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Anle tablet

A technology of Anle tablet and extractor, applied in the field of Anle tablet, can solve the problems of large dosage, slow effective effect, long disintegration time of Anle tablet, etc., and achieves the effects of high bioavailability, short reaction time and improved yield

Inactive Publication Date: 2015-12-23
韩志强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The drug obtained in the patent CN1739648A solved the shortcomings of the long disintegration time limit and slow effect of Anle tablets in the prior art, and prepared a traditional Chinese medicine preparation with antidepressant properties
[0006] For the preparation of antidepressant Chinese medicine Anle Tablets and other preparations, although different methods have been adopted in the prior art to avoid the shortcomings of large dosage and slow effect, the content of active ingredients in its extraction process has been improved to varying degrees, but its The effect is very small, so there is an urgent need for a product that can increase the content of its active ingredients, reduce the dosage, and have high bioavailability

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0055] Prescription: Bupleurum 90g, Angelica 135g, Chuanxiong 90g, Poria 180g, Uncaria 180g, Radix Shouwu 180g, Atractylodes macrocephala (stir-fried) 180g, licorice 68g;

[0056] Excipients: magnesium stearate 1.5g

[0057] Preparation:

[0058] 1) Ultrasonic extraction of active ingredients of Bupleurum, Angelica, and Atractylodes Rhizoma

[0059] The prescribed amount of Bupleurum, Angelica and Atractylodes Rhizome is crushed through a 50-mesh sieve, and the powder is mixed and added to an ultrasonic extractor and 70% ethanol is added until the medicinal materials are submerged, and soaked for 24 hours; after that, the ratio of the material and the solution in the extractor is adjusted to 1: 12. Heat the extractor until the temperature in the extractor is 40°C, set the ultrasonic power to 200W, and start ultrasonic extraction for 40 minutes;

[0060] Repeat the ultrasonication 3 times, filter, collect the filtrate and concentrate it into a dry extract, and recover the dre...

Embodiment 2

[0075] Prescription: Bupleurum 90g, Angelica 135g, Chuanxiong 90g, Poria 180g, Uncaria 180g, Radix Shouwu 180g, Atractylodes macrocephala (stir-fried) 180g, licorice 68g;

[0076] Excipients: magnesium stearate 1.5g

[0077] Preparation:

[0078] 1) Ultrasonic extraction of active ingredients of Bupleurum, Angelica, and Atractylodes Rhizoma

[0079] The prescribed amount of Bupleurum, Angelica and Atractylodes Rhizome is crushed through a 20-mesh sieve, and the powders are mixed and added to an ultrasonic extractor and 50% ethanol is added until the medicinal materials are submerged, and soaked for 48 hours; then adjust the ratio of the materials and the solution in the extractor to 1: 10. Heat the extractor until the temperature in the extractor is 35°C, set the ultrasonic power to 180W, and start ultrasonic extraction for 35 minutes;

[0080] Repeat the ultrasonication 3 times, filter, collect the filtrate and concentrate it into a dry extract, and recover the dregs for la...

Embodiment 3

[0095]Prescription: Bupleurum 90g, Angelica 135g, Chuanxiong 90g, Poria 180g, Uncaria 180g, Radix Shouwu 180g, Atractylodes macrocephala (stir-fried) 180g, licorice 68g;

[0096] Excipients: magnesium stearate 1.5g

[0097] Preparation:

[0098] 1) Ultrasonic extraction of active ingredients of Bupleurum, Angelica, and Atractylodes Rhizoma

[0099] The prescribed amount of Bupleurum, Angelica and Atractylodes Rhizome is crushed through a 70-mesh sieve, and the powders are mixed and added to an ultrasonic extractor and 80% ethanol is added until the medicinal materials are submerged, and soaked for 12 hours; after that, the ratio of the materials and the solution in the extractor is adjusted to 1: 20. Heat the extractor until the temperature in the extractor is 45°C, set the ultrasonic power to 220W, and start ultrasonic extraction for 45 minutes;

[0100] Repeat the ultrasonication 3 times, filter, collect the filtrate and concentrate it into a dry extract, and recover the d...

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Abstract

The invention relates to an Anle tablet and a preparation method thereof. Concretely, the preparation method comprises the steps of (1) carrying out ultrasonic extraction on effective components of radix bupleuri, angelica sinensis and white atractylodes rhizome; (2) carrying out continuous ethanol reflux extraction aiming at continuous concentration change of effective components of ligusticum wallichii, liquorice, uncaria, caulis polygoni multiflori and decoction dregs; (3) processing Tuckahoe, and mixing the Tuckahoe with thick paste; and (4) preparing the tablet. By using the preparation method disclosed by the invention, the Anle tablet which is high in bioavailability, excellent in effect and reduced in one-time dosage is obtained, and the clinical effect of the Anle tablet is ensured.

Description

Technical field: [0001] The present invention relates to an anole tablet, in particular, the present invention relates to an anole tablet and a preparation method thereof. Background technique: [0002] Anle Tablets is recorded in the Ministry of Health standard, its prescription is Bupleurum 90g, Angelica 135g, Chuanxiong 90g, Poria 180g, Uncaria 180g, Shouwuteng 180g, Atractylodes macrocephala (stir-fried) 180g, licorice 68g as raw materials, it can soothe the liver Yu, calm the nerves. It is used for mental depression, panic insomnia, chest tightness and discomfort, anorexia and mental fatigue, and is effective for neurosis, climacteric syndrome, children's night cry, teeth grinding and other symptoms. [0003] The extraction of active ingredients in the traditional preparation process usually adopts the method of powdering and boiling in water. The process is rough and backward, and there are many impurities, which leads to excessive dosage for patients and inconvenient...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61K9/28A61P25/24A61P25/20A61P39/00A61P25/00A61P15/12
Inventor 韩志强
Owner 韩志强
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