Lumen stent capable of conducting development absorption and preparation method and application thereof

A lumen and contrast agent technology, applied in medical science, surgery, coating, etc., can solve technical difficulties and other problems, achieve wide application prospects, low water absorption, and good biocompatibility

Active Publication Date: 2015-12-16
青岛健康海洋生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the limitation of solubility, it has technical difficulties in practical application

Method used

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  • Lumen stent capable of conducting development absorption and preparation method and application thereof
  • Lumen stent capable of conducting development absorption and preparation method and application thereof
  • Lumen stent capable of conducting development absorption and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A luminal stent that can be developed and absorbed is characterized by a hollow tubular structure made of acylated amino polysaccharide, the outer surface of the tubular structure has a developing coating, and the tube wall has or does not have a transparent hole structure or pattern structure .

[0035] The acylated amino polysaccharide is a polyacylated glucosamine polysaccharide, the total degree of acylation in its molecular structure is greater than or equal to 70%, and the acyl group is acetyl, propionyl, butyryl, hexanoyl, octanoyl, One or more of caproyl, lauroyl, palmitoyl and other aliphatic or aromatic acyl groups, the molecular structure formula of acylated amino polysaccharide is:

[0036]

[0037] In the formula, R 1 , R 2 or R 3 is H, acetyl (-C2 h 3 O), propionyl (-C 3 h 5 O), butyryl (-C 4 h 7 O), caproyl (-C 6 h 11 O), octanoyl (-C 8 h 15 O) or one or more of caproyl, lauroyl, palmitoyl and other aliphatic or aromatic acyl groups, the de...

Embodiment 2

[0040] Example 2 Screening of the absorbable luminal stent substrate:

[0041] (1) Preparation of diaphragm:

[0042] The preparation of chitosan diaphragm: take chitosan powder (deacetylation degree 92.5%) 2g, add 2% acetic acid aqueous solution (volume fraction) 100ml, stir and dissolve, be mixed with weight volume ratio (w / v) be 2 % chitosan glue. Measure 15ml of chitosan glue respectively, place them in a PP square plate with a side length of 50mm×50mm, and let it dry in a fume hood. The dried membrane is placed in 2% NaOH aqueous solution (weight percent concentration, the same below) for acid-base neutralization, washed with water until the pH is neutral, and dried to obtain a chitosan membrane.

[0043] Preparation of chitin film: Weigh 2 g of chitin powder, add 100 ml of hexafluoroisopropanol solution, stir to dissolve, and prepare 2% chitin glue (w / v). Measure 15ml of chitin glue respectively, place them in a stainless steel square plate with a side length of 50mm×...

Embodiment 3

[0052] Example 3 Preparation of the absorbable lumen stent tubing 1:

[0053] Weigh 20g of chitosan powder (deacetylation degree 92%), put it into a glass reaction vessel, add 50mL of acylating reagent acetic anhydride solution, add 100ml of methanol, control the temperature at 10°C, add 70% perchloric acid solution under stirring 1ml was used as a catalyst, and the reaction was stirred for 36h. After the reaction is complete, filter, separate the solid from the liquid, put the solid into 5% NaOH aqueous solution, neutralize the acid and alkali, centrifuge, separate the solid from the liquid, elute the salt from the solid with water, dehydrate with 95% ethanol, heat and dry at 60°C to obtain acylation Acylated amino polysaccharide 1 with a degree of 74.5%. Acylated amino polysaccharide 1 has an acetyl structure with an acetyl content of 74.5%.

[0054] Take by weighing 2.5g of the above-mentioned acylated amino polysaccharide 1, add 61ml of hexafluoroisopropanol solution (sp...

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Abstract

The invention discloses a lumen stent capable of conducting development absorption. The lumen stent is characterized in that the lumen stent is of a hollow tubular structure and made ofacyl amino polysaccharide, the outer surface of the tubular structure is provided with a development coating, and the tube wall is provided with or not provided with a transparent hole structure or a pattern structure. The lumen stent can be used as a blood vessel stent, a biliary stent or a urethral stent and is used for treating narrowing of the blood vessel, the bile duct and the urine tube cavity, capable of conducting development, capable of being degraded and absorbed in a human body, the situation that the lumen stent stays in the body for a long time can be avoided, and the lumen stent has wide market prospect.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a luminal stent material, in particular to a luminal stent capable of developing and absorbing, and a preparation method and application thereof. Background technique [0002] Lumenal stents have a wide range of clinical applications and can be used for esophageal stents, bile duct stents, urethral stents, artificial blood vessels, etc. Bile duct stent is used for the treatment of pancreaticobiliary duct obstruction and cholestasis caused by pancreaticobiliary malignant tumors. Urethral stents are used to treat urethral strictures that make it difficult to pass urine due to enlarged prostate glands that compress the urethra. Artificial blood vessels, especially small-diameter artificial blood vessels (diameter ≤ 6mm), are used to replace small peripheral blood vessels that are diseased or defective in order to improve the blood supply to peripheral tissues of the body. Small-d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/14A61L31/08A61L31/18C08B37/08
Inventor 刘万顺
Owner 青岛健康海洋生物制药有限公司
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