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Pharmaceutical composition for treating helicobacter pylori infectious gastropathy and preparation method of pharmaceutical composition

A technology of Helicobacter pylori and its composition, applied in the field of pharmaceutical preparations, can solve the problems of dependence and side effects, induce gastrointestinal diseases, treat the symptoms but not the root cause, etc., and achieve the effect of no toxic side effects, short treatment period and definite curative effect

Inactive Publication Date: 2015-10-07
吴强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

4. Helicobacter pylori infection generally has no obvious symptoms sometimes. At this time, it is generally checked to determine whether there is Helicobacter pylori infection. Helicobacter pylori is a pathogenic bacterium that can easily induce gastrointestinal diseases.
[0011] But above-mentioned method of treatment: treat the symptoms but not the disease, be unfavorable for treatment, and commonly used have dependence and side effect big

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0066] When the dosage form of the pharmaceutical composition is a granule, its preparation method comprises the following steps:

[0067] The first step is to mix the raw materials of the pharmaceutical composition according to the stated ratio, add ethanol with an alcohol concentration of 85% to 95% that is 4 to 8 times that of the mixture, heat to boiling and reflux for 3 to 5 hours, and filter. Use the percolation method to percolate slowly at a rate of 1-2ml per minute, collect the percolation liquid, and then concentrate under reduced pressure at a vacuum of 0.06-0.09Mpa to a paste with a relative density of 1.04-1.10 at 50-60°C. Spray drying, the air inlet temperature of the spray dryer is 160-175°C, the outlet air temperature is 80-85°C, and then crushed into powder to make dry paste powder;

[0068] In the second step, 0.2-0.4 times of sucrose powder and 0.1-0.2 times of dextrin are added to the obtained dry paste powder to form granules, and dried at 40-50° C. to obt...

Embodiment 1

[0077] Example 1 Granules

[0078] The preparation process of the granules of the present invention is as follows: get 200g of Andrographis paniculata, 150g of Qianlingdan, 220g of Tinglizizi, 120g of Hovenia dulcis, 180g of Paicaoxiang, 140g of Stachys root, 200g of Polygonum japonica, 160g of Daquan hemp, and 300g of Baiji , Weihancao 320g, Smilax 240g, Jinbuhuan 130g, Sarsaparilla vine 280g, Coix seed 160g, Pteris 300g, Scutellaria barbata 220g, Apostichopus japonicus 150g, Cardamom 360g, Huoxiang 240g, Capillary wormwood 160g, Talc 230g , Shichangpu 300g, Scutellaria baicalensis 120g, Forsythia 260g, Shegan 340g, Desmodium 330g, Yuanhu 170g, Northern Radix Ginseng 260g and Black Gardenia 220g;

[0079] The first step is to mix the raw materials of the pharmaceutical composition according to the stated ratio, add ethanol with an alcohol concentration of 90% that is 5 times that of the mixture, heat to boiling and reflux for 4 hours, filter, and use the percolation method at...

Embodiment 2

[0081] Example 2 Capsules

[0082]The manufacture process of the capsule of the present invention is: get Andrographis paniculata 320g, Qianlingdan 200g, Tinglizi 180g, Hovenia dulcis 160g, Paicaoxiang 220g, Stachys root 120g, Polygonum japonica 250g, Daquan hemp 200g, Baihe 400g , Weihancao 310g, Smilax 270g, Jin Bu Huan 160g, Sage vine 330g, Coix seed 160g, Pteris 260g, Scutellaria barbata 240g, Sea cucumber 140g, Cardamom 360g, Huoxiang 300g, Capillary wormwood 160g, Talc 320g , Shichangpu 240g, Scutellaria baicalensis 150g, Forsythia 160g, Shegan 330g, Desmodium 350g, Yuanhu 180g, Northern Radix Ginseng 320g and Black Gardenia 200g;

[0083] The first step is to mix the raw materials of the pharmaceutical composition in proportion, add ethanol with an alcohol concentration of 95% that is 3 times the mass of the mixture, heat and reflux for 2 hours, extract, and filter to obtain the first extract; Then add ethanol with an alcohol concentration of 85% to the dregs of the dr...

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Abstract

The invention discloses a pharmaceutical composition for treating helicobacter pylori infectious gastropathy and a preparation method of the pharmaceutical composition. The pharmaceutical composition comprises the following medicinal materials: common andrographis herb, rhaphidophora hongkongensis, semen lepidii, hovenia dulcis thumb, hairystalk loosestrife herb, baikal betony rhizome, polygonum dissitiflorum, palmate girardinia herb, rhizoma bletillae, peucedanum morisonii bess, chinaroot greenbrier, stephania sinica diels, wild grape vine, semen coicis, phoenix-tail fern, sculellaria barbata, stichopus japonicus, alpinia katsumadai, agastache rugosus, oriental wormwood, talcum, rhizoma acori graminei, scutellaria baicalensis, fructus forsythiae, blackberry lily, lysimachia christinae hance, rhizoma corydalis, radix glehniae and black jasmine. The pharmaceutical composition has the beneficial effects that the pharmaceutical composition has the efficacy of clearing away heat and toxic materials, has the effects of reinforcing the stomach, protecting a membrane, dredging qi movement, clearing away fire and benefiting qi, is mainly used for treating helicobacter pylori infectious gastropathy, is suitable for long-term recuperation, is free of an effect on appetite and beneficial to recovery of the organism, and has the advantages of fast acting, high effective rate, accurate curative effect, short treatment course, no toxic or side effect and low price; and cold and heat are taken into account.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition for treating Helicobacter pylori infectious gastropathy and a preparation method thereof. Background technique [0002] Helicobacter pylori (HP) is a spiral-shaped Gram-negative bacterium in the human gastric mucosa. The cells of Helicobacter pylori are smooth and S-shaped, with 4-6 flagella. It is easy to adhere to the mucosa of the gastric antrum and gastric body near the pylorus, located in the deep layer of gastric mucus, and does not directly contact with gastric acid. Helicobacter pylori is transmitted from person to person through the oral route, and viable Helicobacter pylori can survive in river water for 1 week. Helicobacter pylori can produce a variety of enzymes such as urease, peroxidase, protease, phospholipids and so on. Among them, urease can decompose urea to produce ammonia, which not only protects bacteria f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9062A61P1/00A61P31/04A61K33/12
Inventor 吴强
Owner 吴强
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