Ent-kaurane diterpenoid compound and preparation method and application thereof

A kaurine type and kaurine technology, which is applied in the field of medicinal chemistry and can solve problems such as less phytochemical research

Inactive Publication Date: 2016-01-06
GUIYANG COLLEGE OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Ent-kaurane diterpenoid compound and preparation method and application thereof
  • Ent-kaurane diterpenoid compound and preparation method and application thereof
  • Ent-kaurane diterpenoid compound and preparation method and application thereof

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Embodiment 1

[0038] Determination of optical rotation Rudolph-type polarimeter (Rudolph Company, USA); hydrogen nuclear magnetic resonance spectrum 1 HNMR, carbon nuclear magnetic resonance spectrum 13 CNMR and 2DNMR were measured by JEOL500MHZ superconducting nuclear magnetic resonance spectrometer (tetramethylsilyl ether TMS as internal standard); high-resolution mass spectrum HR-SIMS was measured by VGAutospec-3000 mass spectrometer (at 70eV); ultraviolet spectrum UV was measured by HP8453 ultraviolet-visible spectrometer Photometer (Hewlett-Packard Company) is measured; Infrared spectrum IR is measured by VECTOR22 type Fourier transform infrared spectrometer (Germany BRUKER Instrument Company, KBr tablet); Melting point is measured by XT-4 binocular micro melting point measuring instrument (Beijing Tektronix Instrument Co., Ltd.) ; Silica gel for column chromatography (200-300 mesh) and silica gel for thin layer chromatography are produced by Qingdao Ocean Chemical; other reagents are ...

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Abstract

The invention discloses ent-kaurane diterpenoid compound and a preparation method and application thereof. The ent-kaurane diterpenoid compound is specifically extracted and separated from Pteris henryi Christ of Pteris of Pteridaceae and named as Pteris henryi Christ butyl-phthalide. Researches prove that the Pteris henryi Christ butyl-phthalide has the obvious anti-virus and HIV-inhibiting activities. The Pteris henryi Christ butyl-phthalide is detected through multiple means such as a superconducting nuclear magnetic resonance spectrum, a high-resolution mass spectrum and a Fourier transform infrared spectrum to determine that the molecular formula is C20H34O3, the molecular weight is 345.2405, and the chemical structural formula is seen in the specification.

Description

technical field [0001] The invention relates to an enantio-kaurane type diterpene compound and its preparation method and application, belonging to the technical field of medicinal chemistry. Background technique [0002] Pterishenryi Chirst is a genus of Pterishenryi Chirst. The plant is a perennial herb with a plant height of 25-40cm. The Pteris genus includes more than 300 species, of which more than 66 species are distributed in China. However, there are only few reports on phytochemical studies of this genus. Our current research on Pteris angustifolia shows that Pteris angustifolia is a perennial herb distributed in limestone areas below 2000m above sea level in Yunnan, Sichuan and Guizhou. The whole herb is used as medicine. Bitter, astringent, cool in nature. Return liver, urinary bladder channel. Heat-clearing and toxic substances removing, astringing sores to stop bleeding, promoting dampness. Indications for burns, rabies bites, traumatic bleeding, profuse ...

Claims

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Application Information

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IPC IPC(8): C07C35/44C07C29/76A61P31/18A61P31/12
CPCC07B2200/07C07B2200/13C07C29/76C07C35/44
Inventor 潘炉台张宏杰张敬杰王娟李宛霏
Owner GUIYANG COLLEGE OF TRADITIONAL CHINESE MEDICINE
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