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Preparation method and purpose of sodium fluoride sustained-release tablets

A technology of sodium fluoride and sustained-release tablets, which is applied in the field of medical chemistry, can solve the problems of dental fluorosis, poisoning, and the inability of fluoride ions to achieve a therapeutic effect, and achieves the inhibition of dental caries, the sustained-release effect is obvious, and the preparation method is simple and easy to operate. Effect

Inactive Publication Date: 2015-12-23
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, a variety of fluoride anti-caries technologies have been widely used in the world, but when the concentration of fluoride is too high, it may lead to acute and chronic fluorosis and dental fluorosis, and when the concentration of fluoride ion is low, no obvious treatment can be achieved. Effect

Method used

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  • Preparation method and purpose of sodium fluoride sustained-release tablets
  • Preparation method and purpose of sodium fluoride sustained-release tablets
  • Preparation method and purpose of sodium fluoride sustained-release tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Preparation of hollow titanium dioxide loaded with sodium fluoride

[0033] To prepare hollow titanium dioxide with a wall thickness of 25nm, weigh 2g of microspheres in a 50mL round bottom flask, slowly add 7.9mL of 0.6mol / L sodium fluoride solution dropwise after vacuuming for 30min, continue vacuuming for 30min, stir, and dry to obtain a loading capacity of 10% Nano Hollow Titanium Dioxide.

[0034] (2) Preparation of Sodium Fluoride Sustained Release Tablets

[0035] Weigh 1g of the prepared hollow titanium dioxide loaded with sodium fluoride into 5mL of Gruma general-purpose binder, stir evenly, pour the mixed solution into the template, and irradiate with a light curing machine to obtain sustained-release tablets with a diameter of 15mm. A disc with a thickness of 2.3mm and a mass of 0.8g.

[0036] (3) In vitro release test of sodium fluoride sustained release agent

[0037] Take two prepared sustained-release tablets and place them in 30mL of artificial sa...

Embodiment 2

[0039] Hollow titanium dioxide with a wall thickness of 35 nm was prepared, and the method in Example 1 was used to prepare hollow titanium dioxide loaded with sodium fluoride. Weigh 1g of the prepared hollow titanium dioxide loaded with sodium fluoride in 5mL of Gruma general-purpose binder, stir evenly, pour it into the template, and irradiate it with a light curing machine to obtain a slow-release tablet, which is made into a diameter of 15mm and a thickness of 2.3mm, a disc with a mass of 0.8g. Take two prepared slow-release tablets and put them in 30mL of artificial saliva, take 2.0mL samples respectively on the 1d, 3d, 7d, 12d, 20d, 32d, and 50d to measure the fluoride ion concentration, and replace the model tablet after measurement. 30mL of artificial saliva. Add up the released amounts of fluoride ions in the taken solutions to obtain the cumulative F - release amount, recorded as mg / L; from figure 2 It can be seen that from the 1st day to the 50th day, the releas...

Embodiment 3

[0041] Hollow titanium dioxide with a wall thickness of 39 nm was prepared, and the method of Example 1 was used to prepare hollow titanium dioxide loaded with sodium fluoride. Weigh 1g of the prepared hollow titanium dioxide loaded with sodium fluoride in 5mL of Gruma general-purpose binder, stir evenly, pour it into the template, and irradiate it with a light curing machine to obtain a slow-release tablet, which is made into a diameter of 15mm and a thickness of 2.3mm, a disc with a mass of 0.8g. Take two prepared slow-release tablets and put them in 30mL of artificial saliva, take 2.0mL samples respectively on the 1d, 3d, 7d, 12d, 20d, 32d, and 50d to measure the fluoride ion concentration, and replace the model tablet after measurement. 30mL of artificial saliva. Add up the released amounts of fluoride ions in the taken solutions to obtain the cumulative F - release amount, recorded as mg / L; from image 3 It can be seen that from the 1st day to the 50th day, the release...

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Abstract

The invention provides a preparation method of sodium fluoride sustained-release tablets. A carrier for loading sodium fluoride is hollow titanium dioxide. The preparation method includes: using a hard template method to prepare the hollow titanium dioxide, and allowing the sodium fluoride to evenly soak the hollow titanium dioxide under a negative pressure condition (-0.1MPa). The sustained-release performance of the sodium fluoride is regulated and controlled by adjusting the wall thickness and sodium fluoride loading capacity of the titanium dioxide. The preparation method has the advantages that the hollow titanium dioxide used in the method is regular in morphology, adjustable in wall thickness, large in internal space, low in toxicity and the like, medicine release performance is improved, and practicality is enhanced.

Description

technical field [0001] The invention belongs to the field of medical chemistry, and in particular relates to a preparation method of sodium fluoride sustained-release tablets which can be used for sustained-release of medicines. Background technique [0002] Titanium dioxide is a biomaterial with good biocompatibility. Studies have verified that nano-titanium dioxide (TiO 2 ) particles can be phagocytized by macrophages in normal tissues without causing side effects such as leukopenia. The use of nano-titanium dioxide may be used to treat certain hollow organs, such as the mouth, digestive tract, esophagus, cervix, vagina or skin surface, etc. site of tumors. The polarity of the Ti-O bond in titanium dioxide is relatively large, and the water adsorbed on the surface dissociates due to polarization, and easily forms hydroxyl groups, which can improve the performance of titanium dioxide as a drug carrier. [0003] Dental caries is a disease of chronic and progressive destru...

Claims

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Application Information

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IPC IPC(8): A61K33/16A61K47/02A61K9/22A61P1/02
Inventor 季玉琴殷恒波王爱丽沈灵沁朱晓燕胡永明侯祥祥司阳
Owner JIANGSU UNIV
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