A drug-loaded hydrogel coating and its preparation method and application
A kind of alumina hydrogel, gel technology, applied in coating, medical science, medical container and other directions, can solve problems such as vascular restenosis, achieve long-lasting anti-thrombotic effect and prevent protein deposition.
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Embodiment 1
[0042] In this embodiment, the drug-loaded hydrogel coating is prepared by the following method, which specifically includes the following steps:
[0043] (1) Add 2.5g of aluminum isopropoxide into 50mL of deionized water, stir the white precipitate at 80°C for 15min to obtain a dispersion, ultrasonically treat the dispersion for 2h, and cool to room temperature to obtain an alumina hydrogel (Al 2 o 3 ·H 2 O), wherein the mass content of aluminum is 2%.
[0044] (2) Dissolve 10 mg of the antithrombotic drug enoxaparin sodium in 1 mL of Tris-hydrochloric acid buffer (concentration 0.05M) at pH=7.4 to obtain an antithrombotic drug solution, and mix 100 μL of the alumina hydrogel obtained in step (1) with 50 μL of antithrombotic drug solution was mixed evenly in a 1.5mL glass tube, and then 50 μL of the mixed solution was taken on a glass slide (2cm×2cm in size) with a pipette gun, and the Meyer rod was used to repeatedly press and coat 5 times to coat evenly, and then put Dry...
Embodiment 2
[0046] In this embodiment, the drug-loaded hydrogel coating is prepared by the following method, which specifically includes the following steps:
[0047] (1) Add 2.5g of aluminum isopropoxide into 25mL of deionized water, stir the white precipitate at 80°C for 30min to obtain a dispersion, ultrasonically treat the dispersion for 1h, and cool to room temperature to obtain an alumina hydrogel (Al 2 o 3 ·H 2 O), wherein the mass content of aluminum is 3%.
[0048] (2) 10 mg of antithrombotic drug ticlopidine was dissolved in 2 mL of Tris-hydrochloric acid buffer (concentration 0.05 M) at pH=7.4 to obtain an antithrombotic drug solution, and 100 μL of the alumina hydrogel obtained in step (1) was mixed with 80 μL of antithrombotic drug solution was mixed evenly in a 1.5mL glass tube, and then 50 μL of the mixed solution was taken on a glass slide (2cm×2cm in size) with a pipette gun, and the Meyer rod was used to repeatedly press-coat 7 times to coat evenly, and then put Dry i...
Embodiment 3
[0050] In this embodiment, the drug-loaded hydrogel coating is prepared by the following method, which specifically includes the following steps:
[0051] (1) Add 2.5g of aluminum isopropoxide into 75mL of deionized water, stir the white precipitate at 80°C for 20min to obtain a dispersion, ultrasonicate the dispersion for 3h, cool to room temperature, and obtain an alumina hydrogel (Al 2 o 3 ·H 2 O), wherein the mass content of aluminum is 1%.
[0052] (2) Dissolve 10 mg of the antithrombotic drug urokinase in 3 mL of Tris-hydrochloric acid buffer (concentration 0.05 M) at pH=7.4 to obtain an antithrombotic drug solution, mix 100 μL of the alumina hydrogel obtained in step (1) with 30 μL of antithrombotic Mix the thrombus drug solution evenly in a 1.5mL glass tube, then use a pipette gun to take 50μL of the mixed solution on a glass slide (2cm×2cm in size), use a Meyer rod to repeatedly press and coat 3 times to coat evenly, and then put it in a vacuum Dry in a drying oven...
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Abstract
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