High-stability antibacterial agent containing cinnamon essential oil nanoliposomes and method for preparing high-stability antibacterial agent containing cinnamon essential oil nanoliposomes

Abstract

The invention belongs to the field of antibacterial agents and pharmaceutical preparations or cosmetics and particularly relates to a high-stability antibacterial agent containing cinnamon essential oil nanoliposomes and a method for preparing the high-stability antibacterial agent containing the cinnamon essential oil nanoliposomes. The cinnamon essential oil nanoliposomes are prepared from cinnamon essential oil, soybean lecithin, cholesterol, surfactant, chitosan and gelatin. The method includes: mixing the cinnamon essential oil, the soybean lecithin and the cholesterol into an organic solvent, decompressing and evaporating for drying to form a smooth membrane, adding an aqueous-phase medium and the surfactant to dissolve the membrane, emulsifying ultrasonically, mixing with the chitosan and gelatin solution homogenously and uniformly, and performing centrifugation and micropore membrane filtration to obtain the nanoliposomes. A preparation process is high in reproducibility, encapsulation rate of multilayer cinnamon essential oil nanoliposomes can reach 90.4% maximally, and product integrity, uniform particle size and high stability and antibacterial performance are realized.

Description

technical field [0001] The invention belongs to the field of antibacterial agents and pharmaceutical preparations or cosmetics, and in particular relates to the preparation of a highly stable cinnamon essential oil nano liposome antibacterial agent and a preparation method thereof. Background technique [0002] Cinnamon is a lauraceae plant, distributed in Fujian, Guangdong, Guangxi, Yunnan and other places. Cinnamon essential oil is a volatile oil extracted from the dried bark of cinnamon, which has a strong aroma and acrid smell; cinnamon oil is widely used as a natural edible spice in food Applications, involving almost all aspects, are mainly used in soft drinks, candy, canned food, baked goods, alcohol and tobacco, etc.; cinnamon essential oil is a mixture of various organic substances, and its main components are: alkenes, aromatic derivatives Due to its special chemical composition, cinnamon essential oil has shown good antibacterial activity in many studies, and has ...

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Problems solved by technology

[0003] There are many patent applications about the extraction and health care application of cinnamon at home and abroad; CN102952629A discloses a new method that can solve the problems of low cinnamon oil output rate and high production cost when distilling and extracting natural cinnamon oil; US2012128803A1 discloses a A new method that can reduce toxic cinnamaldehyde and coumarin in cinnamon extract; CN104117013A discloses a cinnamon powder formula for treating gastritis; A preparation method of a preservative containing cinnamon extract; Mexican patent MX2013014822A discloses a pesticide composition containing cinnamon that can kill crawling insects; Korean patent KR20130112571A discloses a combination of cinnamon that can be used as an insecticide CN103653179B discloses a method for preparing liposomes with soybean lecithin, cholesterol, vitamin E and Tween-80; CN103271996A discloses a preparation method of cinnamon essential oil and mixed cyclodextrin inclusion compound

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