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Application of matteuccia struthiopteris total triterpenes to protection of chronic alcoholic liver damage

A technology for alcoholic liver injury and total triterpenes, which is applied in the field of biomedicine, can solve the problems of less research on chemical constituents, pharmacology and mechanism of Pteridophos vulgaris, and achieves considerable development and application value and no toxic and side effects.

Active Publication Date: 2015-09-23
SHAANXI NORMAL UNIV
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  • Abstract
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Problems solved by technology

Up to now, there are few studies on the chemical constituents of Viburnum viburnum and their pharmacology and mechanism

Method used

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  • Application of matteuccia struthiopteris total triterpenes to protection of chronic alcoholic liver damage
  • Application of matteuccia struthiopteris total triterpenes to protection of chronic alcoholic liver damage
  • Application of matteuccia struthiopteris total triterpenes to protection of chronic alcoholic liver damage

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Embodiment Construction

[0023] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0024] 1. Experimental materials

[0025] The pod fern was collected from Xunyangba Town, Ningshan County, Shaanxi Province. It was identified as Matteuccia struthiopteris (Matteuccia struthiopteris) of the genus Matteuccia Todaro in the Onocleaceae family (Onocleaceae) by Associate Professor Ma Ji, School of Life Sciences, Shaanxi Normal University; male Kunming species 70 mice (body weight 18±2g) were provided by the Animal Experiment Center of Fourth Military Medical University.

[0026] Experimental reagents: absolute ethanol, xylene, sodium chloride, and hydrochloric acid were purchased from Tianjin Tianli Chemical Reagent Co., Ltd.; paraformaldehyde, hematoxylin, sectioned paraffin, bifendate, neutral gum, and eosin were purchased from Beijing Chemical Reagent Company; medical alanine ...

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Abstract

The invention discloses application of matteuccia struthiopteris total triterpenes to protection of chronic alcoholic liver damage and belongs to the technical field of biomedicine. Modeling is performed by adopting a dose incremental drinking method, and a chronic liver damage process induced by alcohol of human is simulated. Matteuccia struthiopteris total triterpenes can inhibit GOT and GPT to a certain extent, and an inhibition action is in direct proportion to dosage of administration. Purified matteuccia struthiopteris total triterpenes has higher in-vivo anti-oxidation capability, and a live protection mechanism is that the damage of alcohol to the liver is effectively relieved by enhancing the anti-oxidation capability of the body and effectively removing harmful free radicals. In the purified matteuccia struthiopteris total triterpenes, high dose can effectively relieve oxidated damage caused by factors such as lipid peroxidation in the liver and attack of the free radicals, degree of liver cell enlargement, necrosis and fatty degeneration is reduced, normal metabolism and physiological functions of the cells are regulated, and the effect thereof is superior to that of positive control medicine bifendate in a certain range, which shows that matteuccia struthiopteris total triterpenes has a certain protection action against chronic alcoholic liver damage.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of total triterpenoids of Pteridocarpus to protect chronic alcoholic liver injury. Background technique [0002] At present, liver disease has become one of the diseases that generally plague human health all over the world. Liver injury refers to the invasion of the liver by external factors, resulting in damage to its structure and function. According to the different causes of liver damage, it can be roughly divided into three types: drug-induced hepatitis, alcoholic hepatitis and viral hepatitis. [0003] Alcoholic Liver Disease (ALD) refers to a series of diseases such as liver damage caused by excessive intake of alcohol. The Liver Branch of the Chinese Medical Association has established pathological diagnostic criteria for ALD based on the degree of lesions, and is generally divided into five types according to histology: mild alcoholic l...

Claims

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Application Information

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IPC IPC(8): A61K36/11A61P1/16A61P37/00A61P39/06A23L1/29
Inventor 马骥杨晓艳张贵凤
Owner SHAANXI NORMAL UNIV
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