High-stability antibacterial agent containing cinnamon essential oil nanoliposomes and method for preparing high-stability antibacterial agent containing cinnamon essential oil nanoliposomes

A technology of nano-liposome and cinnamon essential oil, which is applied in the field of antibacterial agents, pharmaceutical preparations or cosmetics, and can solve the problems of high production cost and low output rate of cinnamon oil

Inactive Publication Date: 2016-02-03
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There are many patent applications about the extraction and health care application of cinnamon at home and abroad; CN102952629A discloses a new method that can solve the problems of low cinnamon oil output rate and high production cost when distilling and extracting natural cinnamon oil; US2012128803A1 discloses a A new method that can reduce toxic cinnamaldehyde and coumarin in cinnamon extract; CN104117013A discloses a cinnamon powder formula for treating gastritis; A preparation

Method used

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  • High-stability antibacterial agent containing cinnamon essential oil nanoliposomes and method for preparing high-stability antibacterial agent containing cinnamon essential oil nanoliposomes
  • High-stability antibacterial agent containing cinnamon essential oil nanoliposomes and method for preparing high-stability antibacterial agent containing cinnamon essential oil nanoliposomes
  • High-stability antibacterial agent containing cinnamon essential oil nanoliposomes and method for preparing high-stability antibacterial agent containing cinnamon essential oil nanoliposomes

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The encapsulation efficiency of embodiment 1 multilayer cinnamon essential oil nano liposome

[0034] 1 Experimental materials

[0035] Soybean lecithin; BR; Sinopharm Chemical Reagent Co., Ltd.

[0036] Cholesterol; AR; Sinopharm Chemical Reagent Co., Ltd.

[0037] Chloroform; AR; Sinopharm Chemical Reagent Co., Ltd.

[0038] Cinnamon essential oil; AR; French florihana essential oil.

[0039] PVP; GR; Sinopharm Chemical Reagent Co., Ltd.

[0040] Chitosan; BR; Sinopharm Chemical Reagent Co., Ltd.

[0041] Gelatin; BR; Sinopharm Chemical Reagent Co., Ltd.

[0042] 2 Experimental methods

[0043] 1) Preparation of monolayer cinnamon essential oil nanoliposomes

[0044] ① Weigh 1g of soybean lecithin, 0.2g of cholesterol and 150mg of cinnamon essential oil, add 50mL of chloroform to dissolve it.

[0045] ② Evaporate in a rotary evaporator until the solvent is evaporated to dryness. The evaporation temperature is 10~30°C. A smooth film will be formed on the inne...

Embodiment 2

[0066] Particle diameter and polydispersity index PDI of embodiment 2 multilayer cinnamon essential oil nano liposomes

[0067] 1 Experimental materials

[0068] ① Single-layer cinnamon essential oil nanoliposomes.

[0069] ② Double layer cinnamon essential oil nano liposomes.

[0070] ③ Multilayer cinnamon essential oil nano liposomes.

[0071] 2 Experimental methods

[0072] The particle size and the polydispersity index PDI value of the cinnamon essential oil nanoliposomes were measured with a high-concentration laser particle size analyzer model BI-9000 produced by Brookhaven Instruments in the United States, and the measured samples were put into the sample cell for direct measurement.

[0073] 3 Particle size and polydispersity index PDI of cinnamon essential oil nanoliposomes

[0074] The polydispersity index PDI directly reflects the stability of cinnamon essential oil nano-liposomes, so it is the main reference index. The PDI of liposomes is the best in the rang...

Embodiment 3

[0075] The Zeta potential of embodiment 3 cinnamon essential oil nano liposomes

[0076] 1 Experimental materials

[0077] ① Single-layer cinnamon essential oil nanoliposomes.

[0078] ② Double layer cinnamon essential oil nano liposomes.

[0079] ③ Multilayer cinnamon essential oil nano liposomes.

[0080] 2 Experimental methods

[0081] The model ZetasirernanoZS-Zeta potentiometer produced by British Malvern Instrument Co., Ltd. is used for measurement, and the liposome sample to be tested is directly put into the potentiometer for measurement.

[0082] 3 Zeta potential of cinnamon essential oil nanoliposomes

[0083] Table 1 Zeta potential of cinnamon essential oil nanoliposomes

[0084]

[0085] Zeta potential can also directly reflect the stability of cinnamon essential oil nano-liposomes, so it is also the main reference index. The larger the absolute value of the Zeta potential of liposomes, the more stable the liposomes. The absolute value of Zeta potential i...

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Abstract

The invention belongs to the field of antibacterial agents and pharmaceutical preparations or cosmetics and particularly relates to a high-stability antibacterial agent containing cinnamon essential oil nanoliposomes and a method for preparing the high-stability antibacterial agent containing the cinnamon essential oil nanoliposomes. The cinnamon essential oil nanoliposomes are prepared from cinnamon essential oil, soybean lecithin, cholesterol, surfactant, chitosan and gelatin. The method includes: mixing the cinnamon essential oil, the soybean lecithin and the cholesterol into an organic solvent, decompressing and evaporating for drying to form a smooth membrane, adding an aqueous-phase medium and the surfactant to dissolve the membrane, emulsifying ultrasonically, mixing with the chitosan and gelatin solution homogenously and uniformly, and performing centrifugation and micropore membrane filtration to obtain the nanoliposomes. A preparation process is high in reproducibility, encapsulation rate of multilayer cinnamon essential oil nanoliposomes can reach 90.4% maximally, and product integrity, uniform particle size and high stability and antibacterial performance are realized.

Description

technical field [0001] The invention belongs to the field of antibacterial agents and pharmaceutical preparations or cosmetics, and in particular relates to the preparation of a highly stable cinnamon essential oil nano liposome antibacterial agent and a preparation method thereof. Background technique [0002] Cinnamon is a lauraceae plant, distributed in Fujian, Guangdong, Guangxi, Yunnan and other places. Cinnamon essential oil is a volatile oil extracted from the dried bark of cinnamon, which has a strong aroma and acrid smell; cinnamon oil is widely used as a natural edible spice in food Applications, involving almost all aspects, are mainly used in soft drinks, candy, canned food, baked goods, alcohol and tobacco, etc.; cinnamon essential oil is a mixture of various organic substances, and its main components are: alkenes, aromatic derivatives Due to its special chemical composition, cinnamon essential oil has shown good antibacterial activity in many studies, and has ...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K36/54A61P31/04A01N65/24A01N25/28A01P1/00
Inventor 崔海英周慧林琳
Owner JIANGSU UNIV
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