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3-hydroxy-propionaldehyde high-producing strain and application thereof in preventing and treating skin infection in mammals

A technology for high production of hydroxypropionaldehyde and skin infection, which can be applied in microorganism-based methods, skin diseases, anti-infective drugs, etc., can solve problems such as unsatisfactory treatment effect, toxic and side effects, and achieve prevention or treatment of skin infections and shortened growth cycle. , broad-spectrum antibacterial effect

Inactive Publication Date: 2015-11-25
吴前进
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But most of the western medicines contain hormones, which remain in the human body after medication, which can cause some toxic and side effects; in addition, the therapeutic effect is not satisfactory.

Method used

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  • 3-hydroxy-propionaldehyde high-producing strain and application thereof in preventing and treating skin infection in mammals
  • 3-hydroxy-propionaldehyde high-producing strain and application thereof in preventing and treating skin infection in mammals
  • 3-hydroxy-propionaldehyde high-producing strain and application thereof in preventing and treating skin infection in mammals

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Embodiment 1

[0035] The method for producing 3-hydroxypropionaldehyde of the probiotic high-producing strain of the present invention is carried out according to the following steps:

[0036] 1. Preparation of culture medium: peptone 10g, beef extract 10g, glucose 20g, yeast extract 5g, Tween 801ml, dipotassium hydrogen phosphate 2g, triammonium citrate 2g, sodium acetate 5g, magnesium sulfate 0.5g, manganese sulfate 0.2g , 0.5g of L-cysteine, 0.05g of sodium thioglycolate, 120.005g of VB, 3.68g of glycerin, add water to make the volume to 1L, adjust the pH to 6.8;

[0037] 2. Put the Lactobacillus reuteri RS01 of the present invention into the medium prepared in step 1, and anaerobic fermentation at 37°C for 5 hours;

[0038] 3. Separation: The first separation adopts plate and frame separation, which collects the bacteria quickly and is not easy to cause the death of the bacteria; then connect the separated bacteria to a new culture medium at 37°C and 0 dissolved oxygen , Incubate for 4 hours;...

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Abstract

The invention discloses a 3-hydroxy-propionaldehyde high-producing strain and application thereof in preventing and treating skin infection in mammals, relates to a microorganism and a composition thereof, and in particular relates to a microorganism and a composition thereof for preventing and treating skin infection in mammals, aiming at providing lactobacillus reuteri which is short in growth cycle and high in probiotic yield as well as application of the lactobacillus reuteri in preventing and treating skin infection in mammals. The 3-hydroxy-propionaldehyde high-producing strain disclosed by the invention is lactobacillus reuteri RS01 which is preserved in China General Microbiological Culture Collection Center on November 14, 2014 with preservation number of CGMCC No. 9971. The 3-hydroxy-propionaldehyde high-producing strain disclosed by the invention is easy to culture, high in target product yield and broad-spectrum in antibacterial effect, and fermentation liquid of the strain is safe and free from toxic or side effect. The 3-hydroxy-propionaldehyde high-producing strain disclosed by the invention is applicable to the field of preventing and treating skin infection in mammals.

Description

Technical field [0001] The invention relates to a microorganism and a composition thereof, in particular to a microorganism and a composition thereof for preventing and treating skin infections of mammals. Background technique [0002] Probiotic 3-hydroxypropionaldehyde (3-HPA), CAS: 2134-29-4, molecular formula C 3 H 6 O 2 , Soluble in ethanol, ether, acetone, very soluble in water, easy to polymerize, belongs to the aldol compound, relatively active in nature, no peculiar smell. Probiotic 3-hydroxypropionaldehyde mainly presents three states of 3-hydroxypropionaldehyde monomer, hydrate and cyclized dimer in aqueous solution. 3-Hydroxypropionaldehyde has an aldehyde group and a hydroxyl group, and it is prone to react with the aldehyde group and is easy to condense. [0003] Probiotic 3-hydroxypropionaldehyde can be produced by bacteria colonizing the intestines of humans and animals by metabolizing glycerol. It is widely used in biological sterilants, anti-infective therapeutics...

Claims

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Application Information

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IPC IPC(8): C12N1/20C12P7/24A61K35/747A61P17/00A61P31/00C12R1/225
Inventor 吴前进
Owner 吴前进
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