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A kind of enteric-coated preparation of breviscapine extract

A technology of Dengzhan Xixin and enteric-coated preparations, which is applied in the field of pharmaceutical preparations, and achieves the effects that the preparation method is simple and feasible, the preparation method is simple, and the preparation process is easy to control.

Active Publication Date: 2018-07-24
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to ensure a good curative effect while reducing adverse reactions and facilitate long-term use, it may be considered to develop Erigeron breviscapus enteric-coated preparations, but there are no related patents and literature reports yet

Method used

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  • A kind of enteric-coated preparation of breviscapine extract
  • A kind of enteric-coated preparation of breviscapine extract
  • A kind of enteric-coated preparation of breviscapine extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: the preparation of enteric solid dispersion

[0023] Erigeron Asarum Extract 5g

[0024] Cellulose acetate phthalate 15g

[0025] Crospovidone 10g

[0026] (1) The preparation method of Erigeron breviscapus extract is as follows: crush the dried scutellaria scutellaria medicinal material, pass through a 20-mesh sieve, add 10 times the mass percentage of the medicinal material to the crushed medicinal material, and add a 60% ethanol solution, and reflux extraction twice , 30min each time, combine the extracts, concentrate under reduced pressure to recover the solvent, dilute the concentrated solution with water, filter, apply HPD-100 macroporous adsorption resin to the filtrate, wash it with water until it is colorless, and use ethanol with a mass percentage concentration of 90% Solution elution, the volume of the eluent is 10 times the column volume; the eluent is concentrated, the pH value is adjusted to 6.5, and then spray-dried to obtain the brown-yel...

Embodiment 2

[0028] Embodiment 2: Preparation of enteric solid dispersion

[0029] Erigeron Asarum Extract 5g

[0030] Eudragit L100 (carrier) 10g

[0031] Hypromellose 1.5g

[0032] (1) The preparation method of Erigeron breviscapus extract is as follows: crush the dried scutellaria breviscapine medicinal material, pass through a 16-mesh sieve, add 60% ethanol solution with a concentration of 15 times the mass percentage of the medicinal material to the crushed medicinal material, and reflux extraction for 3 times , 30min each time, combine the extracts, concentrate under reduced pressure to recover the solvent, dilute the concentrate with water, filter, apply the HPD-100 macroporous adsorption resin to the filtrate, wash it with water until it is colorless, and use ethanol with a mass percentage concentration of 50% Solution elution, the eluent volume is 15 times the column volume; the eluent is concentrated, the pH value is adjusted to 6.5, and then spray-dried to obtain the brown-yel...

Embodiment 3

[0034] Embodiment 3: Preparation of enteric-coated capsules

[0035] Erigeron Asarum Extract 5g

[0036] β-cyclodextrin 7.5g

[0037] Sodium carboxymethyl starch 1.5g

[0038] Polyacrylic resin L100-55 15g

[0039] Microcrystalline Cellulose 50g

[0040](1) The preparation method of Erigeron breviscapus extract is as follows: crush the dried scutellaria breviscapine medicinal material, pass through a 18-mesh sieve, add 60% ethanol solution with a concentration of 12 times the mass of the medicinal material to the crushed medicinal material, and reflux extraction for 3 times , 30min each time, combine the extracts, concentrate under reduced pressure to recover the solvent, dilute the concentrate with water, filter, apply HPD-100 macroporous adsorption resin on the filtrate, wash it with water until it is colorless, and use ethanol with a mass percentage concentration of 35% Solution elution, the eluent volume is 5 times the column volume; the eluent is concentrated, the pH ...

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Abstract

The invention discloses an enteric-coated preparation of radix radix radix extract. The enteric-coated preparation is made from the extract of radix radix radix and pharmaceutical excipients for the enteric-coated preparation. 2 to 19 parts of excipients; taking ethanol extract of Asarum brevis as raw material, adding excipients and then preparing enteric-coated preparations of Asarum brevis through enteric preparation technology; experimental results show that the dissolution rate of the enteric preparations in artificial gastric juice is low At 5%, it is disintegrated and released in artificial intestinal juice; the preparation of the present invention can effectively avoid the stimulation of the phenolic acid components in Dengzhan Asarum to gastric mucosa, and the process is simple and suitable for industrial production.

Description

technical field [0001] The invention relates to a new dosage form of traditional Chinese medicine, in particular to an enteric-coated preparation of oral breviscapine extract, which belongs to the field of pharmaceutical preparations. Background technique [0002] Dengzhan Xixin was first recorded in "Southern Yunnan Materia Medica". Erigeron breviscapas vant Hand Mass) whole herb, also known as breviscapus, has the functions of dispelling cold and relieving the exterior, expelling wind and dampness, promoting blood circulation and removing blood stasis, dredging collaterals and relieving pain, and improving microcirculation. It is widely used clinically to treat hypertension, cerebral hemorrhage, coronary heart disease, For diseases such as angina pectoris, the market economy has broad prospects, and its medicinal value is also being continuously developed. Now Erigeron breviscapus extract has not only become a cardiovascular and cerebrovascular medicine with good curat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/22A61K36/28A61K9/48A61K9/20A61K9/16A61K9/00A61P9/12A61P9/10A61P7/04
Inventor 向诚孔靓李宝才黄财顺
Owner KUNMING UNIV OF SCI & TECH