Polyethylene glycol-modified vitamin E liposome and its preparation method and use

A polyethylene glycol and vitamin technology, applied in the field of daily care products, can solve problems such as insecurity, and achieve the effects of being beneficial to use, improving stability and improving encapsulation rate

Active Publication Date: 2015-11-18
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above methods all need to use a certain amount of emulsifier Tween 80 in order to ensure the stability of liposomes, and becaus

Method used

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  • Polyethylene glycol-modified vitamin E liposome and its preparation method and use
  • Polyethylene glycol-modified vitamin E liposome and its preparation method and use
  • Polyethylene glycol-modified vitamin E liposome and its preparation method and use

Examples

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Example Embodiment

[0039] Example 1

[0040] A preparation method of polyethylene glycol-modified vitamin E liposomes, comprising the following preparation steps:

[0041] (1) Weigh 0.08g of egg yolk lecithin, 0.08g of cholesterol, 0.04g of vitamin E and 0.4g of sodium cholate into a conical flask, add 20ml of a mixed solvent of chloroform and methanol with a volume ratio of 1:1, and stir to dissolve Obtain a mixed solution evenly;

[0042] (2) The mixed solution is placed in a rotary evaporator, and the solvent is removed by rotating vacuum in a constant temperature water bath at 42° C. to obtain a liposome film attached to the wall of the device;

[0043] (3) 0.4g polyethylene glycol is dissolved with the phosphate buffer solution of pH7.4, and preparation mass concentration is the polyethylene glycol solution of 1%, then joins in the rotary evaporator of step (2), in 40 ℃ of water baths Rotate hydration for 1 hour under the condition to obtain orange liposome suspension;

[0044] (4) Ultra...

Example Embodiment

[0048] Example 2

[0049] A preparation method of polyethylene glycol-modified vitamin E liposomes, comprising the following preparation steps:

[0050] (1) Weigh 0.08g of soybean lecithin, 0.08g of cholesterol, 0.04g of vitamin E and 0.8g of sodium cholate into a conical flask, add 20ml of a mixed solvent of chloroform and methanol with a volume ratio of 1:1, and stir to dissolve Obtain a mixed solution evenly;

[0051] (2) The mixed solution is placed in a rotary evaporator, and the solvent is removed by rotating vacuum in a constant temperature water bath at 60° C. to obtain a liposome film attached to the wall of the device;

[0052] (3) 0.4g polyethylene glycol is dissolved with the phosphate buffer solution of pH7.4, and preparation mass concentration is the polyethylene glycol solution of 10%, then joins in the rotary evaporator of step (2), in 60 ℃ of water baths Rotate hydration for 1 hour under the condition to obtain orange liposome suspension;

[0053] (4) Ultra...

Example Embodiment

[0056] Example 3

[0057] A preparation method of polyethylene glycol-modified vitamin E liposomes, comprising the following preparation steps:

[0058] (1) Weigh 0.08g of egg yolk lecithin, 0.08g of cholesterol, 0.04g of vitamin E and 1.0g of sodium cholate into a conical flask, add 20ml of a mixed solvent of chloroform and methanol with a volume ratio of 1:1, and stir to dissolve Obtain a mixed solution evenly;

[0059] (2) The mixed solution is placed in a rotary evaporator, and the solvent is removed by rotating vacuum in a constant temperature water bath at 80° C. to obtain a liposome film attached to the wall of the device;

[0060] (3) 0.8g polyethylene glycol is dissolved with the phosphate buffer solution of pH7.4, and preparation mass concentration is the polyethylene glycol solution of 20%, then joins in the rotary evaporator of step (2), in 60 ℃ of water baths Rotate hydration for 1 hour under the condition to obtain orange liposome suspension;

[0061] (4) Ultr...

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Abstract

The invention belongs to the technical field of daily use care products and discloses polyethylene glycol-modified vitamin E liposome and its preparation method and use. The polyethylene glycol-modified vitamin E liposome comprises 10-100 parts of phosphatidylcholine, 10-100 parts of cholesterol, 10-150 parts of vitamin E, 200-600 parts of sodium cholate, 1000-4000 parts of polyethylene glycol and 400-800 parts of a freeze drying protective agent. The preparation method comprises dissolving phosphatidylcholine, cholesterol, vitamin E and sodium cholate in a mixed solvent of chloroform and methanol, removing the solvent so that a liposome film is obtained, adding the liposome film into a polyethylene glycol solution to obtain a liposome suspension, carrying out ultrasonic dispersion and dialysis on the liposome suspension, adding the freeze drying protective agent into the solution obtained by dialysis, and carrying out freeze drying to obtain the polyethylene glycol-modified vitamin E liposome. The polyethylene glycol-modified vitamin E liposome has good stability and skin permeability, can be used for a skin care product and has effects of removing oxyradical and delaying ageing.

Description

technical field [0001] The invention belongs to the technical field of daily care products, and in particular relates to a polyethylene glycol-modified vitamin E liposome and a preparation method and application thereof. Background technique [0002] With the acceleration of urbanization, air pollution is becoming more and more serious, and the pressure of life is also increasing. The generation and accumulation of oxygen free radicals in people's daily life are becoming more and more serious, which leads to the aggravation of skin aging and the occurrence of skin diseases. The probability is also increasing. A good skin care product has been developed that is both cost-effective and highly effective in eliminating oxygen free radicals. [0003] Vitamin E has a good cosmetic effect. First of all, the side chain double bond of vitamin E can directly participate in the oxidation-reduction process of sulfhydryl groups, inhibit the activity of tyrosinase, and prevent pigmentat...

Claims

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Application Information

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IPC IPC(8): A61K8/67A61K8/84A61K8/14A61Q19/08
Inventor 曹晓东张禹胡光豫吴焯然赵欣陈钰蓝黄岳山肖斯宇
Owner SOUTH CHINA UNIV OF TECH
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