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Polymer, preparation method and poly-N-isopropylacrylamide europium complex micelle

A technology of isopropylacrylamide and polymethacrylic acid, applied in the field of europium complexes, can solve the problems of unstable micelles, easily affected by pH., solvent, temperature and ionic strength, etc.

Inactive Publication Date: 2015-11-25
CHANGCHUN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It is very simple to form micelles by self-assembly in selective solvents, but the obtained micelles are unstable and easily affected by pH., solvent, temperature and ionic strength, so a method for synthesizing stable micelles is needed, In recent years, cross-linking technology has provided a method for the stabilization of micelles, such as redox cross-linking of disulfide bonds, core cross-linking and shell cross-linking of micelles, etc.

Method used

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  • Polymer, preparation method and poly-N-isopropylacrylamide europium complex micelle
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  • Polymer, preparation method and poly-N-isopropylacrylamide europium complex micelle

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preparation example Construction

[0042] The present invention also provides a kind of preparation method of polymer, this method comprises:

[0043] Step 1: Reaction of α-haloacyl halide and polyethylene glycol monomethyl ether to obtain ATRP initiator mPEG 23 -X, where X is a halogen;

[0044] Step 2: In the Cu(I)X organic ligand catalytic system, the ATRP initiator mPEG obtained in Step 1 23 -X reacts with N-isopropylacrylamide to obtain polyethylene glycol monomethyl ether-polyN-isopropylacrylamide mPEG 23 -PNIPAM.

[0045] Step 3: In the Cu(I)X organic ligand catalytic system, the polyethylene glycol monomethyl ether-poly N-isopropylacrylamide and N,N-diethylaminoethyl methacrylate obtained in Step 2 Reaction to obtain the polymer polyethylene glycol monomethyl ether-poly N-isopropylacrylamide-polymethacrylate N,N-diethylaminoethyl ester mPEG 23 -PNIPAM-PDEA.

[0046] According to the present invention, add polyethylene glycol monomethyl ether (mPEG) in reaction vessel earlier 23 -OH) and solvent, s...

Embodiment 1

[0056] 250mgPEG 23 -OH and 30ml anhydrous CH 2 Cl 2 Add it to a 250ml single-necked flat-bottomed flask, then add 25μl triethylamine, place it in an ice-water bath, and add 5ml of anhydrous dichloromethane dissolved with 25μl of 2-bromoisobutyryl bromide in a constant pressure dropping funnel , drop for half an hour, seal well, stir and react at room temperature for 24 hours, after the reaction in dichloromethane, directly wash three times with NaCl aqueous solution, dry the extract with anhydrous magnesium sulfate, filter to remove magnesium sulfate, and spin The dichloromethane was removed by the evaporator, and the product was precipitated in excess glacial ether, filtered to obtain a white precipitate, and vacuum-dried at room temperature for 24 hours to obtain the macromolecular initiator mPEG 23 -Br;

[0057] Add 110mg initiator mPEG to one side of tube W 23 -Br, 904mgNIPAM and 8ml solvent, the solvent is DMF and water (V / V=1:1), add 10mgCuCl and 1ml deionized water ...

Embodiment 2

[0061] 2.5gPEG 23 -OH and 30ml anhydrous CH 2 Cl 2 Add it to a 250ml single-necked flat-bottomed flask, then add 250μl triethylamine, place it in an ice-water bath, and add 5ml of anhydrous dichloromethane dissolved in 250μl of 2-bromoisobutyryl bromide in a constant pressure dropping funnel , drop for half an hour, seal well, stir and react at room temperature for 48 hours, after the reaction in dichloromethane, directly wash three times with NaCl aqueous solution, dry the extract with anhydrous magnesium sulfate, filter to remove magnesium sulfate, and spin The dichloromethane was removed by the evaporator, and the product was precipitated in excess glacial ether, filtered to obtain a white precipitate, and vacuum-dried at room temperature for 48 hours to obtain the macromolecular initiator mPEG 23 -B;

[0062] Add 110mg initiator mPEG to one side of tube W 23 -Br, 1.13g NIPAM and 10ml solvent, the solvent is DMF and water (V / V=1:2), add 10mgCuCl and 1ml deionized water ...

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Abstract

The invention provides a polymer, a preparation method and a poly-N-isopropylacrylamide europium complex micelle, and belongs to the field of europoium complexes. The polymer is methoxypolyethylene glycol-poly-N-isopropylacrylamide-polymethylacrylic acid N,N-diethylaminoethyl, the structural formula is shown as the formula I, and the abbreviate formula is mPEG23-PNIPAM-PDEA, wherein mPEG23 is methoxypolyethylene glycol, PNIPAM is poly-N-isopropylacrylamide, and PDEA is polymethylacrylic acid N,N-diethylaminoethyl. The structural formula of the europium complex micelle is shown as the formula II. Due to the fact that the polymer (mPEG23-PNIPAM-PDEA) has good thermosensitivity and pH sensibility, the polymer can be used as a chemical conveying carrier after being prepared into the europium complex micelle.

Description

technical field [0001] The invention belongs to the field of europium complexes, and in particular relates to a polymer, a preparation method and poly-N-isopropylacrylamide europium complex micelles. Background technique [0002] Poly(N-isopropylacrylamide) (PNIPAM) is the most studied polymer among temperature-sensitive polymers, because its lower critical solution temperature (LCST, 32°C) is closer to human body temperature. In dilute aqueous solution, PNIPAM homopolymer will undergo a phase transition at 32°C, that is, within a narrow temperature range of 1-2°C, the phase transition behavior between single chains and molten balls will occur. Studies have shown that grafting PNIPAM onto a flat or spherical surface will have many practical applications, such as drug delivery, solute separation, enzyme-catalyzed carriers, and protein adsorption, all of which use the temperature sensitivity of PNIPAM to adjust the thickness of the PNIPAM layer. And its permeability, so as to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F293/00C08F220/54C08F220/34C08F8/42C08J3/00A61K47/32
Inventor 段潜高峰李艳伟高波常晶晶王恒国
Owner CHANGCHUN UNIV OF SCI & TECH
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