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Preparation method for titanium-doped hydroxyapatite/zirconia composite ceramic material

A technology of hydroxyapatite and composite ceramics, which is applied in the field of bone tissue engineering, and can solve problems such as high thermal expansion coefficient, high thermal expansion coefficient of calcium oxide, and large thermal expansion rate.

Inactive Publication Date: 2016-03-02
丁玉琴
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem mainly solved by the present invention: aiming at the current single-component hydroxyapatite as bone tissue engineering material with low strength and poor toughness, zirconia has excellent room temperature mechanical properties, high strength, high fracture toughness, corrosion resistance and biological inertness. Hydroxyapatite is the first choice material for toughening, but the thermal expansion rate of zirconia products at high temperature is high, and the thermal expansion coefficient is high, resulting in poor thermal shock resistance and being crushed or peeled off, while zirconia is difficult to sinter at low temperature The problem is to provide a preparation method of titanium-doped hydroxyapatite / zirconia composite ceramic material. The method first prepares titanium-doped hydroxyapatite, then mixes it with zirconia powder, and releases a large amount of Heat to sinter the composite material, and materials such as magnesium oxide, magnesium nitride and calcium oxide powder that are simultaneously generated in a high temperature environment are used as a stabilizer to solve the problem of high thermal expansion coefficient when calcium oxide is used alone. The composite ceramics prepared by the present invention The material combines the biological activity of hydroxyapatite material with the high strength and good toughness of zirconia, and is a good substitute material for bone tissue engineering

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0017] Weigh 1kg of hydroxyapatite, put it into a stone crusher and crush it through a 40-mesh standard sieve, transfer the crushed particles into a mortar, grind them into powder, and take 100g of hydroxyapatite powder and pour it into a 1L beaker, add 700mL of distilled water was placed on a magnetic stirrer, and stirred at a speed of 300r / min for 20min to obtain a hydroxyapatite suspension; 0.5g of tetrabutyl titanate was added to 10mL of absolute ethanol, stirred evenly with a glass rod, and The prepared tetrabutyl titanate ethanol solution is dropped into the hydroxyapatite suspension in a stirring state, and the dropping speed is controlled so that the dropping is completed within 10 minutes. After the dropping is completed, the shaking table is oscillated for 5 hours and sealed and left standing 24h; Take the above-mentioned mixed solution after standing still and pour it into a Buchner funnel, wash and filter with absolute ethanol and deionized water for 3 times respect...

example 2

[0020]Weigh 1 kg of hydroxyapatite, put it into a stone crusher and crush it through a 40-mesh standard sieve, move the crushed particles into a mortar, grind them into powder, and pour 150 g of hydroxyapatite powder into a 1L beaker, add 750mL of distilled water was placed on a magnetic stirrer, and stirred at a speed of 350r / min for 25min to obtain a hydroxyapatite suspension; 0.8g of tetrabutyl titanate was added to 15mL of absolute ethanol, stirred evenly with a glass rod, and The prepared tetrabutyl titanate ethanol solution is dropped into the hydroxyapatite suspension in a stirring state, and the dropping speed is controlled so that the dropping is completed within 15 minutes. After the dropping is completed, the shaking table is oscillated for 5 hours and sealed and left standing 30h; take the above-mentioned mixed solution after standing still and pour it into a Buchner funnel, wash and filter with absolute ethanol and deionized water for 4 times respectively, separate...

example 3

[0023] Weigh 2kg of hydroxyapatite, put it into a stone crusher and crush it through a 40-mesh standard sieve, move the crushed particles into a mortar, grind them into powder, and take 200g of hydroxyapatite powder and pour it into a 1L beaker, add 800mL of distilled water was placed on a magnetic stirrer, and stirred at a speed of 400r / min for 30min to obtain a suspension of hydroxyapatite; 1g of tetrabutyl titanate was added to 20mL of absolute ethanol, stirred evenly with a glass rod, and the prepared The obtained tetrabutyl titanate ethanol solution was dropped into the hydroxyapatite suspension in a stirring state, and the dropping speed was controlled so that the dropping was completed within 20 minutes. After the dropping was completed, the shaking table was oscillated for 6 hours and left to stand in an airtight place for 36 hours. ; Take the above-mentioned static mixture and pour it into a Buchner funnel, wash and filter it with absolute ethanol and deionized water f...

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Abstract

The present invention relates to a preparation method for a titanium-doped hydroxyapatite / zirconia composite ceramic material and belongs to the field of bone tissue engineering. The method comprises the steps of preparing titanium-doped hydroxyapatite; mixing the titanium-doped hydroxyapatite with zirconia powder; and sintering the composite material by using a large amount of heat released by a thermite reaction. Moreover, magnesium oxide, magnesium nitride, and the like simultaneously generated in the high-temperature environment with calcium oxide powder are taken together as a stabilizer to solve the problem of a high thermal expansion coefficient caused by independently using calcium oxide as the stabilizer. The prepared composite ceramic material disclosed by the present invention combines bioactivity of the hydroxyapatite material, and high strength and good toughness of the zirconia, and thus is a good alternative material for the bone tissue engineering.

Description

technical field [0001] The invention relates to a preparation method of a titanium-doped hydroxyapatite / zirconia composite ceramic material, belonging to the field of bone tissue engineering. Background technique [0002] As a bioceramic material, hydroxyapatite plays a very important role in bone and tooth defect repair and bone tissue engineering replacement. From the perspective of composition, the inorganic component of human bone is bone apatite. Usually, bone apatite contains many other ions, such as K + 、Na + , Mg + 、CI 一 , F 一 and CO 3 2一 etc., these ions will replace Ca in apatite to varying degrees 2+ or OH - , plays a very important role in biological processes in the human body. From the structural point of view, the structure of human bone apatite is about 40-60nm long and about 20nm wide. The main basic unit is needle-like or rod-like apatite crystals. For the delivery of substances, the interconnected three-dimensional porous structure can allow cell...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/48
Inventor 丁玉琴林大伟
Owner 丁玉琴