A kind of preparation method of inosine and composition injection thereof

A technology of inosine injection and composition, which is applied in the direction of drug combination, medical preparations containing active ingredients, and devices for making drugs into special physical or taking forms, etc., which can solve the safety of patients' medication and the loss of production enterprises , color yellowing and other problems, to achieve the effect of ensuring the quality of medicines

Active Publication Date: 2017-11-03
FUZHOU NEPTUNUS FUYAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Although inosine sodium chloride injection has been listed in the 2010 edition of the "Chinese Pharmacopoeia", it is often found that individual batches of products still have oxidation phenomena such as yellowing and yellowing within the validity period. This uncertain quality problem has not only caused the production Enterprises have caused great losses; and it is very likely to cause drug safety to clinical patients

Method used

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  • A kind of preparation method of inosine and composition injection thereof
  • A kind of preparation method of inosine and composition injection thereof
  • A kind of preparation method of inosine and composition injection thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Accurately weigh the raw and auxiliary materials of each formula in units of 1 million ml of water for injection: inosine 6 kg, sodium chloride 9 kg, glycine 2 kg; medicinal activated carbon 0.1 kg.

[0074] The preparation process comprises the following steps:

[0075] (1) Take 0.1 kg of medicinal activated carbon and make a paste with water for injection.

[0076] (2) Inject 500,000 ml of water for injection into the concentrated preparation tank, add inosine, sodium chloride, and glycine raw materials to stir and dissolve, adjust the pH to 6.5-7.0 with 10% sodium hydroxide solution, and add the adjusted wet medicinal activated carbon Heat to 96°C for 15 minutes.

[0077] (3) After the preparation is completed, the liquid medicine is refluxed and filtered, and the concentrated medicine is filtered using a titanium sintered rod with a pore size not greater than 15 μm for decarburization.

[0078] (4) Use a small beaker to collect the medicinal liquid at the return p...

Embodiment 2

[0087] Accurately weigh the raw and auxiliary materials of each formula in units of 1 million ml of water for injection: inosine 6 kg, sodium chloride 9 kg, glycine 1.5 kg; medicinal activated carbon 0.1 kg.

[0088] The preparation process comprises the following steps:

[0089] (1) Take 0.1 kg of medicinal activated carbon and make a paste with water for injection.

[0090] (2) Inject 500,000 ml of water for injection into the concentrated preparation tank, add inosine, sodium chloride, and glycine raw materials to stir and dissolve, adjust the pH to 6.5-7.0 with 10% sodium hydroxide solution, and add the adjusted wet medicinal activated carbon Heat to 97°C for 15 minutes.

[0091] (3) After the preparation is completed, the liquid medicine is refluxed and filtered, and the concentrated medicine is filtered using a titanium sintered rod with a pore size not greater than 15 μm for decarburization.

[0092] (4) Use a small beaker to collect the medicinal liquid at the return...

Embodiment 3

[0101] Accurately weigh the raw and auxiliary materials of each formula in units of 1 million ml of water for injection: inosine 6 kg, sodium chloride 9 kg, glycine 2.5 kg; medicinal activated carbon 0.1 kg.

[0102] The preparation process comprises the following steps:

[0103] (1) Take 0.1 kg of medicinal activated carbon and make a paste with water for injection.

[0104] (2) Inject 500,000 ml of water for injection into the concentrated preparation tank, add inosine, sodium chloride, and glycine raw materials to stir and dissolve, adjust the pH to 6.5-7.0 with 10% sodium hydroxide solution, and add the adjusted wet medicinal activated carbon Heat to 95°C for 15 minutes.

[0105] (3) After the preparation is completed, the liquid medicine is refluxed and filtered, and the concentrated medicine is filtered using a titanium sintered rod with a pore size not greater than 15 μm for decarburization.

[0106] (4) Use a small beaker to collect the medicinal liquid at the return...

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Abstract

The invention discloses a method for preparing inosine and its composition injection, which is composed of raw material inosine, sodium chloride, glycine as an auxiliary material, and water for injection. 100ml of the composition contains 0.6wt% inosine and 0.9wt% chloride Sodium and 0.15wt%‑0.25wt% glycine; it is a large-volume injection made of inosine and pharmaceutically acceptable auxiliary materials that can be used for injection and has stable quality, and is used for leukopenia and thrombocytopenia caused by various reasons, Adjuvant treatment of heart failure, angina pectoris, hepatitis, etc. It can also be used as an adjuvant treatment for optic atrophy and central retinitis. In addition, it relates to the preparation of a composition injection of polygeline peptide and inosine, which is a large-capacity injection made of polygeline peptide, inosine and pharmaceutically acceptable adjuvants and has stable quality, and is used for acute isovolumetric injections. Blood thinning improves microcirculation and prevents tissue damage from ischemia and hypoxia.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to the preparation of an injection of inosine and its composition. Background technique [0002] inosine. Chemical name: 9-D-ribose hypoxanthine, molecular formula: C 10 H 12 N 4 O 5 , molecular weight: 268.23, chemical structure: [0003] [0004] Inosine is a hypoadenosine compound, a normal component of the human body and a precursor of adenine, which can directly enter the body cells through the cell membrane and participate in nucleic acid metabolism, energy metabolism and protein synthesis in the body. [0005] Inosine can activate the pyruvate oxidase system, increase the activity of coenzyme A, activate liver function, and make tissue cells in a state of low energy and hypoxia continue to metabolize, which is helpful for the recovery of damaged liver cell function. And participate in human energy metabolism and protein synthesis. [0006] Inosine...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/708A61K38/01A61P3/00A61P1/16A61P7/00A61P9/04A61P9/10A61P25/02A61P27/02A61J3/00A61K47/18
Inventor 俞宁
Owner FUZHOU NEPTUNUS FUYAO PHARMA
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