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Synthesis method of pharmaceutical-grade potassium antimony tartrate

A technology of antimony potassium tartrate and a synthesis method, which is applied in the direction of antimony organic compounds, can solve the problems of low antimony recovery utilization rate, unstable product quality, complicated production process, etc., and achieve easy control of the reaction process, stable product quality, and reduced The effect of production costs

Inactive Publication Date: 2015-09-09
TIANJIN VOCATIONAL INST
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Problems solved by technology

The production of high-purity pharmaceutical-grade antimony potassium tartrate products must be refined through filtration, impurity removal, and recrystallization. The production process is complicated, the production cycle is long, the recovery rate of antimony is not high, and the product quality is not stable enough.

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0023] Add high-purity industrial antimony trioxide (Sb 2 o 3 ) 146.5g (0.5mol) and 31% concentrated hydrochloric acid 353.2g (3.0mol), heated to reflux for 1-2 hours to dissolve antimony trioxide in excess hydrochloric acid to generate antimony trichloride solution; after cooling, filter and separate trichloride Insoluble impurities in the antimony solution; heat and concentrate the filtered antimony trichloride solution in a glass evaporator, and evaporate and recover excess hydrochloric acid at the same time; cool the antimony trichloride concentrated solution to room temperature, crystallize under stirring, and vacuum filter to separate the three Antimony chloride crystallization; dissolve the antimony trichloride filter cake in 100ml deionized water, add 374g (3.3mol) of 15% ammonia water under stirring to hydrolyze, and generate white antimony acid sol; filter and separate the antimony acid sol Wash the filter cake until there is almost no chloride ion in the washing wa...

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Abstract

The invention discloses a synthesis method of pharmaceutical-grade potassium antimony tartrate. Newly prepared metantimonic acid sol is used instead of insoluble antimony trioxide to perform liquid-phase reaction with potassium bitartrate in a water solution to prepare the high-purity potassium antimony tartrate. The method comprises the following steps: dispersing metantimonic acid sol in deionized water, adding ground potassium bitartrate crystal, heating and stirring for 0.5-1 hour to form a potassium antimony tartrate solution, carrying out vacuum concentration at 70-80 DEG C until a crystal precipitates, regulating the pH value of the solution to 5-7 with a potassium bitartrate solution, cooling to room temperature, precipitating the crystal, washing with anhydrous ethanol, and drying to obtain the high-purity white crystal product with the purity of 99.5%.

Description

technical field [0001] The invention relates to a synthesis method of medical-grade potassium antimony tartrate, in particular to a method for preparing high-purity potassium antimony tartrate by reacting newly prepared antimony acid and potassium hydrogen tartrate, belonging to the fine chemical industry field. Background technique [0002] Potassium antimony tartrate is colorless transparent needle-like crystal or white crystalline powder, loses water of crystallization at 100 °C, insoluble in ethanol, soluble in water or glycerin. The solubility in water is 8.3g at 25°C and 35.9g at 100°C. Clinically, it is often used as an insecticide. Oral and intravenous injection of antimony potassium tartrate preparations can treat schistosomiasis, schistosomiasis, leishmaniasis, trypanosomiasis, etc. In recent years, studies have found that antimony potassium tartrate has certain anticancer activity, and As 2 o 3 It can also significantly inhibit the growth of leukemia cells and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F9/90
Inventor 李建生李无为刘建光
Owner TIANJIN VOCATIONAL INST
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