Fluorescent mesoporous silicon oxide nano particle and preparation method thereof

Abstract

The invention discloses a fluorescent mesoporous silicon oxide nano particle and a preparation method thereof. An improved Stober method is adopted, and the method comprises the steps that surfactants and aqueous alkali are added into secondary water, and stirring is performed at room temperature; the temperature is increased, an inorganic silicon source and an organic fluorescent double-silicon source are added, and after stirring is finished, standing for aging, filtering, washing and drying are performed; the fluorescent mesoporous silicon oxide nano particle is obtained. The fluorescent mesoporous silicon oxide nano particle and the preparation method thereof have the advantages that prepared fluorescent mesoporous silicon oxide nano particle fluorophore is located in an inorganic skeleton, therefore, the effective pore volume of mesoporous channels is greatly increased, and compared with an existing channel-load-modified nano material, the applicability is wider; the prepared fluorescent mesoporous silicon oxide nano particle has the good monodispersity and the neat morphology, and a good carrier is supplied to further application of the material in the biological field.

Description

technical field [0001] The invention belongs to the technical field of advanced nanometer materials, and in particular relates to a fluorescent mesoporous silicon oxide nanoparticle and a preparation method thereof. Background technique [0002] Due to its high specific surface area, unique pore structure, and fluorescence characteristics, fluorescent mesoporous silica materials have good applications in the fields of sensors, drug tracers, and biological imaging. However, at present, the fluorescent functional groups of most fluorescent nanoparticles are introduced into the particle surface or pores by deposition, loading or grafting methods, which will change the surface polarity of nanoparticles or block the pores, resulting in nano The decrease in the utilization rate of particle channels, and easy to cause dye leakage, thus greatly restricting their application development in the biological field, especially in the field of drug carriers. [0003] In order to make fluo...

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Problems solved by technology

However, during the synthesis process, the skeleton of the mesoporous material may collapse and deform, and due to the influence of the hydrolysis rate of the double-headed silicon source, it is difficult to control the morphology and particle size distribution of the prepared nanoparticles, which restricts the further development of such materials. Application and Development

Therefore, how to obtain fluorescent mesoporous silica nanoparticles modified with skeleton organic fluorophores with smooth pore structure, regular shape and controllable particle size is still a huge challenge.

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