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Kudzuvine root extract, extracting method and dropping pill of kudzuvine root extract

A technology of puerarin extract and extraction method, applied in the directions of pill delivery, drug combination, pharmaceutical formulation, etc., can solve the problems of low oral bioavailability, low solubility of puerarin, damage to operator's health, etc., and achieves improved bioavailability, The effect of low cost and convenient operation

Inactive Publication Date: 2015-12-23
宜诺(天津)医药工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above method has many links, and a large amount of flammable and toxic organic solvents are used, which is easy to cause environmental pollution and damage to the health of the operator, high production cost, long cycle, and many impurities in the product, low puerarin content, etc.
The solubility of puerarin in water is relatively low, only 4.6g / L, the absorption is incomplete, and the oral bioavailability is low. Only a relatively large dose can be taken orally in clinical practice to achieve effective blood concentration and therapeutic effect, so it is widely used clinically. for injection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A method for extracting kudzu root extract, comprising the steps of:

[0024] (1) puerariae is crushed into the coarsest powder, the coarsest powder of 1000g puerariae root is taken, the volume concentration of adding 10 times of the weight of the puerariae root is the 80% ethanol aqueous solution, soaked at room temperature for 3 times, each time for 24 hours, filtered, combined Filtrate, recover ethanol under reduced pressure and concentrate to no ethanol, filter;

[0025] (2) the filtrate obtained by step (1) is passed through the macroporous adsorption resin AB-8 column, and the resin bed is washed with the hydrochloric acid aqueous solution of pH=7 of 10 times of column volume, after washing the column, the volume of 5 times of column volume is The concentration is 80% ethanol aqueous solution for elution, the eluate is collected, the ethanol is recovered under reduced pressure, concentrated, and dried in vacuum to obtain a dry extract, which is pulverized. The we...

Embodiment 2

[0028] A method for extracting kudzu root extract, comprising the steps of:

[0029] (1) puerariae is crushed into the coarsest powder, the coarsest powder of 1000g puerariae root is taken, the volume concentration of adding the volume concentration of 2 times of the coarsest puerariae powder weight is an ethanol aqueous solution of 85%, soaked at room temperature 4 times, each time for 12 hours, filtered, combined Filtrate, recover ethanol under reduced pressure and concentrate to no ethanol, filter;

[0030] (2) the filtrate that step (1) is obtained is passed through macroporous adsorption resin D101 post, with the hydrochloric acid aqueous solution washing resin bed of the pH=2 of 10 times of amount of column volume, after washing column, with the volumetric concentration of 5 times of amount of column volume is Elute with 90% ethanol aqueous solution, collect the eluent, recover ethanol under reduced pressure, concentrate, and dry in vacuum to obtain a dry extract, which ...

Embodiment 3

[0033] A method for extracting kudzu root extract, comprising the steps of:

[0034] (1) Puerariae is pulverized into the coarsest powder, the coarsest powder of 1000g Puerariae root is taken, the volume concentration of adding the volume concentration of 5 times of the weight of the puerariae root is the 30% ethanol aqueous solution, soaked at room temperature twice, each time for 48 hours, filtered, combined Filtrate, recover ethanol under reduced pressure and concentrate to no ethanol, filter;

[0035] (2) The filtrate obtained in step (1) is passed through the macroporous adsorption resin HD-101 column, and the resin bed is washed with the hydrochloric acid aqueous solution of pH=5 of 3 times of column volume, after washing the column, the volume of 2 times of column volume is The concentration is 30% ethanol aqueous solution for elution, the eluate is collected, the ethanol is recovered under reduced pressure, concentrated, and dried in vacuum to obtain a dry extract, whi...

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PUM

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Abstract

The invention discloses a kudzuvine root extract, an extracting method of a dropping pill of the kudzuvine root extract. The extracting method of the kudzuvine root extract comprises the following steps: (1) grinding kudzuvine root into coarsest powder, adding an ethanol water solution, steeping at room temperature, filtering, combining filtrates, decompressing and concentration until ethanol does not exist and filtering; or grinding kudzuvine root into coarsest powder, adding an ethanol water solution, heating and refluxing, filtering, combining filtrates, decompressing and concentration until ethanol does not exist and filtering; and (2) processing filtrate by virtue of a macroporous adsorption resin column, washing by virtue of a hydrochloric acid water solution, eluting by virtue of an ethanol water solution, collecting an eluent, decompressing and concentrating, drying in a vacuum environment so as to obtain a dry extractum and grinding the dry extractum. The method disclosed by the invention is simple in process, low in cost, high in yield, simple in equipment required, controllable in quality, convenient to operate, economic and applicable to large-scale industrial production; the kudzuvine root extract is high in the content of puerarin which is above 55%; and the dropping pill disclosed by the invention is capable of improving bioavailability of medicines, and the dropping pill is rapid, efficient, convenient to take and high in stability.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and relates to a kudzu root extract, an extraction method and a kudzu root extract dropping pill. Background technique [0002] Pueraria lobata (willd) ohwi is the dried root of Pueraria lobata (willd) ohwi or Pueraria thomsonii Benth, a leguminous plant. It was originally a medicine commonly used in traditional Chinese medicine prescriptions. to treat cardiovascular disease. [0003] As a Chinese herbal medicine, kudzu root has complex components and contains various compounds. Among them, the composition of pueraria isoflavone is relatively high, and puerarin is the main compound in pueraria flavone. Studies in recent years have shown that this flavonoid compound has various pharmacological functions such as lowering blood pressure, increasing cerebral and coronary blood flow, improving myocardial metabolism, anti-myocardial ischemia, improving peripheral mic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/488A61K9/20A61P9/10A61K31/352
Inventor 王玉姝刘长青高媛
Owner 宜诺(天津)医药工程有限公司
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