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Application of heteropolyblue to near-infrared photothermic treatment

A near-infrared light, heteropoly blue technology, applied in medical preparations containing active ingredients, wave energy or particle radiation treatment materials, drug combinations, etc., to achieve the effects of good photothermal stability, easy availability of raw materials and low price

Inactive Publication Date: 2015-12-09
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are few reports about the use of heteropoly blue as a photothermal conversion reagent.

Method used

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  • Application of heteropolyblue to near-infrared photothermic treatment
  • Application of heteropolyblue to near-infrared photothermic treatment
  • Application of heteropolyblue to near-infrared photothermic treatment

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0030] The heteropoly blue [N(CH 3 ) 4 ] 5 [PMo 2 W 10 o 40 ]·4H 2 O is a blue-black solid powder. The preparation method refers to the master's degree thesis of Northeast Normal University (Liu Zhengxi: Synthesis, crystal structure and magnetic research of polyacid complexes based on single / double vacancy Keggin type anions), mainly including the following steps:

[0031] (1) Refer to page 100, Chapter 3, Volume 27 of InorganicSynthesis to synthesize the required precursor Na 9 PW 9 o 34 ;

[0032] (2) With the synthesized precursor Na 9 PW 9 o 34 as raw material, adding N 2 h 4 ·H 2 The resulting [Mo 2 o 4 ] 2+ , adjust the pH of the solution, and stir under hydrothermal conditions to obtain the final material [N(CH 3 ) 4 ] 5 [PMo 2 W 10 o 40 ]·4H 2 O.

Embodiment 1

[0034] Weigh 4 mg of the prepared heteropoly blue solid and dissolve it in 10 mL of secondary water to make a 400 μg / mL solution. After ultrasonic dispersion, take 1 mL of the sample and place it in a fluorescence cuvette. The cuvette was placed in a dark box and irradiated with 808nm laser light until the temperature of the solution reached a plateau and the laser light was stopped. Real-time monitoring is carried out with an infrared thermal imager while illuminating, and the temperature change of the sample solution is received through a near-infrared photothermal imaging software system. The result is as Figure 4 As shown in the curve, under the irradiation of 808nm laser, the temperature rises by about 9°C within 5 minutes.

[0035] figure 1 Shown is the XRD spectrum of the heteropoly blue of this embodiment, wherein 15°-30° corresponds to the peak of the anion part, and 7.86°, 8.84°, 9.36° correspond to the strong peak of the cation part, which is the same as that giv...

Embodiment 2

[0037] Measure 2 mL of the 400 μg / mL heteropoly blue solution prepared in Example 1, add 2 mL of secondary water to form a 200 μg / mL solution, and take 1 mL of the sample and place it in a fluorescent cuvette. The cuvette was placed in a dark box and irradiated with 808nm laser light until the temperature of the solution reached a plateau and the laser light was stopped. Real-time monitoring is carried out with an infrared thermal imager while illuminating, and the temperature change of the sample solution is received through a near-infrared photothermal imaging software system. The result is as Figure 4 As shown in the curve, under the irradiation of 808nm laser, the temperature rises by about 6°C within 5 minutes.

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Abstract

The invention relates to an application of heteropolyblue to near-infrared photothermic treatment. A chemical formula of the heteropolyblue is [N(CH3)4]5[PMo2W10O40].4H2O and the heteropolyblue is used for preparing a photothermic conversion reagent for the near-infrared photothermic treatment of cancer cells; when the photothermic conversion reagent is used for the near-infrared photothermic treatment of the cancer cells, specific steps are as follows: the photothermic conversion reagent is added into a 1640 culture medium, the cancer cells are incubated for 4 to 6 hours and are irradiated for 10 to 20 minutes with 808nm laser, and the survival rate of the cancer cells is detected by adopting an MTT colorimetric method. Compared with the prior art, the heteropolyblue [N(CH3)4]5[PMo2W10O40].4H2O has a good absorbing effect and good photothermic conversion capability in a near-infrared light area, and the photothermic conversion reagent for the near-infrared photothermic treatment of the cancer cells, which is prepared from the heteropolyblue, has the advantages of high photothermic conversion efficiency and good photothermic stability.

Description

technical field [0001] The invention belongs to the technical field of near-infrared photothermal conversion materials, and relates to the application of heteropoly blue in near-infrared photothermal therapy. Background technique [0002] Heteropoly blue is the reduction product of heteropoly acid and its salt. It is a general term for a large class of heteropoly acid salts of transition metals such as molybdenum and tungsten in low valence. Most of them are mixed valence compounds with complex composition. Stable, with variable oxidation state, electrical conductivity, photosensitivity and diversity of colors in different oxidation states, etc. After the reduction of heteropolyacids and their salts, although a few present other colors, most of them are dark blue, so it is customarily called "HeteropolyBlue". Heteropoly blue is a mixed valence complex. According to the different properties of various heteropolyanions, one or more electrons can be introduced after reduction...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61P35/00
Inventor 杨红严玉萍石敏靳红玉王杰
Owner SHANGHAI NORMAL UNIVERSITY
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