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Anti-radiation anti-caries inflammation-diminishing oral preparation

An anti-radiation and oral technology, applied in pill delivery, digestive system, antibacterial drugs, etc., can solve the problems of not suitable for emergency protection, preventive treatment, lack of pertinence and portability, poor curative effect, etc., to meet the requirements of prevention and treatment Guaranteeing work needs, eliminating dentin hypersensitivity, and rapidly dissolving effects

Inactive Publication Date: 2016-02-17
中国人民解放军96617部队
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the drugs for radiation-induced oral diseases are generally symptomatic treatment, with poor curative effect, certain toxic and side effects, lack of pertinence and portability, and are not suitable for preventive treatment under emergency support and field training conditions

Method used

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  • Anti-radiation anti-caries inflammation-diminishing oral preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: Composition, preparation, and use of anti-radiation anti-caries anti-inflammatory mouthwash

[0029] Mouthwash dosage form anti-radiation caries anti-inflammation oral preparation, which comprises, by mass fraction, 0.5% oltipraz, 0.3% recombinant human keratinocyte growth factor, 0.02% domiphene, 0.02% thymol, 0.02% tinidazole, 0.1% molasses, 0.05% menthol, 0.01% peppermint oil, 2% glycerin, 4% ethanol, and the balance is distilled water.

[0030] Preparation method: in a sterile production workshop, add oltipraz, recombinant human keratinocyte growth factor, domiphene, thymol, and tinidazole into a clean glass container in sequence according to the above mass fractions, and stir gently. After fully mixing evenly, add the above-mentioned mass fraction of menthol, peppermint oil, sweetener, glycerin, ethanol, and distilled water to make a uniform mixture. After fully mixing all the mixtures, fill them in sterile plastic bottles and seal them into library, st...

Embodiment 2

[0033] Example 2: Composition, preparation, and use of anti-radiation anti-caries anti-inflammatory oral concentrated spray liquid

[0034] Concentrated spray type anti-radiation, anti-caries and anti-inflammatory oral preparation, which includes, by mass fraction, 1.2% oltipraz, 0.8% recombinant human keratinocyte growth factor, 0.04% domiphene, and 0.03% thymol , 0.04% tinidazole, 0.1% molasses, 0.05% menthol, 0.01% peppermint oil, 2% glycerin, 4% ethanol, and the balance is distilled water.

[0035] Preparation method: In the aseptic production workshop, add oltipraz, recombinant human keratinocyte growth factor, domiphene, thymol, and tinidazole into a clean glass container in sequence according to the above mass fractions, and stir gently , after fully mixing evenly, then add the above-mentioned mass fraction of menthol, peppermint oil, sweetener, glycerin, ethanol, distilled water uniform mixture, after all the mixture is fully mixed, input into the storage tank, store f...

Embodiment 3

[0038] Example 3: Composition, preparation, and use of anti-radiation anti-caries anti-inflammatory Subengxixiao tablets

[0039] Subeng Xixiao tablet type anti-radiation, anti-caries and anti-inflammatory oral preparation, which includes, by mass fraction, 5% oltipraz, 2% recombinant human keratinocyte growth factor, 0.2% domiphene, 0.2% Thymol, 0.5% Tinidazole, 5% Soluble Starch, 56.1% Mannitol, 9% Povidone K30, 15% Microcrystalline Cellulose, 5% Crospovidone XL- 10, 2% Menthol.

[0040] Preparation method: Weigh oltipraz, recombinant human keratinocyte growth factor, domiphene, thymol, tinidazole, and mannitol respectively according to the stated mass fractions, add them into a clean glass container, stir gently, and mix thoroughly After uniformity, add 5% of soluble starch to form the active ingredient unit of the fast-collapsing mouthwash tablet, then add 9% of povidone K30 solution, stir, pass through a 40-mesh sieve to granulate, dry, and put 15% into micro Crystalliz...

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Abstract

The invention belongs to technical field of oral pharmaceutical preparations and particularly relates to a multifunctional anti-radiation anti-caries inflammation-diminishing oral pharmaceutical preparation. According to the technical scheme, the anti-radiation anti-caries inflammation-diminishing oral preparation is prepared from, by mass, 0.5%-5% of oltipraz, 0.3%-2% of a recombinant human horny cell growth factor, 0.02%-0.2% of domiphen, 0.02%-0.2% of thymol, 0.02%-0.5% of tinidazole and the balance auxiliary medicines, a freshener, a sweetener, a plasticizer, a disintegrating agent, an algefacient, a stabilizing agent and the like. The anti-radiation anti-caries inflammation-diminishing oral preparation can be made into mouthwash, can be concentrated into spray liquid or can be quickly disintegrated into washing and disinfecting tablets. The anti-radiation anti-caries inflammation-diminishing oral preparation is researched and developed based on pathogenic factors of ionized radiative oral diseases and meets the multi-aspect demands of convenient carrying, prevention and guarantee at ordinary times, emergent treatment and curing in wartime and the like.

Description

technical field [0001] The invention belongs to the technical field of oral pharmaceutical preparations, in particular to a multifunctional anti-radiation, anti-caries and anti-inflammation oral pharmaceutical preparation. Background technique [0002] After the human body is exposed to a certain dose of ionizing radiation, not only the early acute effects can appear at the time of exposure, but also the long-term effects appear after several years or even longer after exposure. The effect of ionizing radiation on water molecules and biomolecules such as proteins in human cells is of special significance. The ionization and excitation of water molecules produce free radicals, and free radicals are the main cause of radiation damage to organic molecules; In addition ionizing radiation can cause cell division delay (divisiondelay) changes and cell death. Biological effects produced by radiation include direct action and indirect action. Direct action is the effect caused by ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/18A61K9/20A61K9/12A61K9/08A61P1/02A61P31/04A61K31/05A61K31/14A61K31/4164A61K31/497
Inventor 李广文李卉张陈兵曹思樟王军
Owner 中国人民解放军96617部队
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