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Applications of eleven-component golden pills in preparation of medicine treating hyperlipemia

A technology for hyperlipidemia and hypercholesterolemia, applied in the field of medicine, can solve problems such as undetected hyperlipidemia

Active Publication Date: 2016-01-06
SHANDONG JINHE DRUG RES DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at present, including literature, patents, practical applications, etc., no research has been found that it can be used to treat hyperlipidemia

Method used

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  • Applications of eleven-component golden pills in preparation of medicine treating hyperlipemia
  • Applications of eleven-component golden pills in preparation of medicine treating hyperlipemia
  • Applications of eleven-component golden pills in preparation of medicine treating hyperlipemia

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1、 10

[0017] Experimental Example 1. Effect of Shishiwei Jinjin Pills on Hyperlipidemia in Experimental Animals

[0018] 1. Materials and samples: Shishiwei Jinjin Pills (Qinghai Jinhe Tibetan Medicine Pharmaceutical Co., Ltd., batch number 20121015), recommended dose, 3 pills each time, 2 times a day for adults, that is 0.022g / kg.bw. After crushing, distilled water is used to prepare different concentrations; high-fat feed: 78.8% basic feed, 1% cholesterol, 10% egg yolk powder, 10% lard, 0.2% bile salt. Xuezhikang Capsules, produced by Beijing Beida Weixin Biotechnology Co., Ltd., batch number 20120121, recommended dosage for human body: 2 times a day, 2 capsules each time, 0.3g per capsule.

[0019] 2. Experimental animals and grouping: 60 Wistar rats, male, weighing 160-200 g, provided by the Experimental Animal Center of Shandong University, certificate number: scxk (Lu) 20110004. Feed the basal feed for one week in a laboratory environment, measure body weight, and draw tail b...

experiment example 2、 10

[0038] Experimental Example 2. Clinical Observation of Shishiwei Jinjin Pills in Treating Patients with Hyperlipidemia

[0039] 1. Materials and methods

[0040] 1.1 General Information

[0041] 46 patients with hyperlipidemia were all diagnosed with reference to the diagnostic criteria for hyperlipidemia in the "Guiding Principles for Clinical Research of New Chinese Medicines (Trial)". Under normal diet, the fasting blood lipid level total cholesterol (TC) ≥ 5.72mmol / L or / and Triglyceride (TG) ≥ 1.70mmol / L or / and low-density cholesterol (LDL-C) > 3.64mmol / L. Among them, there were 21 males and 25 females; the age ranged from 41 to 70 years, with an average age of (55.1±8.4) years; the course of disease ranged from 1 to 9 years, with an average course of (4.9±2.1) years; those who met the above diagnostic criteria for dyslipidemia belonged to primary Patients with chronic dyslipidemia, excluding patients with cerebrovascular accident, myocardial infarction, severe trauma or...

Embodiment 1、 10

[0060] Example 1, Application of Shishiwei Jinjin Pills in the Preparation of Drugs for the Treatment of Hypercholesterolemia

[0061] The method of administration is 3 to 4 pills at a time, 0.26 to 0.28 g per pill, twice a day; soak the pills in water at 40°C before taking.

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Abstract

The invention discloses applications of eleven-component golden pills in preparation of a medicine treating hyperlipemia. Animal experiments prove that eleven-component golden pills have substantial treatment effects on experiment mouse hyperlipidemia models, cholesterol, triglyceride and low-density lipoprotein cholesterol levels in blood plasma can be lowered substantially (P is less than 0.01), and lowering effects on part of blood lipid indexes in a high-dosage group is even better than effects of a control medicine. Clinic experiments show that the total clinic effective rate of a treatment group is 91.31%, blood lipid indexes of TC, TG, LDL-C and the like are lowered substantially, HDL-C is raised substantially, and the treatment group is better than the control group in improvement of TC (P is less than 0.05), which show that there is no difference between the eleven-component golden pills and a conventional lipid lowering medicine simvastatin tablets in improvement effects on blood lipid indexes of TG, LDL-C, HDL-C and the like, but the eleven-component golden pills are better than simvastatin tablets in improvement of TC.

Description

technical field [0001] The invention relates to the application of Tibetan medicine Shishiwei Golden Pills in the preparation of medicines for treating hyperlipidemia, which belongs to the field of medicine. Background technique [0002] Dyslipidemia usually refers to elevated plasma cholesterol and (or) triglycerides, or hyperlipidemia, hyperlipidemia. In fact, dyslipidemia also generally refers to various abnormal blood lipids including low high-density lipoprotein cholesterolemia. It is a common disease and frequently-occurring disease. The main cause of disease. According to the report of "Nutrition and Health Status of Chinese Residents (2004)", the prevalence rate of dyslipidemia among adults in my country is 18.6%, and the number of patients is estimated to be 160 million. similar prevalence. Dyslipidemia is a serious threat to the health of our people, therefore, it is very important to do a good job in the early prevention and treatment of dyslipidemia. Tradition...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/738A61P3/06
Inventor 邵成雷赵丽丽付素心魏爱云王朔
Owner SHANDONG JINHE DRUG RES DEV
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