Niacin zantino injection composition, nicotin zantino freeze-dried powder injection and preparation method thereof
A technology of niacin, zantino, and freeze-dried powder injection, which is applied in freeze-dried delivery, drug combination, active ingredients of heterocyclic compounds, etc., can solve problems affecting drug safety, many uncontrollable factors, and high impurity content, etc. Achieve the effects of easy storage and market sales, good stability, and reduced production costs
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Embodiment 1
[0028] Prescription composition (specification: 0.6g) 1000 bottles:
[0029]
[0030] Preparation:
[0031] Weigh 80% of the total amount of water for injection and add it to the liquid preparation tank, add hydroxypropyl-β-cyclodextrin and mannitol to dissolve it, pass cooling water into the interlayer and cool it to 18°C, weigh niacin and add it to it, Stir to dissolve, add water for injection (cooled to 18°C with another liquid mixing tank) to the full amount, adjust the pH value to 6.1-6.5 with 1mol / L sodium hydroxide solution; add activated carbon of 0.1% of the total amount of the prepared drug solution, Stirring for 30 minutes, coarse filtration and 0.22 μm microporous membrane sterilization filtration, the obtained semi-finished stock solution was divided into vials, half-covered with rubber stoppers, and freeze-dried.
[0032] The freeze-drying process is as follows: Put the divided semi-finished product stock solution into the freeze-drying box, keep the temper...
Embodiment 2
[0034] Prescription composition (specification: 0.6g) 1000 bottles:
[0035]
[0036] Preparation:
[0037] Weigh 80% of the total amount of water for injection and add it to the liquid preparation tank, add hydroxypropyl-β-cyclodextrin and mannitol to dissolve it, pass cooling water into the interlayer and cool it to 18°C, weigh niacin and add it to it, Stir to dissolve, add water for injection (cooled to 18°C with another liquid mixing tank) to the full amount, adjust the pH value to 6.1-6.5 with 1mol / L sodium hydroxide solution; add activated carbon of 0.1% of the total amount of the prepared drug solution, Stirring for 30 minutes, coarse filtration and 0.22 μm microporous membrane sterilization filtration, the obtained semi-finished stock solution was divided into vials, half-covered with rubber stoppers, and freeze-dried.
[0038] Put the divided semi-finished product stock solution into the freeze-drying box, keep the temperature at -30°C for 3 hours; evacuate to l...
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