Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Mesoporous organosilica nanosphere adopting double-layer yolk-eggshell structure and preparation method

An organic silicon oxide and nanosphere technology, which is applied in the field of nanomaterials to achieve the effects of regular morphology, good dispersion and biocompatibility, and uniform size

Active Publication Date: 2015-11-18
NANJING UNIV OF POSTS & TELECOMM
View PDF3 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the synthesis of organosilica with a double-layer egg yolk-eggshell structure with different organic groups in the inner and outer layers has not yet been reported in articles or published in patents.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Mesoporous organosilica nanosphere adopting double-layer yolk-eggshell structure and preparation method
  • Mesoporous organosilica nanosphere adopting double-layer yolk-eggshell structure and preparation method
  • Mesoporous organosilica nanosphere adopting double-layer yolk-eggshell structure and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) Dissolve 0.08g of surfactant in a mixed solution containing 1ml of ammonia, 30ml of ethanol and 75ml of water, mix 0.25ml of tetraethylorthosilicate and 0.1ml of bis[γ- (Triethoxysilyl) propyl] tetrasulfide mixture is added to the above-mentioned mixed solution, reacted for 24h, the tetraethylorthosilicate, surfactant, bis[γ-(triethoxysilyl ) Propyl] tetrasulfide, ethanol and water molar ratio 1:0.1:0.18:461:3728, of which NH contained in ammonia 3 The mass percentage is 26%.

[0035] (2) Centrifuge the mixture of step (1), wash with alcohol, and transfer it to a mixed solution of 1ml ammonia, 29ml ethanol and 70ml water, add 0.1g surfactant, 0.125ml tetraethylorthosilicate, 0.1ml 1.2 -Bis(triethoxysilyl)ethane, reacted for 24h at 35°C and 1100rpm stirring conditions, the tetraethylorthosilicate, 1.2-bis(triethoxysilyl)ethane, surface The molar ratio of active agent, water and ethanol is 1:0.5:0.5:7000:900, of which NH contained in ammonia 3 The mass percentage is 26%...

Embodiment 2

[0040] (1) Dissolve 0.16g surfactant in a mixed solution containing 1ml ammonia, 30ml ethanol and 75ml water, and mix 0.25ml tetraethyl orthosilicate and 0.1ml bis[γ- (Triethoxysilyl) propyl] tetrasulfide mixture is added to the above-mentioned mixed solution and reacted for 24h. The tetraethylorthosilicate, surfactant, bis[γ-(triethoxysilyl) ) Propyl] tetrasulfide, ethanol and water molar ratio is 1:0.4:0.18:461:3728, which contains NH in ammonia 3 The mass percentage is 26%.

[0041] (2) Centrifuge the mixture of step (1), wash with alcohol, and transfer it to a mixed solution containing 1ml ammonia, 30ml ethanol and 75ml water, add 0.16g of surfactant, 0.125ml of tetraethylorthosilicate and 0.12 ml of 1.2-bis(triethoxysilyl)ethane was reacted for 12h at 35°C and 1200rpm stirring conditions. The tetraethylorthosilicate and 1.2-bis(triethoxysilyl)ethane The molar ratio of alkane, surfactant, water and ethanol is 1:0.6:0.8:7455:921, among which NH contained in ammonia 3 The mass...

Embodiment 3

[0046] (1) Dissolve 0.2g surfactant in a mixed solution of 1ml ammonia, 30ml ethanol and 75ml water, mix 0.25ml tetraethylorthosilicate and 0.1ml bis[γ-( Triethoxysilyl) propyl] tetrasulfide mixture is added to the above-mentioned mixed solution, reacted for 3h, the tetraethylorthosilicate, surfactant, bis[γ-(triethoxysilyl) The molar ratio of propyl]tetrasulfide, ethanol and water is 1:0.5:0.18:461:3728. NH contained in ammonia 3 The mass percentage is 26%.

[0047] (2) Centrifuge the mixture of step (1), wash with alcohol, and transfer it to a mixed solution of 1ml ammonia, 32ml ethanol and 90ml water, add 0.18g surfactant, 0.125ml tetraethylorthosilicate and 0.14ml The 1.2-bis(triethoxysilyl)ethane was reacted for 3h at 35°C and 500rpm stirring. The tetraethylorthosilicate and 1.2-bis(triethoxysilyl)ethane The molar ratio of surfactant, water and ethanol is 1:0.7:0.9:9000:1000, and the ammonia contains NH 3 The mass percentage is 26%.

[0048] (3) Centrifuge the product obtai...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Outer diameteraaaaaaaaaa
Outer diameteraaaaaaaaaa
Apertureaaaaaaaaaa
Login to View More

Abstract

The invention discloses a mesoporous organosilica nanosphere adopting a double-layer yolk-eggshell structure and a preparation method. The mesoporous organosilica nanosphere is a spherical body with an inner-layer hollow structure and an outer-layer hollow structure, wherein the inner layer contains a thioether bond, the outer layer contains an ethane group, and mesoporous channels are formed in the inner layer and the outer layer. Two kinds of organosilicone sources are adopted, organosilane bis(gamma-(triethoxysilyl) propyl) tetrasulfide containing the thioether bond (-(CH3)3-S4-(CH3)3-) and organosilane 1.2-bis(triethoxysilyl) ethane containing the ethane group (-CH2-CH2-) are added to a reaction solution sequentially, and synthesized organosilica has good hydrothermal stability and chemical activity with introduction of the two kinds of organosilicone sources; the mesoporous organosilica nanosphere has a regular shape and uniform size, agglomeration of particles is avoided, a large cavity is formed between the inner layer and the outer layer, and the mesoporous organosilica nanosphere has excellent dispersibility and biocompatibility and has huge application potential in the aspects of catalysis, drug delivery and the like.

Description

Technical field [0001] The invention relates to a mesoporous organic silica nanosphere with a double-layer egg yolk-egg shell structure and a preparation method thereof, belonging to the field of nano materials. Background technique [0002] Mesoporous silica nanomaterials are one of the most promising carriers in the fields of drug and gene delivery. Organosilica nanomaterials prepared by using bridged organosilanes as precursors have the properties of both organic and inorganic materials, which can control the drug release rate and realize the biodegradability of drug carriers, which has become a research hotspot in the field of drug carrier materials. However, the preparation of mesoporous organosilicon oxides with various organic groups and hollow structures still faces great challenges. [0003] The mesoporous silica material with egg yolk-egg shell structure has good biocompatibility, high specific surface area, uniform pore size and large cavity, and shows great application...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): B01J13/02B01J20/22B01J20/30B01J31/02B01J35/10B82Y40/00B82Y30/00
Inventor 汪联辉张俊杰翁丽星滕兆刚
Owner NANJING UNIV OF POSTS & TELECOMM
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com