Composite alginate hydrogel dressing as well as preparation method and application thereof

A composite hydrogel and alginate technology, applied in medical science, bandages, absorbent pads, etc., can solve the problems of difficult preparation of dressing products, difficult control, violent reaction, etc., to achieve controllable gel strength and simple method , the effect of stable quality

Inactive Publication Date: 2015-12-23
吴玉松
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the complexation reaction between water-soluble inorganic metals (such as calcium chloride and zinc chloride) and alginic acid is violent, and the gelation reaction speed is usually very fast, which is difficult to control, and it is difficult to prepare dressing products with uniform structure and regular shape

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Weigh 1.5 grams of sodium alginate, disperse in 98.3 grams of distilled water, and stir at 60oC until completely dissolved. Cool to room temperature, add 0.2 g of calcium alginate, stir until dissolved evenly, and form an amorphous composite hydrogel.

Embodiment 2

[0015] Weigh 0.1 g of potassium alginate, disperse in 99.8 g of distilled water, and stir at 60°C until completely dissolved. Cool to room temperature, add 0.2 g of carboxymethyl chitosan calcium, and stir until it dissolves evenly, which is the amorphous composite hydrogel of the present invention.

Embodiment 3

[0017] Weigh 1.0 g of sodium alginate, disperse in 98.7 g of distilled water, and stir at 60°C until completely dissolved. Cool to room temperature, add 0.3 g of carboxymethyl cellulose calcium, stir until dissolved evenly, and form an amorphous composite hydrogel.

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PUM

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Abstract

The invention provides a composite hydrogel material containing alginate as well as a preparation method thereof. The method comprises the following steps: adding polyvalent metal modified carboxyl-containing water soluble polysaccharide and derivatives thereof as a gel cross-linking agent to an alginate (potassium salt, sodium salt or ammonium salt) water solution in advance, mixing and stirring, and directly casting a film so as to obtain gel or further drying so as to obtain a film. The method is simple in technology, and the obtained gel is good in intensity controllability and good in stability; and the gel has effects of promoting wound healing and accelerating wound tissue repairing.

Description

technical field [0001] The invention relates to a preparation method and application of a composite hydrogel dressing containing alginate, belonging to the field of biological materials. Background technique [0002] Modern medical theory has proved that providing a relatively moist and closed environment to the wound is conducive to wound healing. Based on this "moist therapy" theory, many liquid-absorbing swelling (ie gel-type) dressings have emerged as the times require. As an efficient bioadhesive and pH-sensitive gel material, alginate has been increasingly studied in its application. Alginate is a polysaccharide that provides the main structural component of brown algae. Alginate is formed by linking two monomers, mannuronic acid (M) and guluronic acid (G). The affinity of alginic acid to metal ions and its gel-forming performance are related to the content of G monomer. When two G monomers are linked, they form a pair of polyvalent metal ions (Ca 2+ , Zn 2+ 、Al 3...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/42A61L15/18A61L15/44A61L15/46
Inventor 吴玉松
Owner 吴玉松
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