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Kefir fermentation scrophularia henryi hemsl powder and preparation method thereof

A technology of ginseng powder and kefir grains, which is applied in powder delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as complex operation and technical conditions, low concentration of reaction substrates, and low output, and achieve High content, easy handling, energy saving effect

Inactive Publication Date: 2016-03-23
许勇男
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the reaction substrate concentration is low, the yield is low, and the operation and technical conditions are complicated

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Preparation method of kefir fermented black ginseng powder:

[0032]1. Preparation of ginsenoside compound enzyme fermentation broth: use skimmed milk powder, wort with a Baumé degree of 12 ° Be', water as a medium, and ginseng powder or ginseng extract as an enzyme inducer. Gradually transfer kefir grains to skimmed milk powder: wort: water respectively 1:8:1, 1:7:2, 1:6:3, 1:5:4, 1:4:5, 1: Add 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 3.0% of ginseng powder or ginseng extract to different culture media in 5:6 order, culture at 25°C-38°C for 24-48h, and gradually increase Cultivation temperature, finally inoculated in a medium with a wort:water ratio of 1:1, added 5.0% ginseng powder or ginseng extract, cultivated at 35°C-38°C for 48-120h, separated the fermentation broth, and obtained ginsenoside complex enzyme fermentation broth.

[0033] 2. Use 0.2% to 0.5% sodium chloride aqueous solution as an enzyme activator, spray it on the surface of ginseng, and grind it into coarse po...

Embodiment 2

[0043] Preparation method of kefir fermented black ginseng powder:

[0044] 1. Preparation of ginsenoside compound enzyme fermentation broth: use skimmed milk powder, wort with a Baumé degree of 12 ° Be', water as a medium, and ginseng powder or ginseng extract as an enzyme inducer. Gradually transfer kefir grains to skimmed milk powder: wort: water respectively 1:8:1, 1:7:2, 1:6:3, 1:5:4, 1:4:5, 1: Add 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 3.0% ginseng powder or ginseng extract in sequence to different media at 5:6, culture at 30°C for 48 hours, increase the culture temperature step by step, and finally inoculate Add 5.0% ginseng powder or ginseng extract to a medium with wort:water ratio of 1:1, preferably culture at 38° C. for 120 h, separate the fermentation broth, and obtain a ginsenoside complex enzyme fermentation broth.

[0045] 2. Preferably 0.3% sodium chloride aqueous solution is used as an enzyme activator, sprayed on the surface of ginseng, dried and crushed into coarse ...

Embodiment 3

[0051] The influence of embodiment 3 fermented liquid culture condition on fermented product

[0052] 1. Effect of fermentation conditions on induction of ginsenoside compound enzyme

[0053] Fermentation conditions such as microbial strains, medium concentration, fermentation temperature, and fermentation time have a greater impact on the types of induced ginsenoside complex enzymes. Specific ginsenoside glucosidase fermentation conditions require lower content of carbon and nitrogen sources, low-concentration medium, high temperature culture, and prolonged culture time. The hydrolyzate of ginsenoside compound enzyme fermentation broth contains more ginsenoside C-K.

[0054] When the culture temperature is 25°C, the hydrolyzed ginsenoside Rb is mainly produced 1 Converted to Rd, Rg 3 Enzymes that can also hydrolyze Re, Rg 1 The 20-O-glycosyl, generate Rg respectively 2 and Rh 1 ; When the culture temperature is 35°C, it mainly produces hydrolyzed ginsenoside Rb 1 , Rb...

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Abstract

The invention discloses Kefir fermentation scrophularia henryi hemsl powder and a preparation method thereof. Kefir grains serve as a strain and undergo strain domestication and enzyme production induction to obtain ginsenoside compound enzyme fermentation liquid. Ginseng undergoes processes including solid fermentation, inactivation, vacuum drying and superfine grinding and the like to obtain the Kefir fermentation scrophularia henryi hemsl powder. The Kefir fermentation scrophularia henryi hemsl powder manufactured according to the method contains rare ginsenosides C-K Rhi and Rh2 which can be directly absorbed and utilized by the human body to have a therapeutic effect. The method has the advantages that the reaction conditions are mild, a high-concentration product can be produced through a high substrate concentration, energy is saved, no strict aseptic condition is required, and the method is free of pollution.

Description

technical field [0001] The invention relates to kefir fermented black ginseng powder and a preparation method thereof, belonging to the technical field of medicine and health products. Background technique [0002] Ginsenosides are not directly absorbed by the human body in a natural form, nor are they decomposed by gastric juice and liver enzymes, so the degree of direct absorption and utilization by the human body is extremely low. The real therapeutic effect of ginseng is the secondary metabolites of ginsenosides metabolized by intestinal microorganisms, namely ginsenosides C-K, Rh 1 、Rh 2 , Rg 1 , Rg 3 and other rare ginsenosides. Rare ginsenosides have strong physiological activity, such as ginsenosides C-K, Rh 1 、Rh 2 etc., have extremely strong anticancer activity and medical and health care value. [0003] The types of bacteria in the human intestinal tract and individual metabolism vary greatly. Daily diet, health status, mental stress, etc. will affect the m...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61K9/14A61P17/18A61P35/00A61P29/00A61P9/00A61P1/16A61P37/08A61P25/00A61P37/02
CPCA61K36/258A61K9/14A61K2236/19
Inventor 李锡涛许勇男郭敏
Owner 许勇男
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