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Preparation method for nanocapsule

A technology of nanocapsules and micro-nanospheres, used in microcapsule preparations, microcapsules, nanocapsules, etc., can solve problems such as poor stability and rupture of capsule walls, achieve mild preparation conditions, small capsule particle size, easy promotion and applied effect

Inactive Publication Date: 2015-12-30
NINGBO UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of the microcapsules prepared by a single self-assembly method is that the capsule wall is easily broken by conditions such as oxidation, reduction or hydrolysis during its preparation or application, resulting in poor stability; the researchers found that A certain degree of cross-linking or bonding between the self-assembled macromolecules can improve the stability of the microcapsules, such as chemical bonds, hydrogen bonds, thermal cross-linking, photo-cross-linking, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1, 1.5 ml of triton and 1.5 ml of n-hexanol were added to 7 ml of cyclohexane, 0.1 ml of deionized water was added under vigorous stirring at 30° C., and a uniform transparent microemulsion was obtained after stirring for 10 minutes.

[0015] Add 0.1 ml tetraethyl orthosilicate dropwise to the microemulsion, add dropwise 0.1 ml 25% ammonia water after stirring for 10 minutes, add N-isopropylacrylamide (NIPAAm) after reacting at 30°C for 1 hour, polyacrylic acid (PAA) and photoinitiator diethoxyacetophenone (DEAP), each 0.1ml, reacted for 1 hour.

[0016] Utilize ultraviolet light irradiation (with a power of 40-80 watts) for 1-30 minutes to initiate a polymerization reaction and form a core-shell structure.

[0017] The obtained colloidal particles with core-shell structure are added to an excess of hydrofluoric acid solution with pH=2, placed in a shaker to dissolve the silica template particles, and nanocapsules are obtained after washing. The size of the caps...

Embodiment 2

[0018] Example 2, 1.5 ml of triton and 1.5 ml of n-hexanol were added to 7 ml of toluene, vigorously stirred at 30° C. and 0.1 ml of deionized water was added, and a uniform transparent microemulsion was obtained after stirring for 10 minutes.

[0019] Add 0.1 ml tetraethyl orthosilicate dropwise to the microemulsion, add dropwise 0.1 ml 25% ammonia water after stirring for 10 minutes, add N-isopropylacrylamide (NIPAAm) after reacting at 30°C for 1 hour, polyacrylic acid (PAA) and photoinitiator diethoxyacetophenone (DEAP) each 0.1ml, reacted for 1 hour.

[0020] Utilize ultraviolet light irradiation (with a power of 40-80 watts) for 1-30 minutes to initiate a polymerization reaction and form a core-shell structure.

[0021] The obtained colloidal particles with core-shell structure are added to an excess of hydrofluoric acid solution with pH=2, placed in a shaker to dissolve the silica template particles, and nanocapsules are obtained after washing. The size of the capsules i...

Embodiment 3

[0022] Example 3, add 1.5 ml of Tween span80 and 1.5 ml of n-hexanol to 7 ml of cyclohexane, stir vigorously at 30° C., add 0.1 ml of deionized water, and stir for 10 minutes to obtain a uniform and transparent microemulsion.

[0023] Add 0.1 ml tetraethyl orthosilicate dropwise to the microemulsion, add dropwise 0.1 ml 25% ammonia water after stirring for 10 minutes, add N-isopropylacrylamide (NIPAAm) after reacting at 30°C for 1 hour, polyacrylic acid (PAA) and photoinitiator diethoxyacetophenone (DEAP) each 0.1 ml, reacted for 1 hour.

[0024] Utilize ultraviolet light irradiation (with a power of 40-80 watts) for 1-30 minutes to initiate a polymerization reaction and form a core-shell structure.

[0025] The obtained colloidal particles with core-shell structure are added to an excess of hydrofluoric acid solution with pH=2, placed in a shaker to dissolve the silica template particles, and nanocapsules are obtained after washing. The size of the capsules is about 10 nanome...

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Abstract

The invention provides a preparation method for a nanocapsule. The preparation method is characterized by comprising the following steps: (1) subjecting water, surfactant, cosurfactant and an oil phase to a stirring reaction at 10 to 80 DEG C for 2 min to 5 h so as to obtain a stable transparent microemulsion; (2) adding ethyl orthosilicate and ammonia water, carrying out a hydrolysis reaction for 0.1 to 12 h, then adding N-isopropyl acrylamide, polyacrylic acid and a photoinitiator diethoxyacetophenone and carrying out a reaction for 0.1 to 12 h so as to obtain micro-nano spheres; (3) subjecting the micro-nano spheres to ultraviolet irradiation so as to initiate polymerization of function groups; and (4) removing silica particles so as to obtain the nanocapsule. Compared with the prior art, the invention has the following advantages: since a reversed-phase microemulsion process is employed to prepare a template, the nanocapsule has a small particle size; and poly(N-isopropyl acrylamide) and polyacrylic acid are used as capsule wall materials, so double responsiveness to a pH value and temperature is obtained.

Description

technical field [0001] The invention relates to a preparation method of capsules. Background technique [0002] There are three main preparation techniques for drug sustained-release micro-nanocapsules: one method is to use dendrimers or hyperbranched macromolecules to construct microcapsules, and the preparation cost of the template particles is very expensive; the other method is to use macromolecules Molecules form microcapsules directly at the oil-water two-phase interface through self-assembly into a film or interfacial polymerization; for example, liposome molecules aggregate to form a double-layer spherical closed structure called vesicles at low concentrations, or amphiphilic block copolymers in aqueous solution self-assemble into vesicles. Although the preparation steps of the interfacial polymerization method are simple, there are harsh preparation conditions, large particle size of the obtained capsules and insufficient firmness of the capsule wall, which limit t...

Claims

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Application Information

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IPC IPC(8): B01J13/02A61K9/51A61K47/32
Inventor 金谊陈斌王江波王志强
Owner NINGBO UNIVERSITY OF TECHNOLOGY
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