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Preparation method of aloe/sodium alginate double-layer hydrogel dressing

A sodium alginate and hydrogel technology, used in medical science, bandages, absorbent pads, etc., can solve problems such as exogenous infection, affect wound healing, damage new tissue, etc., achieve excellent antibacterial properties, and promote fibroblasts. Proliferation and proliferation-promoting effect

Inactive Publication Date: 2015-11-25
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, absorbent cotton, gauze, and bandages are commonly used dry dressings in hospitals to treat wounds, which have played a certain role in early wound healing, but there are still many shortcomings: such as dry dressings have poor air permeability, and can easily lead to exogenous infections when soaked ; Can not maintain the moisture of the wound, delay the healing of the wound; cause foreign body reaction, seriously affect the healing of the wound; the dressing is easy to adhere to the wound granulation tissue, causing dressing pain and damage to the new tissue

Method used

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  • Preparation method of aloe/sodium alginate double-layer hydrogel dressing
  • Preparation method of aloe/sodium alginate double-layer hydrogel dressing
  • Preparation method of aloe/sodium alginate double-layer hydrogel dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] a Preparation of non-toxic base layer sodium alginate hydrogel film

[0036] Dissolve 0.5g of sodium alginate powder in 100mL of distilled water, stir at room temperature until completely dissolved, add 0.6mL of plasticizer glycerin during stirring, exhaust for 12h, and stand at room temperature. Afterwards, a certain amount of sodium alginate gel was dripped into a petri dish to a height of 0.5 cm, and dried at a temperature of 37°C and a relative humidity of 50% for at least 24 hours.

[0037] b Preparation of the upper hydrogel loaded with drugs

[0038] Dissolve 5g of aloe vera in 100mL of distilled water, stir at room temperature until completely dissolved; then add appropriate amount of aloe vera solution to sodium alginate according to different mass ratios (A / SA mass ratios: 1, 3, 5), In the solution, aloe / sodium alginate mixtures with different mass ratios were prepared respectively, stirred and reacted at room temperature for 2 hours, exhausted for 24 hours, ...

Embodiment 2

[0046] a Dissolve 2.5g of sodium alginate powder in 100mL of distilled water, stir at room temperature until completely dissolved, add 1.2mL of plasticizer glycerin during stirring, exhaust for 12h, and let stand at room temperature. Afterwards, a certain amount of sodium alginate gel was dripped into a petri dish to a height of 0.5 cm, and dried at a temperature of 37°C and a relative humidity of 50% for at least 24 hours.

[0047] b Preparation of the upper hydrogel loaded with drugs

[0048] Dissolve 15g of aloe vera in 100mL of distilled water, stir at room temperature until completely dissolved; then add appropriate amount of aloe vera solution to sodium alginate according to different mass ratios (A / SA mass ratios: 1, 3, 5), In the solution, aloe / sodium alginate mixtures with different mass ratios were prepared respectively, stirred and reacted at room temperature for 2 hours, exhausted for 24 hours, and left standing at room temperature for later use.

[0049] c Prepar...

Embodiment 3

[0056] a Dissolve 5g of sodium alginate powder in 100mL of distilled water, stir at room temperature until completely dissolved, add 6mL of plasticizer glycerin during stirring, exhaust for 12h, and stand at room temperature. Afterwards, a certain amount of sodium alginate gel was dripped into a petri dish to form a height of 0.5 cm, and dried at a temperature of 37°C and a relative humidity of 50% for at least 24 hours.

[0057] b Preparation of the upper hydrogel loaded with drugs

[0058] Dissolve 25g of aloe vera in 100mL distilled water, stir at room temperature until completely dissolved; then add appropriate amount of aloe vera solution to sodium alginate according to different mass ratios (A / SA mass ratios: 1, 3, 5), In the solution, aloe / sodium alginate mixtures with different mass ratios were prepared respectively, stirred and reacted at room temperature for 2 hours, exhausted for 24 hours, and left standing at room temperature for later use.

[0059] c Preparation ...

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Abstract

The invention discloses a preparation method of aloe / sodium alginate double-layer hydrogel dressing. The method includes: adding plasticizer glycerol into sodium alginate aqueous solution, stirring, performing ultrasonic treatment, standing at room temperature to obtain sodium alginate gel, dripping the sodium alginate gel into a culture dish, and drying to obtain a sodium alginate substrate layer; adding aloe aqueous solution into the sodium alginate aqueous solution, stirring, performing ultrasonic treatment, and standing at room temperature to obtain aloe / sodium alginate mixed gel; dripping the aloe / sodium alginate mixed gel on the surface of the sodium alginate substrate layer, and drying; soaking the double-layer hydrogel film into CaCl2 solution for 5-20 minutes, then washing with distilled water, and drying to obtain the aloe / sodium alginate double-layer hydrogel dressing. The method has the advantages that the hydrogel dressing with high transparency and swelling rate is prepared through the simple method, and the prepared dressing has excellent antibacterial performance, can promote fibroblast proliferation ability, and has weak sensitization and no irritation to the skin.

Description

technical field [0001] The invention relates to a preparation method of an aloe / sodium alginate double-layer hydrogel dressing. Background technique [0002] At present, absorbent cotton, gauze, and bandages are commonly used dry dressings in hospitals to treat wounds, which have played a certain role in early wound healing, but there are still many shortcomings: such as dry dressings have poor air permeability, and can easily lead to exogenous infections when soaked ; Can not maintain the moisture of the wound, delay the healing of the wound; can cause foreign body reactions, seriously affecting the healing of the wound; the dressing is easy to adhere to the granulation tissue of the wound, causing pain in dressing change and damage to the new tissue. In order to overcome the above shortcomings, the researchers based on Dr. Winter's "moist wound healing theory" (the wound healing speed in a closed and humid environment is twice as fast as that of a dry wound exposed to air)...

Claims

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Application Information

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IPC IPC(8): A61L15/42A61L15/28A61L15/46
Inventor 王金清林茜茜杨生荣范增杰刘斌
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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