent years, some domestic manufacturers have used catechol and methylene chloride as raw materials to produce guaiacol through selective methylation with the assistance of special catalysts, and at the same time produce some dimethylated by-products. Although the waste water of this process is less than that of the diazotization method of anthranil, the utilization rate of methyl chloride is low under the condition of tank reaction, and the amount of methyl chloride is greatly excessive during the reaction process. In order to prevent the leakage of highly toxic methyl chloride, The reaction needs to be carried out under certain pressure conditions, and the excess monochloromethane needs to be specially treated at the end of the reaction

Therefore, the above two kinds of techniques for producing guaiacol have long production cycle, low conversion rate, poor reaction selectivity, low product yield, poor quality (containing chloride ions), and serious environmental pollution.

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